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Cancer risk is significantly higher for adults who never married, large study finds
Adults who were never married had substantially higher rates of developing cancer compared with those who were or had been married. For some cancers, the association was even stronger: adult men who were never married had approximately five times the rate of anal cancer compared with married men.
Adults who have never been married face a significantly higher risk of developing cancer than those who have been married, according to a study of more than 4 million cases.
The increased risk spans nearly every major cancer type and is especially pronounced for preventable cancers—those linked to infections, smoking and reproductive factors. Led by researchers at Sylvester Comprehensive Cancer Center, part of the University of Miami Miller School of Medicine, the study appears in the April 8 issue of Cancer Research Communications.
A link to the article is here.
“These findings suggest that social factors such as marital status may serve as important markers of cancer risk at the population level,” said Paulo Pinheiro, Ph.D., study co-author and a Sylvester physician-scientist whose lab conducts population-based cancer epidemiology.
The novel observation does not mean that getting married prevents cancer or that people need to get married.
“It means that if you’re not married, you should be paying extra attention to cancer risk factors, getting any screenings you may need, and staying up to date on health care,” said Frank Penedo, Ph.D., associate director for population sciences and director of the Sylvester Survivorship and Supportive Care Institute (SSCI).
“For prevention efforts, our findings point to the importance of targeting cancer risk awareness and prevention strategies with attention to marital status,” he added.
Marriage is already associated with earlier cancer diagnosis and better survival. Married individuals often, but not always, have stronger support systems, greater economic stability and are more likely to adhere to cancer treatment regimens.
But previous work on the links between marriage and cancer focused almost entirely on what happens at and after diagnosis. Only a few small, older studies explored whether marriage affects the odds of getting cancer in the first place.
“We wanted to know who is more likely to get cancer: married people or unmarried people?” Pinheiro said.
To find out, the researchers analyzed a large dataset covering 12 states that included demographic and cancer data from more than 4 million cancer cases in a population of more than 100 million people, collected between 2015 and 2022. They examined cases of malignant cancers diagnosed at age 30 or older and compared rates of various cancers by marital status, further broken down by sex and race and adjusted for age.
The researchers categorized marital status into two groups: those who were or had been married, including married, divorced and widowed individuals, and those who had never been married. The study began in 2015 because that year, the U.S. Supreme Court legalized gay marriage, allowing same-sex couples to be included in the married category. One in five adults in the study had never married.
Pinheiro expected to see some associations, given established relationships between marriage and lifestyle factors such as smoking, routine medical care and having children. But the strength of some findings surprised him.
Adults who were never married had substantially higher rates of developing cancer compared with those who were or had been married. For some cancers, the association was even stronger: adult men who were never married had approximately five times the rate of anal cancer compared with married men. Adult women who were never married had nearly three times the rate of cervical cancer compared with women who were or had been married.
Both anal and cervical cancers are strongly related to HPV infection, so these differences likely reflect variation in exposure, and for cervical cancer, also differences in screening and prevention. In contrast, for cancers such as endometrial and ovarian, differences by marital status may partly reflect the protective effect of parity, which is more common among married individuals.
“It’s a clear and powerful signal that some individuals are at a greater risk,” Penedo said.
Men and women showed slightly different patterns. Men who were never married were about 70% more likely to develop cancer than married men, while women who never married were about 85% more likely to develop cancer than women who were or had been married.
This represents a small but noteworthy reversal of a broader trend: Men often benefit more from marriage than women in terms of health and social factors. In this case, women appeared to benefit slightly more from marriage than men.
The strongest associations between marriage and cancer were seen for cancers related to infection, smoking or alcohol use, and, for women, cancers related to reproduction, such as ovarian and endometrial cancer.
The researchers found weaker associations for cancers with robust screening programs, including breast, thyroid and prostate cancers.
They also observed patterns across race and marital status. Black men who were never married had the highest overall cancer rates. However, married Black men had lower cancer rates than married White men, indicating a strong protective association with marriage in that group.
The study has limitations. People who smoke less, drink less, take better care of themselves and are more socially integrated may also be more likely to get married.
Still, the researchers found that associations between marriage and cancer were stronger in adults older than 50, suggesting that as people age and accumulate cancer risk exposures, the benefits associated with marriage may become more pronounced.
The study also excluded individuals who are unmarried but in committed partnerships. That group is likely small relative to the size of the dataset, Pinheiro said, but worth exploring in future research.
Future studies could further subdivide the married category into married, divorced and widowed individuals and follow people over decades to better understand how marital transitions affect cancer risk.
Overall, getting married does not magically prevent cancer, both authors stressed.
“But the association between marriage status and cancer risk is an interesting, new observation that deserves more research,” Pinheiro said.
NewsMakers
For weight loss, where food comes from may matter as much as how it is processed
Processed and ultra-processed animal foods tended to track with weight gain, and minimally processed plant foods with weight loss, although these associations were weaker. Ultra-processed plant foods were not associated with weight change.
Eating more meat, fish, eggs, and dairy products was associated with weight gain even when those foods were minimally processed, according to a study from the Physicians Committee for Responsible Medicine published in Nutrition Research. Minimally processed plant foods, such as fruits, vegetables, whole grains, and beans, showed the opposite pattern.
“Ultra-processed foods get most of the blame for weight gain, but our results suggest we also need to ask whether a food comes from a plant or an animal,” says lead author Hana Kahleova, MD, PhD, director of clinical research at the Physicians Committee. “A chicken breast is minimally processed. So is an apple. In our study, they did not move the scale in the same direction.”
The researchers analyzed data from a randomized crossover trial in which 62 adults with overweight followed a Mediterranean diet, rich in olive oil, fish, and nuts, and a low-fat vegan diet for 16 weeks each, separated by a four-week washout. Participants kept three-day diet records, and every food was classified by degree of processing, using the NOVA system, and by whether it came from a plant or an animal.
Compared with the Mediterranean diet, the vegan diet cut minimally processed animal foods by 135 grams per day more and raised minimally processed plant foods by 202 grams per day more. Processed animal and plant foods also fell more on the vegan diet. Across both diets, eating more minimally processed animal foods was linked to weight gain; this was the strongest association in the analysis and the only one to remain statistically significant after correction for multiple comparisons.
Processed and ultra-processed animal foods tended to track with weight gain, and minimally processed plant foods with weight loss, although these associations were weaker. Ultra-processed plant foods were not associated with weight change.
In the main trial, published in 2022, participants lost an average of 6 kilograms (about 13 pounds) on the vegan diet, with no change on the Mediterranean diet. Minimally processed plant foods are high in fiber and water and low in calorie density, which helps people feel full on fewer calories.
“If you want to lose weight, fill your plate with beans, vegetables, fruits, and whole grains, and leave the animal products off,” says Dr. Kahleova. “The degree of processing still matters, but it is not the whole story.”
NewsMakers
Mindfulness and self-compassion can alleviate premenstrual symptoms
It is estimated that PMS affects approximately 20-30% of menstruating people, while PMDD impacts 3-8%. The scale of the problem is significant, yet the psychological factors that protect against the development of these symptoms have not been thoroughly investigated.
A kind attitude toward oneself and practicing mindfulness can improve functioning in individuals who experience severe premenstrual symptoms, according to a study by psychologists from SWPS University and Jagiellonian University.
Premenstrual syndrome (PMS) and its more severe form, premenstrual dysphoric disorder (PMDD), cause distressing psychological and physical symptoms, including mood swings, fatigue, concentration difficulties, headaches, and muscle pain. These ailments occur during the second phase of the menstrual cycle and interfere with daily functioning, affecting education, work, relationships, and overall quality of life.
Up to 30 percent of women affected
It is estimated that PMS affects approximately 20-30% of menstruating people, while PMDD impacts 3-8%. The scale of the problem is significant, yet the psychological factors that protect against the development of these symptoms have not been thoroughly investigated.
The study, published in “Psychology and Psychotherapy: Theory, Research and Practice”, is part of a broader project analysing potential mechanisms and factors that may protect against the onset of PMS and PMDD. In a new study, Rachela Antosz-Rekucka, PhD, a psychologist at the Institute of Psychology at SWPS University, and Katarzyna Prochwicz, PhD, a professor at the Institute of Psychology of the Jagiellonian University, analysed factors that might protect against the onset of severe premenstrual symptoms. They examined variables such as the sense of coherence, mindfulness skills, and self-compassion, and investigated their relationship with past trauma, perceived stress levels, and symptoms of premenstrual disorders.
The study involved 228 participants aged 18 to 52. They were asked about their past experiences with premenstrual symptoms, and a part of the group subsequently tracked their symptoms over the course of two menstrual cycles.
Self-compassion and mindfulness help alleviate symptoms
The results suggest that higher levels of certain psychological resources can moderate the negative effect of stress and trauma on the severity of menstrual cycle-related symptoms.
Specific psychological attitudes may noticeably reduce the impact of daily stress on the severity of premenstrual symptoms. These include a kind attitude toward oneself and the acceptance of difficult moments, known as self-compassion. This approach helps women to navigate the challenging phases of their cycle more easily, even during times of intense nervous tension, says Rachela Antosz-Rekucka of SWPS University, who conducted the study as part of her doctoral research at the Jagiellonian University.
Practicing mindfulness (directing one’s attention to the present moment without judgment or worry) can also offer relief. In the context of PMS and PMDD, refraining from judging one’s own emotional reactions is particularly helpful, as it prevents the magnification of perceived discomfort. Furthermore, individuals with a strong sense of coherence cope better with rising premenstrual stress.
Past trauma and premenstrual symptoms
For individuals with a history of trauma, the ability to precisely describe their internal states and feelings, combined with the capacity to avoid judging their own emotional reactions, can help mitigate the negative impact of that trauma on premenstrual symptoms.
Psychological resources boost stress resilience
The results of the study could be significant for many people who menstruate. These findings could pave the way for modern therapeutic programs based on approaches such as mindfulness training or self-compassion-focused therapy, potentially reducing the reliance on medication.
The study suggests that more understanding, mindful, and compassionate attitude towards oneself may benefit individuals with severe premenstrual symptoms. PMS and PMDD are chronic conditions, which is why interventions such as mindfulness-based therapy, compassion-focused therapy, or strategies oriented at enhancing the sense of coherence, may help individuals navigate their conditions more effectively, and possibly increase their overall quality of life, Rachela Antosz-Rekucka emphasises.
NewsMakers
Music can enhance the flavor of your food
The brain does not create flavor based solely on signals from the tongue.
The moment we take a sip of our morning coffee or our first bite of lunch, the brain begins interpreting what we taste. Is it sweet? Sour? Or something else entirely?
But the brain does not create flavor based solely on signals from the tongue. That is the finding of a new study from the Department of Food Science, published in the scientific journal Scientific Reports.
“When music reaches the ears at the same time as we are eating, we can see that the brain responds more strongly than when taste is experienced without music,” says first author and postdoctoral researcher Alberte Baggesgaard Seeberg from the Department of Food Science.
Using brain scans, the researchers show that music can activate some of the same brain regions involved in processing taste.
“This tells us that flavour is not simply a property of food. Flavor is an experience created by the brain,” says senior author and associate professor Janice Wang.
A breakthrough in brain imaging
This is the first time researchers have used brain imaging to show what happens in the brain when it processes taste. In the study, they used functional magnetic resonance imaging (fMRI), which measures activity in different parts of the brain by detecting changes in blood flow.
“This allows us to move beyond simply asking people about their experiences, which has been the approach in previous studies. With brain scans, we gain a biological window into what happens when the senses interact,” says Alberte Baggesgaard Seeberg.
While participants lay in the scanner, their brain activity was measured under different conditions. In some cases, they listened only to music. In others, they tasted flavor solutions. In some trials, music and taste were presented simultaneously. This enabled the researchers to compare how the brain responds to sound and taste separately and in combination.
The results clearly showed that certain brain regions were more active when participants listened to music while tasting one of the two flavor solutions.
“We can see that flavor is constructed by the brain and not only by the taste buds. What determines flavor is not limited to what happens on the tongue. It emerges through the integration of multiple senses,” says Janice Wang.
The findings build on previous studies showing that music can enhance particular taste perceptions. For example, slow pop music with harmonious tones may enhance sweetness. Until now, however, this has only been investigated through behavioral studies in which participants rated flavours with and without music.
Shaping flavor experiences could improve wellbeing
According to the researchers, the new knowledge could be used to design better eating experiences in a range of settings, including restaurants, canteens and hospitals.
“For people who are at risk of malnutrition, something as simple as music could potentially improve the eating experience. There is a great deal we can do, often at very little cost, to improve quality of life for some people,” says Alberte Baggesgaard Seeberg.
Janice Wang is pleased that, after many years of research into flavour and sensory perception, the team can now present biological evidence of how the senses interact.
“We now have a new way of influencing flavor perception, creating a better meal experience and potentially a better overall experience, without necessarily changing the food itself,” she says.
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