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E-cigarettes may be independently linked to erectile dysfunction, new research finds

Men between 20 and 65 years of age with no prior history of CVD but who use ENDS daily are more than twice (2.4 times) as likely as men who have never used ENDS to report erectile dysfunction.

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Smoking has long been associated with Erectile Dysfunction (ED) and Cardiovascular Disease (CVD). However, little research has explored if there is a similar association among men who use Electronic Nicotine Delivery Systems (ENDS), commonly referred to as e-cigarettes. In the first population-based study of its kind, researchers from NYU Grossman School of Medicine and Johns Hopkins University School of Medicine published a study online today in the American Journal of Preventive Medicine that suggests men between 20 and 65 years of age with no prior history of CVD but who use ENDS daily are more than twice (2.4 times) as likely as men who have never used ENDS to report erectile dysfunction.   

According to the researchers, since ENDS use seems to be associated with ED independent of age, CVD and other common ED risk factors, ENDS users should be informed about the possible link between ENDS use and experiencing ED—which impacts one in five men over the age of 20 in the United States.

“Given that many people use e-cigarettes as a form of smoking harm reduction or to help them with smoking cessation, we need to fully investigate the relationship between vaping products and erectile dysfunction, and potential implications for men’s sexual health. Our findings underscore the need to conduct further studies to contextualize the e-cigarette use pattern that is relatively safer than smoking,” said Omar El Shahawy, MD, PhD, MPH, assistant professor in the Department of Population Health at NYU Langone and lead author of the study. “Our analyses accounted for the cigarette smoking history of participants, including those who were never cigarette smokers to begin with, so it is possible that daily e-cigarette vaping may be associated with higher odds of erectile dysfunction regardless of one’s smoking history.”

The research team used data from the Population Assessment of Tobacco and Health (PATH) Study, a nationally representative study of 45,971 U.S. adults aged 18 years and older that examines various tobacco use behaviors and health outcomes.

This study was restricted to 13,711 males, 20 years and older, who responded to a question regarding ED. Dr. Tanmik Shah, NYU Langone, the lead statistician and study co-author, examined the association between ENDS and ED in the full sample, as well as in a restricted sample of 11,207 adult males aged 20 to 65 years with no prior CVD diagnosis, while adjusting for multiple risk factors. Respondents were classified as never, former and current (occasional or daily) users. Almost half of the participants were former cigarette smokers, 21 percent were current cigarette smokers, and 14 percent used other tobacco products.

Compared to those who never used ENDS, daily users were more than two times more likely to report having ED (2.2 times in the full sample and 2.4 times in the restricted sample). There was a significant association between ENDS use and ED among respondents aged 20 to 65 with normal Body Mass Index and without CVD, suggesting an association of ED with ENDS use among a relatively healthy population.

Within the restricted sample, 10.2 percent of respondents reported ED. Five and a half percent reported occasional ENDS use while 2.5 percent reported daily ENDS use. Compared to those who reported never using ENDS, current daily ENDS users were more likely to report ED in both the full and restricted samples. Physical activity was associated with lower odds of ED in both population samples.

In addition to El Shahawy, other NYU Langone researchers include Scott Sherman, MD; Tanmik Shah, MPH; Meghan Durr, MPH; Ria Pinjani, MPH. Researchers from the Johns Hopkins School of Medicine include Michael J. Blaha, MD, who is the senior author of this work; Olufunmilayo H. Obisesan, MD, MPH; Albert D. Osei, MD, MPH; Iftekhar Uddin, MD, MSPH and Mohammadhassan Mirbolouk, MD. Additional investigators include Emilia J. Benjamin, MD, Boston University School of Medicine; Andrew Stokes, PhD, Boston University School of Medicine, Tom Loney, PhD, Mohammed Bin Rashid University of Medicine and Health Sciences, UAE.

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Alsons Dev welcomes The Abba’s Orchard to Avia Estate

The country’s largest and most esteemed network of authentic Montessori schools, The Abba’s Orchard, breaks ground on June 14 for its 15th campus located in Avia Estate, a township project in Alabel, Sarangani by Alsons Development and Investment Corporation (Alsons Dev).

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The country’s largest and most esteemed network of authentic Montessori schools, The Abba’s Orchard, breaks ground on June 14 for its 15th campus located in Avia Estate, a township project in Alabel, Sarangani by Alsons Development and Investment Corporation (Alsons Dev).

The expansion reflects the school’s mission of “Discover True Montessori Philippines,” offering high-quality education in the SOCCSKSARGEN Region—a mission that aligns with Alsons Dev’s vision to offer vibrant live-work-play-learn communities where families and businesses can thrive. Recognizing this shared purpose, Alsons Dev partnered with The Abba’s Orchard, contributing a substantial two hectares of land within Avia Estate to make the school a reality.

“We at Alsons Dev are thrilled to partner with The Abba’s Orchard in bringing this exceptional learning environment to Alabel,” said Miguel Dominguez, Alsons Dev Director. “This collaboration aligns with our commitment to fostering growth and development within SOCCSKSARGEN.”

Discover how Avia Estate can let you live your best life. For more information about Avia Estate, visit facebook.com/AviaEstate.

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Optimism wards off procrastination

While procrastinators often admonish themselves for their “bad habit,” it turns out that their worries for the future are more to blame.

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People with an optimistic outlook on the future are less likely to be severe procrastinators, according to new research at the University of Tokyo. While procrastinators often admonish themselves for their “bad habit,” it turns out that their worries for the future are more to blame. Through a survey of nearly 300 young people, researchers found that those who had a positive view about their stress levels decreasing in the future, compared to the past or present, were less likely to experience severe procrastination. Views on personal well-being didn’t appear to have an effect. Improving people’s outlook and readiness for the future could help them overcome procrastination and achieve a less stressful lifestyle. 

How many times have you made a “to do” list, and although the most important task is at the top, you seem to be working your way up from the bottom or distracted by something else entirely? While we might chide ourselves for procrastinating, sometimes the more we try to overcome it, the more stressed we feel and the cycle continues. That is how it was for graduate student Saya Kashiwakura from the Graduate School of Arts and Sciences at the University of Tokyo, so she decided to investigate why.

“I have struggled with procrastination since childhood. I would clean my room when I needed to study for a test and prioritize aikido practice over my postgraduate research. This habit of putting off important tasks has been a constant challenge,” said Kashiwakura. “I wanted to change my behavior, as I realized that I was not confronting the future impact of my actions.”

This inspired Kashiwakura to examine the relationship between procrastination and the procrastinator’s perspective on time, particularly their view of the future. When she began researching procrastination, she was surprised to discover that many more people suffer from it than she had imagined and found it reassuring her problems were not unique.

Previous research has shown that a feature of procrastination is disregard for the future or difficulty linking present actions with future outcomes. However, the reasons for this have been unclear. Kashiwakura and co-author Professor Kazuo Hiraki, also from UTokyo, proposed that it might be because severe procrastinators have a more pessimistic outlook. 

The researchers surveyed 296 participants in Japan in their 20s for their views on stress and well-being, and importantly how these changed over time. This included asking about their experiences from 10 years in the past through to the present, and their expectations for 10 years in the future. From the results, participants were clustered into one of four groups (for example, if they thought their situation would improve or would stay the same), and then each group was divided into severe, middle and low procrastinators. 

“Our research showed that optimistic people — those who believe that stress does not increase as we move into the future — are less likely to have severe procrastination habits,” explained Kashiwakura. “This finding helped me adopt a more light-hearted perspective on the future, leading to a more direct view and reduced procrastination.” 

It was not only the level of stress people experienced, but how their perception of it changed over the 20-year time period discussed, which influenced their procrastination habits. Surprisingly, a relationship wasn’t found between procrastination and negative views on well-being, such as one’s attitude towards oneself, or not yet finding purpose and goals in life.

Using these results, the team wants to develop ways to help people nurture a more optimistic mindset and overcome procrastination. “We hope our findings will be particularly useful in the education sector. We believe that students will achieve better outcomes and experience greater well-being when they can comprehend their procrastination tendencies scientifically, and actively work on improving them, rather than blaming themselves,” said Kashiwakura. 

“Thoughts can change with just a few minutes of watching a video or be shaped by years of accumulation. Our next step is to investigate which approach is appropriate this time, and how we can develop the ‘right’ mindset to lead a happier and more fulfilling life.”

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Study shows how night shift work can raise risk of diabetes, obesity

“When internal rhythms are dysregulated, you have this enduring stress in your system that we believe has long-term health consequences.”

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Just a few days on a night shift schedule throws off protein rhythms related to blood glucose regulation, energy metabolism and inflammation, processes that can influence the development of chronic metabolic conditions.

The finding, from a study led by scientists at Washington State University and the Pacific Northwest National Laboratory, provides new clues as to why night shift workers are more prone to diabetes, obesity and other metabolic disorders.

“There are processes tied to the master biological clock in our brain that are saying that day is day and night is night and other processes that follow rhythms set elsewhere in the body that say night is day and day is night,” said senior study author Hans Van Dongen, a professor in the WSU Elson S. Floyd College of Medicine. “When internal rhythms are dysregulated, you have this enduring stress in your system that we believe has long-term health consequences.”

Though more research is needed, Van Dongen said the study shows that these disrupted rhythms can be seen in as little as three days, which suggests early intervention to prevent diabetes and obesity is possible. Such intervention could also help lower the risk of heart disease and stroke, which is elevated in night shift workers as well.

Published in the Journal of Proteome Research, the study involved a controlled laboratory experiment with volunteers who were put on simulated night or day shift schedules for three days. Following their last shift, participants were kept awake for 24 hours under constant conditions—lighting, temperature, posture and food intake—to measure their internal biological rhythms without interference from outside influences. 

Blood samples drawn at regular intervals throughout the 24-hour period were analyzed to identify proteins present in blood-based immune system cells. Some proteins had rhythms closely tied to the master biological clock, which keeps the body on a 24-hour rhythm. The master clock is resilient to altered shift schedules, so these protein rhythms didn’t change much in response to the night shift schedule.

However, most other proteins had rhythms that changed substantially in night shift participants compared to the day shift participants.

Looking more closely at proteins involved in glucose regulation, the researchers observed a nearly complete reversal of glucose rhythms in night shift participants. They also found that processes involved in insulin production and sensitivity, which normally work together to keep glucose levels within a healthy range, were no longer synchronized in night shift participants.

The researchers said this effect could be caused by the regulation of insulin trying to undo the glucose changes triggered by the night shift schedule. They said this may be a healthy response in the moment, as altered glucose levels may damage cells and organs, but could be problematic in the long run.

“What we showed is that we can really see a difference in molecular patterns between volunteers with normal schedules and those with schedules that are misaligned with their biological clock,” said Jason McDermott, a computational scientist with PNNL’s Biological Sciences Division. “The effects of this misalignment had not yet been characterized at this molecular level and in this controlled manner before.”

The researchers’ next step will be to study real-world workers to determine whether night shifts cause similar protein changes in long-term shift workers.

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