NewsMakers
Scientific advisory body proposes R&D areas in fight against COVID-19
Amidst the COVID-19 pandemic,the National Academy of Science and Technology has issued a statement declaring its full support for the current research initiatives of the government and the Department of Science and Technology; and has proposed areas that need to be researched to address the problem.
“In the face of limited resources and paucity of knowledge concerning the virus and the disease it causes, researches are being developed and implemented in collaboration with various research groups both here and abroad to address various aspects of the CoViD19 problem. In the light of all these, we propose that the following researches be done or enhanced to identify and implement the most effective measures to address problem of CoViD 19 in the following areas,” said the statement.
In the statement, the NAST offered the following proposals:
1) In the area of epidemiology, modelling studies, which are mostly mathematical, may help us better understand how the epidemic will evolve. Input of health data into these disease models, as the epidemic progresses, will be very important to provide government planners scientific projections on how this epidemic will progress. The data generated will be very helpful in forward planning by concerned government agencies to anticipate, prepare and dampen the effects of this epidemic on different aspects of national life, including the economy.
2) In the area of diagnostics, whereas current tests are focused on the detection of the virus in affected patients, tests determining the presence of antibodies mounted by the human hosts should also be developed. These antibody-based assays will help determine the patients who were truly infected, whether symptomatic or asymptomatic. It may catch the cases missed by the tests for detecting infection as these tests may have been done too early or too late in the disease. The tests to detect antibodies will determine the true burden of disease and as well as provide added information on the infectiousness, transmission dynamics and progression of the disease. These tests may also be used for predicting chances for development of complications as well as mortality, especially if the antibodies are proven to be neutralizing antibodies.
3) In the area of therapy, the country should participate in clinical trials that would have already been initiated by other countries to help us better understand patient responses to this therapy and determine whether different genetic backgrounds, cultures and environment may affect patient response. Moreover, participation in these multi-country studies can facilitate its availability in our country when the results become significant.
4) In the area of prevention and the development of vaccines, knowing more about the virus, its genetic makeup and how fast it mutates or changes will accelerate its development. Characterizing the molecular and genetic structure as isolated from patients in the Philippines can be contributed to the international database that will serve as references for vaccine development. This will ensure that the vaccines developed can induce protection against all of the circulating SarsCoV2 viruses isolated from patients anywhere else in the world.
5) In the area of host factors, genetic biomarkers may be identified that may either predispose or make people less susceptible to the infection. They may also be used to determine risk for severity of disease and complications.
In all of these initiatives, sharing of information within and among scientists, researchers and institutions both here and abroad will help us build on each others’ strengths and accelerate the race for finding the solutions and the answers to many of our questions.
Ultimately, winning the battle would depend on how much and how good we understand our adversary- the Covid19 and the virus that causes it. To many, the virus is like an unknown enemy that works silently easing its way among and through susceptible populations, evading detection and prevention. The experiences of many countries, whether good or bad, will serve as valuable learnings for all of us. For one thing is certain, this epidemic will not be the only ones we will be confronting in the years to come. It has been established by scientists that in the area of zoonotic diseases that start from animal hosts before reaching humans, only half of viruses have been identified. Scientific research and development remain our most effective weapon to confront them and the SARS CoV2.
NewsMakers
The look and feel of your neighborhood may affect your sleep
Those living in neighborhoods rated as having a stronger sense of safety tended to sleep longer, and that this rating appeared to be shaped by the streetscape.
Your neighborhood’s “streetscape”—the physical environment of your street—is something that you have probably never consciously thought about, despite seeing it every day. But what if the streetscape was affecting you on a subconscious level and disrupting your sleep?
This intriguing question is posed by the findings of a study led by Professor Daisuke Matsushita of the Graduate School of Human Life and Ecology at Osaka Metropolitan University. The research team used AI to analyze more than 200,000 Google Street View images to identify visual neighborhood characteristics. They then linked these characteristics to the self-reported sleep of 1,089 working adults living on the lower floors of apartments in Tokyo, who were most likely to be affected by the streetscape.
They found that those living in neighborhoods rated as having a stronger sense of safety tended to sleep longer, and that this rating appeared to be shaped by the streetscape. Generally, people slept longer in areas with lots of greenery, such as leafy trees, on the street. Similarly, high “enclosure”—meaning many tall vertical buildings and few wide-open spaces—was also associated with longer sleep and fewer insomnia symptoms.
However, the study also made a surprising finding. The researchers found that highly walkable streetscapes, such as those with more sidewalks and traffic signs, were associated with a lowered sense of safety and shortened sleep duration.
This suggests that walkability does not always represent a reassuring environment. Instead, a possible explanation is that streets with extensive pedestrian infrastructure are often busier, more crowded, and used by more strangers, which may be perceived as less safe or less relaxing than quieter residential streets.
“This study demonstrates the potential for evaluating streetscape characteristics across large geographic areas in a cost-effective manner,” Dr. Matsushita said. “Based on the technique used in this study, cities could potentially measure perceived safety, beauty, liveliness, and enclosure as well as pollution and noise.”
“We hope that opening up this new perspective creates further possibilities for designing healthier neighborhoods,” he concludes.
The findings were published in Building and Environment.
NewsMakers
Workout or nap? Either can help your sleepless brain, study finds
People who either completed 20 minutes of moderate-to-vigorous exercise or took a 90-minute nap performed about 22 per cent better on memory tests after 30 hours without sleep than those who did neither.
A short workout or a nap can help protect memory after a sleepless night, a McGill University-led study has found.
Researchers found people who either completed 20 minutes of moderate-to-vigorous exercise or took a 90-minute nap performed about 22 per cent better on memory tests after 30 hours without sleep than those who did neither. The findings, published in Proceedings of the National Academy of Sciences (PNAS), point to practical ways to counter the effects of sleep deprivation.
“Sleep loss affects nearly every aspect of how we think and function, but many people can’t simply stop what they’re doing and get more sleep,” said senior author Marc Roig, Professor in McGill’s School of Physical and Occupational Therapy. “Our findings show that even a brief bout of exercise may help preserve one of our most important cognitive abilities.”
The study involved 54 healthy young adults who stayed awake for 30 consecutive hours under lab supervision. Participants were then assigned to one of three groups: a 20-minute cycling session, a 90-minute nap or a control condition. Three days later, researchers tested their memory for images they had viewed immediately after the intervention. Those who exercised or napped remembered significantly more images than participants who did neither.
Same result, different pathways
While the memory benefits were nearly identical, brain recordings revealed that exercise and napping helped in different ways.
Napping appeared to help the brain recharge, making it easier to take in and remember new information. Exercise, by contrast, helped the brain use its remaining resources more efficiently, without making participants feel more tired.
The findings could eventually inform fatigue-management strategies in workplaces where sleep loss is common and mistakes can have serious consequences, such as health care, transportation and emergency response.
“A nap isn’t always possible in the middle of a shift,” said first author Madhura Lotlikar, a doctoral candidate in McGill’s Department of Neurology and Neurosurgery. “Exercise is accessible, inexpensive and easy to implement. That makes it a promising tool to help people stay cognitively sharp when sleep is limited.”
The researchers emphasize that exercise cannot replace sleep, but it may help people function better when getting enough rest isn’t possible.
About the study
“Protecting episodic memory after sleep loss: Similar benefits of exercise and naps via distinct neural contributions” by Madhura Lotlikar and Marc Roig et al., was published in Proceedings of the National Academy of Sciences of the United States of America.
NewsMakers
Study links coffee consumption to metabolic health and sex hormones
Despite having a similar body mass index (BMI), individuals with higher coffee consumption had lower total and visceral fat and greater skeletal muscle mass than those who consumed less coffee.
Coffee is one of the world’s most widely consumed beverages, and previous research has linked its consumption to a lower risk of conditions such as type 2 diabetes and cardiovascular disease. However, the biological mechanisms behind these benefits remain unclear. A new Finnish study links habitual coffee consumption to healthier body composition and metabolic markers, while revealing distinct associations with sex hormones in men and women.
The study, conducted at the University of Oulu, analysed data from 2,264 participants aged 46 in the Northern Finland Birth Cohort 1966. Researchers examined how habitual coffee consumption was associated with circulating metabolites, cardiometabolic risk markers and sex hormones.
Despite having a similar body mass index (BMI), individuals with higher coffee consumption had lower total and visceral fat and greater skeletal muscle mass than those who consumed less coffee.
In both men and women, higher coffee consumption was correlated with lower circulating levels of branched-chain amino acids, biomarkers that have previously been linked to insulin resistance and an increased risk of type 2 diabetes when chronically elevated.
The strongest sex-specific associations were observed in men. Higher coffee consumption was linked to a more favourable glucose–insulin profile, higher concentrations of total and bioavailable testosterone, and increased levels of sex hormone-binding globulin (SHBG). At the same time, free testosterone and the free androgen index were modestly lower. In women, hormonal associations were more limited and were primarily characterised by higher SHBG and lower measures of free androgens.
“Coffee is consumed by millions of people every day, yet we still know surprisingly little about how it relates to our metabolism and hormones. What stood out in our findings was a distinct hormonal signature that didn’t disappear even after we took into account BMI and lifestyle factors, with several of these associations differing between men and women,” says Luca Verroest, lead author of the study and Doctoral Researcher at the University of Oulu.
The results suggest that hormonal pathways may partly explain the relationship between coffee consumption and metabolic health. However, as this was an observational study, the findings demonstrate associations rather than cause-and-effect relationships.
The study is particularly relevant in Finland, one of the world’s highest coffee-consuming countries, where annual consumption averages around 11.8 kilograms per person.
The researchers say the findings provide a foundation for future studies aimed at determining whether coffee itself drives these biological changes and identifying the compounds responsible. These questions are currently being investigated in animal models, with the long-term goal of progressing to human intervention studies. Further research will be needed before the findings could inform dietary recommendations.
The study, Associations of habitual coffee intake with testosterone and cardiometabolic markers: the Northern Finland Birth Cohort 1966 study, has been published in the European Journal of Nutrition.
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