NewsMakers
Eating too much – not exercising too little – may be at core of weight gain, study finds
Conventional wisdom suggests that an increasingly sedentary and germ-free lifestyle, resulting in low daily energy expenditure, is a primary factor underlying rising rates of obesity.
Forager-horticulturalist children in the Amazon rainforest do not spend more calories in their everyday lives than children in the United States, but they do spend calories differently. That finding provides clues for understanding and reversing global trends in obesity and poor metabolic health, according to a Baylor University researcher in a study published in Science Advances.
“Conventional wisdom suggests that an increasingly sedentary and germ-free lifestyle, resulting in low daily energy expenditure, is a primary factor underlying rising rates of obesity,” said Samuel Urlacher, Ph.D., assistant professor of anthropology at Baylor University. “The findings of our study challenge that notion. We demonstrate that Amazonian children with physically active lifestyles and chronic immunological challenges don’t actually burn more calories than much more sedentary children living here in the U.S.”
“This similarity in energy expenditure suggests that the human body can flexibly balance energy budgets in different contexts,” Urlacher said. “Ultimately, eating too much, not moving too little, may be at the core of long-term weight gain and the global nutrition transition that often begins during childhood.”
The study — “Constraint and Tradeoffs Regulate Energy Expenditure During Childhood” — is published in Science Advances, a journal of the American Association for the Advancement of Science.
Standard models in human nutrition assume that habitual energy use is “additive,” such that exercise and other metabolic tasks increase total daily energy expenditure, which is the total number of calories that humans burn each day. Consistently exercise more, spend more total calories. However, that model has been increasingly challenged by studies suggesting that total daily energy expenditure is “constrained” within a relatively narrow human range. Consistently exercise more, spend fewer calories on other metabolic tasks and no extra calories overall. Until now, no research had directly tested these two opposing models of energy use among children living in challenging environments.
To investigate how children spend calories, Urlacher and his colleagues collected energetics data from 44 forager-horticulturalist Shuar children (ages 5 to 12) and compared them to those of industrialized children in the U.S. and the United Kingdom. The Shuar are a population of around 50,000 individuals living in the isolated Amazon region of Ecuador. Without easy access to stores and labor-saving technology, they continue to rely predominantly on a subsistence-based lifestyle of hunting, fishing, foraging and small-scale horticulture. To measure energy expenditure, the researchers used gold-standard isotope-tracking and respirometry methods, the first time that either state-of-the-art approach had been used among children in a subsistence-based population. This new information was coupled with data reflecting physical activity, immune activity, nutritional status and growth.
Results provide strong support for constraint and tradeoffs in children’s energy expenditure. The study found that:
- Shuar children are approximately 25% more physically active than industrialized children.
- Shuar children have approximately 20% greater resting energy expenditure than industrialized children, to a large degree reflecting elevated immune system activity.
- Despite wide differences in lifestyle and energy allocation, the total number of calories that Shuar children spend every day is indistinguishable from that of industrialized children.
“These findings advance previous work among adults, showing that energy expenditure is also constrained during childhood,” said co-author Herman Pontzer, Ph.D., associate professor of evolutionary anthropology at Duke University.
Researchers argue that because tradeoffs underlying energy constraint may often limit physical growth, such constraint has implications for understanding childhood growth faltering and its associated increased risk for adult obesity and metabolic diseases such as Type 2 diabetes and hypertension. Specifically, the findings imply that a high degree of physical and immune activity may reduce energy available for growth, even when food is abundant.
A key takeaway of the study is that rapid change in diet and increasing energy intake, not decreasing physical activity or infectious disease burden, may most directly underlie the chronic weight gain driving the global rise of obesity. However, “Exercise remains critically important for health and for weight management given its effects on appetite, muscle mass, cardiopulmonary function and many other factors,” Urlacher said. “Our results don’t suggest otherwise. Everyone should meet recommended daily physical activity levels.”
The researchers recognize several ways to improve upon their study in the future, including considering a wider age range of children, comparing additional study populations and collecting longitudinal data spanning economic development and lifestyle variation within a single transitioning population. Importantly, the authors will continue to look for ways to better apply their findings to improve health among the Shuar and other populations globally.
Urlacher, a co-director of the long-term Shuar Health and Life History Project, has spent more than 25 months living with the Shuar since 2011.
“I really care about the Shuar,” Urlacher said. “The science is exciting, but, ultimately, we hope that our research can help to improve health among the Shuar, in the U.S. and elsewhere.”
Financial support for the study was provided by the National Science Foundation.
Co-researchers included the Department of Evolutionary Anthropology at Duke University; the Department of Anthropology at the University of Oregon; the Department of Preventive Medicine and Epidemiology at Loyola University; the Department of Anthropology at Northern Arizona University; and the Duke Global Health Institute at Duke University.
NewsMakers
The look and feel of your neighborhood may affect your sleep
Those living in neighborhoods rated as having a stronger sense of safety tended to sleep longer, and that this rating appeared to be shaped by the streetscape.
Your neighborhood’s “streetscape”—the physical environment of your street—is something that you have probably never consciously thought about, despite seeing it every day. But what if the streetscape was affecting you on a subconscious level and disrupting your sleep?
This intriguing question is posed by the findings of a study led by Professor Daisuke Matsushita of the Graduate School of Human Life and Ecology at Osaka Metropolitan University. The research team used AI to analyze more than 200,000 Google Street View images to identify visual neighborhood characteristics. They then linked these characteristics to the self-reported sleep of 1,089 working adults living on the lower floors of apartments in Tokyo, who were most likely to be affected by the streetscape.
They found that those living in neighborhoods rated as having a stronger sense of safety tended to sleep longer, and that this rating appeared to be shaped by the streetscape. Generally, people slept longer in areas with lots of greenery, such as leafy trees, on the street. Similarly, high “enclosure”—meaning many tall vertical buildings and few wide-open spaces—was also associated with longer sleep and fewer insomnia symptoms.
However, the study also made a surprising finding. The researchers found that highly walkable streetscapes, such as those with more sidewalks and traffic signs, were associated with a lowered sense of safety and shortened sleep duration.
This suggests that walkability does not always represent a reassuring environment. Instead, a possible explanation is that streets with extensive pedestrian infrastructure are often busier, more crowded, and used by more strangers, which may be perceived as less safe or less relaxing than quieter residential streets.
“This study demonstrates the potential for evaluating streetscape characteristics across large geographic areas in a cost-effective manner,” Dr. Matsushita said. “Based on the technique used in this study, cities could potentially measure perceived safety, beauty, liveliness, and enclosure as well as pollution and noise.”
“We hope that opening up this new perspective creates further possibilities for designing healthier neighborhoods,” he concludes.
The findings were published in Building and Environment.
NewsMakers
Workout or nap? Either can help your sleepless brain, study finds
People who either completed 20 minutes of moderate-to-vigorous exercise or took a 90-minute nap performed about 22 per cent better on memory tests after 30 hours without sleep than those who did neither.
A short workout or a nap can help protect memory after a sleepless night, a McGill University-led study has found.
Researchers found people who either completed 20 minutes of moderate-to-vigorous exercise or took a 90-minute nap performed about 22 per cent better on memory tests after 30 hours without sleep than those who did neither. The findings, published in Proceedings of the National Academy of Sciences (PNAS), point to practical ways to counter the effects of sleep deprivation.
“Sleep loss affects nearly every aspect of how we think and function, but many people can’t simply stop what they’re doing and get more sleep,” said senior author Marc Roig, Professor in McGill’s School of Physical and Occupational Therapy. “Our findings show that even a brief bout of exercise may help preserve one of our most important cognitive abilities.”
The study involved 54 healthy young adults who stayed awake for 30 consecutive hours under lab supervision. Participants were then assigned to one of three groups: a 20-minute cycling session, a 90-minute nap or a control condition. Three days later, researchers tested their memory for images they had viewed immediately after the intervention. Those who exercised or napped remembered significantly more images than participants who did neither.
Same result, different pathways
While the memory benefits were nearly identical, brain recordings revealed that exercise and napping helped in different ways.
Napping appeared to help the brain recharge, making it easier to take in and remember new information. Exercise, by contrast, helped the brain use its remaining resources more efficiently, without making participants feel more tired.
The findings could eventually inform fatigue-management strategies in workplaces where sleep loss is common and mistakes can have serious consequences, such as health care, transportation and emergency response.
“A nap isn’t always possible in the middle of a shift,” said first author Madhura Lotlikar, a doctoral candidate in McGill’s Department of Neurology and Neurosurgery. “Exercise is accessible, inexpensive and easy to implement. That makes it a promising tool to help people stay cognitively sharp when sleep is limited.”
The researchers emphasize that exercise cannot replace sleep, but it may help people function better when getting enough rest isn’t possible.
About the study
“Protecting episodic memory after sleep loss: Similar benefits of exercise and naps via distinct neural contributions” by Madhura Lotlikar and Marc Roig et al., was published in Proceedings of the National Academy of Sciences of the United States of America.
NewsMakers
Study links coffee consumption to metabolic health and sex hormones
Despite having a similar body mass index (BMI), individuals with higher coffee consumption had lower total and visceral fat and greater skeletal muscle mass than those who consumed less coffee.
Coffee is one of the world’s most widely consumed beverages, and previous research has linked its consumption to a lower risk of conditions such as type 2 diabetes and cardiovascular disease. However, the biological mechanisms behind these benefits remain unclear. A new Finnish study links habitual coffee consumption to healthier body composition and metabolic markers, while revealing distinct associations with sex hormones in men and women.
The study, conducted at the University of Oulu, analysed data from 2,264 participants aged 46 in the Northern Finland Birth Cohort 1966. Researchers examined how habitual coffee consumption was associated with circulating metabolites, cardiometabolic risk markers and sex hormones.
Despite having a similar body mass index (BMI), individuals with higher coffee consumption had lower total and visceral fat and greater skeletal muscle mass than those who consumed less coffee.
In both men and women, higher coffee consumption was correlated with lower circulating levels of branched-chain amino acids, biomarkers that have previously been linked to insulin resistance and an increased risk of type 2 diabetes when chronically elevated.
The strongest sex-specific associations were observed in men. Higher coffee consumption was linked to a more favourable glucose–insulin profile, higher concentrations of total and bioavailable testosterone, and increased levels of sex hormone-binding globulin (SHBG). At the same time, free testosterone and the free androgen index were modestly lower. In women, hormonal associations were more limited and were primarily characterised by higher SHBG and lower measures of free androgens.
“Coffee is consumed by millions of people every day, yet we still know surprisingly little about how it relates to our metabolism and hormones. What stood out in our findings was a distinct hormonal signature that didn’t disappear even after we took into account BMI and lifestyle factors, with several of these associations differing between men and women,” says Luca Verroest, lead author of the study and Doctoral Researcher at the University of Oulu.
The results suggest that hormonal pathways may partly explain the relationship between coffee consumption and metabolic health. However, as this was an observational study, the findings demonstrate associations rather than cause-and-effect relationships.
The study is particularly relevant in Finland, one of the world’s highest coffee-consuming countries, where annual consumption averages around 11.8 kilograms per person.
The researchers say the findings provide a foundation for future studies aimed at determining whether coffee itself drives these biological changes and identifying the compounds responsible. These questions are currently being investigated in animal models, with the long-term goal of progressing to human intervention studies. Further research will be needed before the findings could inform dietary recommendations.
The study, Associations of habitual coffee intake with testosterone and cardiometabolic markers: the Northern Finland Birth Cohort 1966 study, has been published in the European Journal of Nutrition.
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