NewsMakers
Positive life outlook may protect against middle-aged memory loss, 16-year study suggests
Those who said they had higher wellbeing were more likely to subsequently have better scores on memory tests.
Higher levels of wellbeing may help reduce the risk of memory loss in middle age, suggests new research, which tracked more than 10,000 over 50-year-olds across a 16-year span.
Findings that are published in the peer-reviewed journal Aging & Mental Health found those who said they had higher wellbeing were more likely to subsequently have better scores on memory tests.
These people – all of whom were determined as having ‘healthy brains’ – also reported a greater sense of control, independence, and freedom to make choices.
This association between psychological wellbeing and better recall was small but significant. The link was also independent of depressive symptoms, according to the researchers.
However, the analysis by a cohort of 15 experts across the UK, US and Spain found no evidence to suggest better memory was linked with later higher wellbeing, although the authors say the possibility cannot be discounted.
The academics add that the results highlight that psychological and social factors affect brain health, and wellbeing may protect against cognitive impairment. Interventions to promote psychological wellbeing such as mindfulness could maintain mental functions such as memory as people age.
“In the context of an ageing population, understanding factors that may protect and maintain healthy cognitive function is critical for enhanced population health and health policy development,” explains lead author Dr Amber John, a Lecturer in Psychology at the University of Liverpool and a current Alzheimer’s Research UK Fellow, who specialises in research on ageing, with a specific focus on mental health, neurodivergence, and dementia.
“While, in this research, we can’t examine and understand the relationship between causes and effects, determining if one event leads to another (causality), our findings are important in proposing that good wellbeing predates better memory rather than vice versa. This suggests that the link between wellbeing and memory is not just because people with poor memory have poor wellbeing and that, if causality is demonstrated, improving wellbeing could protect against subsequent memory decline.”
Co-author Joshua Stott, a Professor of Ageing and Clinical Psychology at UCL, adds: “This study represents an important step toward understanding the interplay between wellbeing and memory over time. It offers new insights into how self-rated wellbeing is associated with memory and vice versa.
“While our findings are preliminary, they highlight the importance of considering psychosocial influences on brain health such as memory.”
Depression and anxiety are widely recognised as risk factors in faster decline of brain health and dementia. A key global healthcare priority is now to prevent dementia.
Wellbeing is defined as emotional health combined with being able to function effectively. Happiness, confidence, a sense of purpose and control over life are among the elements of wellbeing.
Existing studies have suggested a positive link between wellbeing, age-related decline in mental processes in the brain, and mild impairment of these functions. Memory is regarded as a cornerstone of an individual’s mental processes.
However, most studies have only tested this link between wellbeing and memory in one direction or another. The aim of this research was to provide longer-term insights into the relationship between wellbeing and memory in people who have yet to experience significant cognitive decline.
Data was based on 10,760 men and women who took part in the English Longitudinal Study of Ageing Self-reported. This existing long-term research project involves UK adults over the age of 50 and includes attitudes to well-being.
Participants were assessed on wellbeing and memory every two years – a total of nine times during the 16-year study period stretching back to 2002.
Researchers used a learning task to check participants’ ability to recall ten words immediately and after a delay. Wellbeing was assessed using a quality-of-life questionnaire. Participants scored themselves based on satisfaction of specific needs – pleasure, control, autonomy, and self-realisation. Questions included ‘I can do the things that I want to do’, and ‘I feel that life is full of opportunities’.
The authors excluded anyone with a dementia diagnosis at the start of the study.
Results showed a small but significant association between higher wellbeing and better memory. In addition, the study found that the impact of wellbeing on memory was significant even after adjusting for depression. The authors say this suggests links between wellbeing and memory exist independent from depressive symptoms.
Biological factors such as cardiovascular disease and those linked to lifestyle – such as physical activities – are among possible reasons for the effect of wellbeing on memory, say the authors. Age, gender, lifestyle, and socioeconomic status may also have a negative or positive impact on the relationship between wellbeing and memory function.
Despite the lack of evidence for memory affecting wellbeing, the authors say this cannot be ruled out. They say lower psychological wellbeing may be a sign of ‘oncoming cognitive impairment’ before symptoms become apparent.
The research was funded by Alzheimer’s Research UK; Medical Research Council (a part of UKRI); National Institute on Aging; and National Institute for Health and Care Research (NIHR).
Emma Taylor, Information Services Manager at Alzheimer’s Research UK, comments: “Loving your heart, staying sharp and keeping connected are key to protecting our brain health as we age.
“There are 14 established health and lifestyle risk factors for dementia, including lack of physical exercise, social isolation, and depression, which are linked to wellbeing.
“This study found that people over 50 who reported they felt happier and more fulfilled in life had a better memory over time. However, this research is observational – and more work is needed to understand how a positive wellbeing and memory are connected and whether this has a knock-on effect on dementia risk.
“Looking after our mental wellbeing plays an important part in our overall health. And it’s never too late to start taking steps to keep our brains healthy throughout our lives and lessen the devastating impact of dementia.”
As with all long running longitudinal studies, one limitation of this paper is sample attrition over the follow-up period. However, the team used a research methodology which enabled use of use of all available information in the observed data, without imputation or discarding cases.
To conclude, authors say their results could provide the basis for further research into what factors can enhance brain health in aging populations.
Co-author Dr Emily Willroth, an Assistant Professor of Psychological & Brain Sciences at Washington University, in St Louis, Missouri, adds: “Going forwards it would be fantastic if this research can build on the foundations of ongoing memory research to potentially inform strategies supporting cognitive health in ageing populations – that is the aim.”
NewsMakers
The look and feel of your neighborhood may affect your sleep
Those living in neighborhoods rated as having a stronger sense of safety tended to sleep longer, and that this rating appeared to be shaped by the streetscape.
Your neighborhood’s “streetscape”—the physical environment of your street—is something that you have probably never consciously thought about, despite seeing it every day. But what if the streetscape was affecting you on a subconscious level and disrupting your sleep?
This intriguing question is posed by the findings of a study led by Professor Daisuke Matsushita of the Graduate School of Human Life and Ecology at Osaka Metropolitan University. The research team used AI to analyze more than 200,000 Google Street View images to identify visual neighborhood characteristics. They then linked these characteristics to the self-reported sleep of 1,089 working adults living on the lower floors of apartments in Tokyo, who were most likely to be affected by the streetscape.
They found that those living in neighborhoods rated as having a stronger sense of safety tended to sleep longer, and that this rating appeared to be shaped by the streetscape. Generally, people slept longer in areas with lots of greenery, such as leafy trees, on the street. Similarly, high “enclosure”—meaning many tall vertical buildings and few wide-open spaces—was also associated with longer sleep and fewer insomnia symptoms.
However, the study also made a surprising finding. The researchers found that highly walkable streetscapes, such as those with more sidewalks and traffic signs, were associated with a lowered sense of safety and shortened sleep duration.
This suggests that walkability does not always represent a reassuring environment. Instead, a possible explanation is that streets with extensive pedestrian infrastructure are often busier, more crowded, and used by more strangers, which may be perceived as less safe or less relaxing than quieter residential streets.
“This study demonstrates the potential for evaluating streetscape characteristics across large geographic areas in a cost-effective manner,” Dr. Matsushita said. “Based on the technique used in this study, cities could potentially measure perceived safety, beauty, liveliness, and enclosure as well as pollution and noise.”
“We hope that opening up this new perspective creates further possibilities for designing healthier neighborhoods,” he concludes.
The findings were published in Building and Environment.
NewsMakers
Workout or nap? Either can help your sleepless brain, study finds
People who either completed 20 minutes of moderate-to-vigorous exercise or took a 90-minute nap performed about 22 per cent better on memory tests after 30 hours without sleep than those who did neither.
A short workout or a nap can help protect memory after a sleepless night, a McGill University-led study has found.
Researchers found people who either completed 20 minutes of moderate-to-vigorous exercise or took a 90-minute nap performed about 22 per cent better on memory tests after 30 hours without sleep than those who did neither. The findings, published in Proceedings of the National Academy of Sciences (PNAS), point to practical ways to counter the effects of sleep deprivation.
“Sleep loss affects nearly every aspect of how we think and function, but many people can’t simply stop what they’re doing and get more sleep,” said senior author Marc Roig, Professor in McGill’s School of Physical and Occupational Therapy. “Our findings show that even a brief bout of exercise may help preserve one of our most important cognitive abilities.”
The study involved 54 healthy young adults who stayed awake for 30 consecutive hours under lab supervision. Participants were then assigned to one of three groups: a 20-minute cycling session, a 90-minute nap or a control condition. Three days later, researchers tested their memory for images they had viewed immediately after the intervention. Those who exercised or napped remembered significantly more images than participants who did neither.
Same result, different pathways
While the memory benefits were nearly identical, brain recordings revealed that exercise and napping helped in different ways.
Napping appeared to help the brain recharge, making it easier to take in and remember new information. Exercise, by contrast, helped the brain use its remaining resources more efficiently, without making participants feel more tired.
The findings could eventually inform fatigue-management strategies in workplaces where sleep loss is common and mistakes can have serious consequences, such as health care, transportation and emergency response.
“A nap isn’t always possible in the middle of a shift,” said first author Madhura Lotlikar, a doctoral candidate in McGill’s Department of Neurology and Neurosurgery. “Exercise is accessible, inexpensive and easy to implement. That makes it a promising tool to help people stay cognitively sharp when sleep is limited.”
The researchers emphasize that exercise cannot replace sleep, but it may help people function better when getting enough rest isn’t possible.
About the study
“Protecting episodic memory after sleep loss: Similar benefits of exercise and naps via distinct neural contributions” by Madhura Lotlikar and Marc Roig et al., was published in Proceedings of the National Academy of Sciences of the United States of America.
NewsMakers
Study links coffee consumption to metabolic health and sex hormones
Despite having a similar body mass index (BMI), individuals with higher coffee consumption had lower total and visceral fat and greater skeletal muscle mass than those who consumed less coffee.
Coffee is one of the world’s most widely consumed beverages, and previous research has linked its consumption to a lower risk of conditions such as type 2 diabetes and cardiovascular disease. However, the biological mechanisms behind these benefits remain unclear. A new Finnish study links habitual coffee consumption to healthier body composition and metabolic markers, while revealing distinct associations with sex hormones in men and women.
The study, conducted at the University of Oulu, analysed data from 2,264 participants aged 46 in the Northern Finland Birth Cohort 1966. Researchers examined how habitual coffee consumption was associated with circulating metabolites, cardiometabolic risk markers and sex hormones.
Despite having a similar body mass index (BMI), individuals with higher coffee consumption had lower total and visceral fat and greater skeletal muscle mass than those who consumed less coffee.
In both men and women, higher coffee consumption was correlated with lower circulating levels of branched-chain amino acids, biomarkers that have previously been linked to insulin resistance and an increased risk of type 2 diabetes when chronically elevated.
The strongest sex-specific associations were observed in men. Higher coffee consumption was linked to a more favourable glucose–insulin profile, higher concentrations of total and bioavailable testosterone, and increased levels of sex hormone-binding globulin (SHBG). At the same time, free testosterone and the free androgen index were modestly lower. In women, hormonal associations were more limited and were primarily characterised by higher SHBG and lower measures of free androgens.
“Coffee is consumed by millions of people every day, yet we still know surprisingly little about how it relates to our metabolism and hormones. What stood out in our findings was a distinct hormonal signature that didn’t disappear even after we took into account BMI and lifestyle factors, with several of these associations differing between men and women,” says Luca Verroest, lead author of the study and Doctoral Researcher at the University of Oulu.
The results suggest that hormonal pathways may partly explain the relationship between coffee consumption and metabolic health. However, as this was an observational study, the findings demonstrate associations rather than cause-and-effect relationships.
The study is particularly relevant in Finland, one of the world’s highest coffee-consuming countries, where annual consumption averages around 11.8 kilograms per person.
The researchers say the findings provide a foundation for future studies aimed at determining whether coffee itself drives these biological changes and identifying the compounds responsible. These questions are currently being investigated in animal models, with the long-term goal of progressing to human intervention studies. Further research will be needed before the findings could inform dietary recommendations.
The study, Associations of habitual coffee intake with testosterone and cardiometabolic markers: the Northern Finland Birth Cohort 1966 study, has been published in the European Journal of Nutrition.
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