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Being physically active, even just a couple of days a week, may be key to better health

Being physically active for one to two days a week, often called a “weekend warrior,” may provide comparable health and life-prolonging benefits as smaller doses of daily physical activity if the physical effort is moderate to vigorous and totals 150 minutes a week in line with recommended guidelines for weekly physical activity.

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Being physically active for one to two days a week, often called a “weekend warrior,” may provide comparable health and life-prolonging benefits as smaller doses of daily physical activity if the physical effort is moderate to vigorous and totals 150 minutes a week in line with recommended guidelines for weekly physical activity.

This is according to new research published in the Journal of the American Heart Association, an open access, peer-reviewed journal of the American Heart Association.

“You don’t need to exercise every day to stay healthy. As long as you get 150 minutes of moderate to vigorous physical activity per week — whether packed into one to two days or spread out — you can significantly reduce your risk of dying from cardiovascular disease, cancer or other causes,” said study corresponding author Zhi-Hao Li, Ph.D., an epidemiologist in the School of Public Health at Southern Medical University in Guangzhou, China.

“This message is encouraging news for busy people who struggle to fit in daily workouts but can manage a concentrated burst of activity on weekends or over a couple of days,” Li said. “The research provides reassuring evidence that even sporadic physical activity can have lasting health benefits, making it easier for people to prioritize their well-being amid busy schedules.”

To achieve health benefits, both the World Health Organization and the American Heart Association recommend that throughout a week adults engage in 150 to 300 minutes of moderate-intensity aerobic physical activity, or 75 to 150 minutes of vigorous-intensity aerobic physical activity, or an equivalent combination of moderate and vigorous-intensity activity.

Researchers examined health and physical activity data for more than 93,000 people in a large biomedical database in the U.K. to explore how different physical activity patterns may affect the risk of dying from all causes, specifically cardiovascular disease and cancer. They reviewed physical activity data collected from wrist accelerometers, devices that measure movement and are likely more accurate than asking participants about their activity.

The study categorized the data into three groups: “active weekend warrior” — people who completed most of their exercise in one or two days; “active regular” — those who spread their activity throughout the week; and “inactive” — participants who did not complete the recommended minimum of 150 minutes of weekly physical activity.

Compared to the inactive group, the weekend warrior and active regular groups had a significantly lower risk of death from all causes, cardiovascular disease and cancer if they completed 150 minutes of physical activity a week.

The analysis also found:

  • For weekend warriors, the risk of death from all causes was 32% lower; the risk of death from cardiovascular disease was 31% lower; and the risk of death from cancer was 21% lower.
  • Among participants in the active regular group, the risk of death from all causes was 26% lower; the risk of death from cardiovascular disease was 24% lower; and the risk of death from cancer was 13% lower.
  • No significant differences in the risk of death surfaced between the weekend warrior vs. the active regular group.

While the new research aligns with previous studies, it is the first to analyze the relationship between physical activity patterns measured by accelerometers and the risk of death from cardiovascular disease and cancer.

Some of the findings surprised the research team, who initially expected that spreading activity throughout the week would be more beneficial. They did not anticipate that weekend warriors’ condensed physical activity would reduce the risk of death from disease.

“This reinforces the idea that meeting the 150-minutes of physical activity per week guideline is key to longevity, regardless of the activity pattern,” Li said. “Any activity — whether structured exercise such as jogging or daily tasks such as gardening — can be included if the intensity is moderate to vigorous.”

American Heart Association expert volunteer Keith Diaz, Ph.D., said the findings emphasize that the total volume of physical activity is the crucial factor for health benefits, rather than how it is distributed across a week. Diaz, the Florence Irving Associate Professor of Behavioral Medicine at Columbia University Medical Center in New York, was not involved in this research.

“Many people struggle to fit in daily exercise during the workweek; however, this research shows that even if you can only be active on the weekends, you can still gain meaningful health benefits,” said Diaz, a member of the Association’s Physical Activity Science Committee.

“One important caveat to remember is that trying to fit 150 minutes of exercise into just one or two days can be a lot on your body,” he added. “Some research suggests that weekend warriors have a slightly higher risk of musculoskeletal injuries compared to those who exercise more regularly. However, the benefits of exercising just on the weekend far outweigh the potential risks. If you are going to be a weekend warrior, make sure you do proper warm-ups and build up and progress to higher volumes of activity over time. This will help to reduce your risk of injuries.”

The study had several limitations, including that physical activity was only measured at baseline; participants lived in the U.K. and most were white, so the results may not apply to other populations. The researchers said future studies should be conducted to confirm these results in more diverse groups of people throughout the world and with more consideration for contradictory factors such as genetic predisposition or environmental exposures that may influence physical activity and the outcomes.

Study details, background and design:

  • The research data focused on seven days of accelerometer-measured physical activity from 2013 to 2015 for 93,409 participants, aged 37 to 73, enrolled in the UK Biobank.
  • More than 56% of the participants were women, 97% were white and their average age was 62 years old.
  • Based on accelerometer data, more than 42% of participants were classified as weekend warrior, about 24% as active regular and nearly 34% as inactive.
  • The accelerometers captured a range of activities, including walking, jogging, stationary cycling, elliptical exercises, household chores, gardening and leisure activities such as dancing.
  • During eight years of follow-up, nearly 4,000 adults died from all causes, including about 17% from cardiovascular disease and about 45% from cancer.
  • Compared to the inactive participants, those who exercised during two days each week were more likely to be men, younger, have a college degree, non-smokers, non-drinkers, less likely to have Type 2 diabetes and/or to have lower body mass index (an indicator of body fat to determine healthy weight).

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Wellness

Men’s health expert issues warning to fans copying Mark Wahlberg’s early starts

Getting up at 3 a.m. might look like a head start in a social media morning routine. But for men tempted to copy it, there is an important question to answer before setting the alarm: what time will you actually be asleep?

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A men’s health expert explains why copying an early alarm without changing your bedtime could leave you tired, unfocused and less productive

Getting up at 3 a.m. might look like a head start in a social media morning routine. But for men tempted to copy it, there is an important question to answer before setting the alarm: what time will you actually be asleep?

Anneliese Cadena, a board-certified nurse practitioner and clinical consultant at Feel30, is encouraging men to protect their sleep when adopting an earlier routine. Moving the alarm forward without bringing bedtime forward can reduce the rest needed to function well during the day.

“If you normally wake up at 7 a.m., suddenly setting your alarm for 3 a.m. while keeping the same bedtime cuts four hours from your opportunity to sleep. That can leave you feeling worse during the day, even if you manage to get out of bed.”

The consequences can undermine the very reason for getting up early. According to the National Heart, Lung, and Blood Institute, insufficient sleep can affect concentration, decision-making and reaction times, leaving people taking longer to finish tasks and making more mistakes.

For someone who needs eight hours of sleep, a 3 a.m. alarm means being asleep by 7 p.m. the previous evening. That also requires time beforehand to wind down and fall asleep.

Start with a smaller change

For men who want an earlier start, a more manageable approach is to adjust the evening routine gradually.

Cleveland Clinic recommends moving bedtime earlier by 15 or 20 minutes for a few days, then making another small adjustment. Its guidance advises seven to nine hours of sleep each night.

Someone who usually wakes at 7 a.m. could start by working toward 6:45 a.m., alongside an earlier bedtime. Further changes should leave enough time for sleep. Moving the alarm forward by a full hour every day can quickly eat into rest if bedtime does not keep pace.

If falling asleep earlier proves difficult, or daytime sleepiness increases, pause further changes and reconsider whether the target wake-up time fits your needs.

Anneliese adds: 

“Choose a wake-up time that fits your responsibilities and still gives you enough sleep. Getting up at 6 a.m. and feeling rested may serve you much better than forcing a 3 a.m. start that leaves you struggling through the afternoon.”

An earlier morning starts the evening before

Changing the alarm may also mean reconsidering an afternoon coffee or a late evening spent scrolling.

The NHLBI recommends keeping a consistent sleep schedule and using the hour before bed for quiet time, while avoiding bright artificial light. It also notes that caffeine’s effects can last up to eight hours, which matters when bedtime moves earlier.

Morning daylight can help support an earlier sleep schedule. Spending time outside once it is light is one practical step, although people differ in when they naturally feel sleepy and alert.

What does sleep loss mean for testosterone?

Testosterone is one area researchers have investigated, although the findings do not justify claiming that a 3 a.m. alarm causes low testosterone.

A small University of Chicago study published in 2011, involving 10 healthy young men, found daytime testosterone levels were approximately 10% to 15% lower after about a week of sleep restricted to five hours a night, compared with a longer sleep condition.

However, two randomized studies published together in 2019 did not find an adverse effect on testosterone under the sleep-restriction conditions they tested. The studies used different schedules and measurements, and neither paper tested the social media trend itself.

The evidence supports taking sleep seriously without assuming that tiredness automatically signals a hormone problem.

Wyoming, Alaska and Montana lead searches for testosterone therapy

Separately, Feel30’s analysis of 312 testosterone replacement therapy (TRT) search terms recorded a combined estimated U.S. search volume of 3.37 million between September 2025 and August 2026.

Wyoming had the highest estimated search rate relative to population, followed by Alaska and Montana.

RankStateEstimated annual searches per 100,000 residents
1Wyoming3,093.0
2Alaska2,575.7
3Montana2,336.9
4North Dakota2,298.1
5Hawaii2,174.0
6South Dakota2,091.8
7Delaware2,056.7
8New Hampshire2,041.2
9Vermont2,029.0
10Rhode Island2,011.6

Rates use total state populations. Figures estimate searches, not individual searchers, patients or diagnoses.

Wyoming’s rate was almost three times California’s 1,045.7 searches per 100,000 residents. California recorded the largest total estimated volume, at 411,520, but ranked 41st once population was taken into account.

The rankings show geographic differences in search activity. They do not identify the states with the lowest testosterone, and the analysis did not measure sleep habits or establish any connection with early waking.

When tiredness needs checking

Persistent tiredness deserves a medical assessment, especially alongside loud snoring, gasping during sleep or breathing that stops and starts. These can be signs of sleep apnea.

Tiredness alone cannot diagnose low testosterone. The Endocrine Society recommends diagnosis only when compatible symptoms and signs are accompanied by consistently low testosterone levels, confirmed through repeat morning fasting blood tests. Treatment decisions require an appropriate clinical assessment.

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Wellness

Structured exercise linked to longer cancer survival and time free of disease

Those who exercised as part of their care were 23% less likely to die and 17% less likely to have a recurrence before death than those who didn’t exercise. Separate analyses showed that they were also 18% less likely to die from any cause, and 26% less likely to die from their cancer.

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Structured exercise may help people with cancer live longer and have more time free of disease, finds a synthesis of the available evidence, published in the British Journal of Sports Medicine.

The survival and recurrence risk benefits were strongest in early stage disease, in those who did aerobic exercise or aerobic exercise plus strength training, and in those who managed to keep up their exercise routines, the findings indicate.

Their analysis prompts the researchers to conclude that incorporating the therapeutic potential of exercise into cancer care merits consideration.

Cancer comes back in between 20%–40% of patients, even after standard curative surgery and chemotherapy, point out the researchers.

While structured exercise is widely recommended to ease fatigue and improve physical functioning and quality of life, its potential to prolong survival and stave off disease recurrence remains a subject of debate, they add.

In a bid to strengthen the evidence base, the researchers scoured research databases for randomised controlled clinical trials published up to the end of 2025 and reporting on survival and disease recurrence in adults with confirmed cancer who were given structured exercise programmes as part of their care.

From an initial haul of 123 studies, 21 clinical trials from North America, Europe, Australia, and Asia, involving a total of 8449 participants (88% women), met the eligibility criteria.

The average age of participants was 54 (range 47–76), and the average monitoring period was 64 months (range 2–99 months). The most common type of cancer studied was that of the breast followed by those of the bowel and pancreas.

Pooled data analysis of the results showed that structured exercise was associated with significant improvements in overall survival.

Those who exercised as part of their care were 23% less likely to die and 17% less likely to have a recurrence before death than those who didn’t exercise. Separate analyses showed that they were also 18% less likely to die from any cause, and 26% less likely to die from their cancer.

But there was no clear evidence that structured exercise prolonged the time before patients’ cancer worsened or increased the likelihood that no invasive cancer remained after standard treatment.

An exploratory analysis showed that the associations were stronger among participants who completed at least 70% of their exercise programme.

Overall survival estimates favoured aerobic exercise alone and programmes combining aerobic exercise and strength training. No clear association was found for strength training alone, but this finding was based only on one trial, involving 129 participants, note the researchers

“Aerobic exercise drives systemic cardiovascular conditioning, immune cell mobilisation, and normalisation of tumour perfusion, mechanisms directly relevant to systemic tumour control,” explain the researchers.

There are plausible biological explanations for the beneficial effects of exercise on cancer survival and risk of recurrence, they suggest.

Exercise may boost the body’s immune system response to cancer and improve blood flow within tumours, potentially helping treatment to work better. It may also lower circulating levels of sex specific hormones and increase glucose uptake by muscles, leaving less available to fuel cancer cells, they highlight. And it may help cells repair DNA damage, potentially limiting changes that can make tumours more aggressive, they add.

The researchers acknowledge various limitations to their findings, including the migration of participants in comparison groups to healthier behaviours; considerable variations in the type, duration, and intensity of the included exercise interventions; and a predominance of evidence from breast cancer trials, with relatively little evidence on advanced stage disease.

Nevertheless, they conclude: “Our meta-analysis provides direct, quantified evidence suggesting that the benefits of structured exercise may extend beyond supportive care to outcomes traditionally associated with therapeutic interventions, while underscoring that observed effects are context dependent and sensitive to trial design, conduct, and feasibility.”

They add: “On the strength of this evidence, clinicians can reasonably recommend structured exercise as part of oncological care, while recognising that important questions remain and that ongoing trials will continue to refine its optimal application.”

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Workout or nap? Either can help your sleepless brain, study finds

People who either completed 20 minutes of moderate-to-vigorous exercise or took a 90-minute nap performed about 22 per cent better on memory tests after 30 hours without sleep than those who did neither.

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A short workout or a nap can help protect memory after a sleepless night, a McGill University-led study has found.

Researchers found people who either completed 20 minutes of moderate-to-vigorous exercise or took a 90-minute nap performed about 22 per cent better on memory tests after 30 hours without sleep than those who did neither. The findings, published in Proceedings of the National Academy of Sciences (PNAS), point to practical ways to counter the effects of sleep deprivation.

“Sleep loss affects nearly every aspect of how we think and function, but many people can’t simply stop what they’re doing and get more sleep,” said senior author Marc Roig, Professor in McGill’s School of Physical and Occupational Therapy. “Our findings show that even a brief bout of exercise may help preserve one of our most important cognitive abilities.”

The study involved 54 healthy young adults who stayed awake for 30 consecutive hours under lab supervision. Participants were then assigned to one of three groups: a 20-minute cycling session, a 90-minute nap or a control condition. Three days later, researchers tested their memory for images they had viewed immediately after the intervention. Those who exercised or napped remembered significantly more images than participants who did neither.

Same result, different pathways

While the memory benefits were nearly identical, brain recordings revealed that exercise and napping helped in different ways.

Napping appeared to help the brain recharge, making it easier to take in and remember new information. Exercise, by contrast, helped the brain use its remaining resources more efficiently, without making participants feel more tired.

The findings could eventually inform fatigue-management strategies in workplaces where sleep loss is common and mistakes can have serious consequences, such as health care, transportation and emergency response.

“A nap isn’t always possible in the middle of a shift,” said first author Madhura Lotlikar, a doctoral candidate in McGill’s Department of Neurology and Neurosurgery. “Exercise is accessible, inexpensive and easy to implement. That makes it a promising tool to help people stay cognitively sharp when sleep is limited.”

The researchers emphasize that exercise cannot replace sleep, but it may help people function better when getting enough rest isn’t possible.

About the study

“Protecting episodic memory after sleep loss: Similar benefits of exercise and naps via distinct neural contributions” by Madhura Lotlikar and Marc Roig et al., was published in Proceedings of the National Academy of Sciences of the United States of America.

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