NewsMakers
Breastfeeding protects against type 1 diabetes but cow’s milk raises risk, research suggests
Babies that were breastfed for longer and those that were breastfed exclusively were less likely to develop T1D.
New research presented at the Annual Meeting of the European Association for the Study of Diabetes (EASD), held online this year, shows that breastfeeding is associated with a lower risk of developing type 1 diabetes (T1D). Drinking more than two or three glasses of cow’s milk a day in childhood, however, is linked with higher odds of developing T1D.
In T1D, the immune system attacks and destroys the insulin-producing cells in the pancreas. This prevents the body from producing enough of the hormone to properly regulate blood sugar levels.
What triggers the immune system’s attack is unknown but is thought to involve a combination of a genetic predisposition and an environmental trigger such as a virus or foodstuff. In some cases, the condition may develop in people without a genetic predisposition.
Incidence of T1D, the most common form of diabetes in children, is increasing worldwide. The number of diagnoses in young people is rising by an estimated 3.4% annually in Europe and 1.9% in the U.S.
“Type 1 diabetes is a serious condition that requires lifelong treatment,” says Ms Anna-Maria Lampousi of Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, who led the research. “Over time, high blood sugar levels can damage the heart, eyes, feet and kidneys and can shorten life expectancy.
“Learning more about the causes is key to preventing the type 1 diabetes – and its complications.
“The identification of foodstuffs and other environmental triggers which can be modified would be particularly valuable.”
Numerous foodstuffs have been linked to islet autoimmunity – the attack on the insulin-producing cells – and T1D but none of the associations have been firmly established and the existence of a link remains controversial.
In the first study of its kind, Ms Lampousi and colleagues at the Karolinska Institutet carried out a systematic review and meta-analysis of the existing research to identify which foods have been consistently linked to T1D.
The Medline, Embase and Cochrane Library databases were searched from formation until October 2020, for studies on diet, T1D and islet autoimmunity.
Of the 5,935 studies identified, 152 were eligible for inclusion. The analysis produced estimates for how much 27 dietary components increased or reduced the risk of developing T1D. This included foods eaten by the mother in pregnancy and foods consumed in infancy and childhood, as well as being breastfed.
Babies that were breastfed for longer and those that were breastfed exclusively were less likely to develop T1D.
Those breastfed for at least 6-12 months were less than half as likely (61% less likely) to develop T1D than those breastfed for less. Those given only breast milk for the first 2-3 months were 31% less likely to develop the condition than those who weren’t exclusively breastfed.
The researchers say that breastfeeding promotes the maturation of baby’s immune system. Plus, breast milk enhances the baby’s gut microbiota – the bacteria, fungi and other microorganisms that live in the digestive tract and help regulate the immune system.
Higher consumption of cow’s milk and dairy products such as butter, cheese, yoghurt and ice-cream during childhood (under 15 years old) was associated with a higher risk of islet autoimmunity and T1D.
For example, those who drank at least two to three glasses of cow’s milk (one glass = around 200ml) a day were 78% more likely to be develop T1D than those who consumed less than this amount of milk.
It isn’t known what is behind the association but some research has suggested that amino acids (the building blocks of proteins) in cow’s milk can trigger the immune system’s attack on the insulin-producing cells of the pancreas.
Early introduction of cow’s milk to the diet was also associated with a higher risk of T1D. Those who started drinking cow’s milk at two or three months old were 31% less likely to develop T1D than those who started consuming it earlier.
Later introduction of gluten to the diet more than halved the odds of developing T1D. Infants who started eating gluten-containing foods, such as cereal, bread, pastries, biscuits and pasta, at 3-6 months old were 54% less likely to develop T1D than those introduced to the foods earlier.
Waiting until a child was four to six months old to introduce fruit to their diet was associated with a 53% reduction in their likelihood of developing T1D.
The study’s authors say it isn’t clear if delaying introduction to these foods directly protects against T1D or if the infants are benefiting from being breastfed for longer.
Age at introduction to formula milk, meat and vegetables was not linked to risk of T1D. Nor were there any associations between a mother’s intake of gluten and vitamin D in pregnancy and her child’s odds of the condition.
Ms Lampousi concludes: “Diet in infancy and childhood may influence the risk of type 1 diabetes. The strongest findings were for the beneficial effects of breastfeeding and the harmful effects of early introduction to cow’s milk, gluten and fruit.
“However, most of the evidence to-date is of limited quality and further high-quality research is necessary before any specific dietary recommendations can be made.”
NewsMakers
The look and feel of your neighborhood may affect your sleep
Those living in neighborhoods rated as having a stronger sense of safety tended to sleep longer, and that this rating appeared to be shaped by the streetscape.
Your neighborhood’s “streetscape”—the physical environment of your street—is something that you have probably never consciously thought about, despite seeing it every day. But what if the streetscape was affecting you on a subconscious level and disrupting your sleep?
This intriguing question is posed by the findings of a study led by Professor Daisuke Matsushita of the Graduate School of Human Life and Ecology at Osaka Metropolitan University. The research team used AI to analyze more than 200,000 Google Street View images to identify visual neighborhood characteristics. They then linked these characteristics to the self-reported sleep of 1,089 working adults living on the lower floors of apartments in Tokyo, who were most likely to be affected by the streetscape.
They found that those living in neighborhoods rated as having a stronger sense of safety tended to sleep longer, and that this rating appeared to be shaped by the streetscape. Generally, people slept longer in areas with lots of greenery, such as leafy trees, on the street. Similarly, high “enclosure”—meaning many tall vertical buildings and few wide-open spaces—was also associated with longer sleep and fewer insomnia symptoms.
However, the study also made a surprising finding. The researchers found that highly walkable streetscapes, such as those with more sidewalks and traffic signs, were associated with a lowered sense of safety and shortened sleep duration.
This suggests that walkability does not always represent a reassuring environment. Instead, a possible explanation is that streets with extensive pedestrian infrastructure are often busier, more crowded, and used by more strangers, which may be perceived as less safe or less relaxing than quieter residential streets.
“This study demonstrates the potential for evaluating streetscape characteristics across large geographic areas in a cost-effective manner,” Dr. Matsushita said. “Based on the technique used in this study, cities could potentially measure perceived safety, beauty, liveliness, and enclosure as well as pollution and noise.”
“We hope that opening up this new perspective creates further possibilities for designing healthier neighborhoods,” he concludes.
The findings were published in Building and Environment.
NewsMakers
Workout or nap? Either can help your sleepless brain, study finds
People who either completed 20 minutes of moderate-to-vigorous exercise or took a 90-minute nap performed about 22 per cent better on memory tests after 30 hours without sleep than those who did neither.
A short workout or a nap can help protect memory after a sleepless night, a McGill University-led study has found.
Researchers found people who either completed 20 minutes of moderate-to-vigorous exercise or took a 90-minute nap performed about 22 per cent better on memory tests after 30 hours without sleep than those who did neither. The findings, published in Proceedings of the National Academy of Sciences (PNAS), point to practical ways to counter the effects of sleep deprivation.
“Sleep loss affects nearly every aspect of how we think and function, but many people can’t simply stop what they’re doing and get more sleep,” said senior author Marc Roig, Professor in McGill’s School of Physical and Occupational Therapy. “Our findings show that even a brief bout of exercise may help preserve one of our most important cognitive abilities.”
The study involved 54 healthy young adults who stayed awake for 30 consecutive hours under lab supervision. Participants were then assigned to one of three groups: a 20-minute cycling session, a 90-minute nap or a control condition. Three days later, researchers tested their memory for images they had viewed immediately after the intervention. Those who exercised or napped remembered significantly more images than participants who did neither.
Same result, different pathways
While the memory benefits were nearly identical, brain recordings revealed that exercise and napping helped in different ways.
Napping appeared to help the brain recharge, making it easier to take in and remember new information. Exercise, by contrast, helped the brain use its remaining resources more efficiently, without making participants feel more tired.
The findings could eventually inform fatigue-management strategies in workplaces where sleep loss is common and mistakes can have serious consequences, such as health care, transportation and emergency response.
“A nap isn’t always possible in the middle of a shift,” said first author Madhura Lotlikar, a doctoral candidate in McGill’s Department of Neurology and Neurosurgery. “Exercise is accessible, inexpensive and easy to implement. That makes it a promising tool to help people stay cognitively sharp when sleep is limited.”
The researchers emphasize that exercise cannot replace sleep, but it may help people function better when getting enough rest isn’t possible.
About the study
“Protecting episodic memory after sleep loss: Similar benefits of exercise and naps via distinct neural contributions” by Madhura Lotlikar and Marc Roig et al., was published in Proceedings of the National Academy of Sciences of the United States of America.
NewsMakers
Study links coffee consumption to metabolic health and sex hormones
Despite having a similar body mass index (BMI), individuals with higher coffee consumption had lower total and visceral fat and greater skeletal muscle mass than those who consumed less coffee.
Coffee is one of the world’s most widely consumed beverages, and previous research has linked its consumption to a lower risk of conditions such as type 2 diabetes and cardiovascular disease. However, the biological mechanisms behind these benefits remain unclear. A new Finnish study links habitual coffee consumption to healthier body composition and metabolic markers, while revealing distinct associations with sex hormones in men and women.
The study, conducted at the University of Oulu, analysed data from 2,264 participants aged 46 in the Northern Finland Birth Cohort 1966. Researchers examined how habitual coffee consumption was associated with circulating metabolites, cardiometabolic risk markers and sex hormones.
Despite having a similar body mass index (BMI), individuals with higher coffee consumption had lower total and visceral fat and greater skeletal muscle mass than those who consumed less coffee.
In both men and women, higher coffee consumption was correlated with lower circulating levels of branched-chain amino acids, biomarkers that have previously been linked to insulin resistance and an increased risk of type 2 diabetes when chronically elevated.
The strongest sex-specific associations were observed in men. Higher coffee consumption was linked to a more favourable glucose–insulin profile, higher concentrations of total and bioavailable testosterone, and increased levels of sex hormone-binding globulin (SHBG). At the same time, free testosterone and the free androgen index were modestly lower. In women, hormonal associations were more limited and were primarily characterised by higher SHBG and lower measures of free androgens.
“Coffee is consumed by millions of people every day, yet we still know surprisingly little about how it relates to our metabolism and hormones. What stood out in our findings was a distinct hormonal signature that didn’t disappear even after we took into account BMI and lifestyle factors, with several of these associations differing between men and women,” says Luca Verroest, lead author of the study and Doctoral Researcher at the University of Oulu.
The results suggest that hormonal pathways may partly explain the relationship between coffee consumption and metabolic health. However, as this was an observational study, the findings demonstrate associations rather than cause-and-effect relationships.
The study is particularly relevant in Finland, one of the world’s highest coffee-consuming countries, where annual consumption averages around 11.8 kilograms per person.
The researchers say the findings provide a foundation for future studies aimed at determining whether coffee itself drives these biological changes and identifying the compounds responsible. These questions are currently being investigated in animal models, with the long-term goal of progressing to human intervention studies. Further research will be needed before the findings could inform dietary recommendations.
The study, Associations of habitual coffee intake with testosterone and cardiometabolic markers: the Northern Finland Birth Cohort 1966 study, has been published in the European Journal of Nutrition.
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