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What causes cervical cancer and how you can prevent it

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Every year, more than 500,000 women are diagnosed with cervical cancer. In the Philippines, it is the second most common cancer among Filipino women aged 15 to 44 years old, with seven dying of the dreaded disease every single day.

At a press event organized by GSK Philippines, Esther Ganzon, Head of the Gynecologic Oncology Dept., Paranaque Doctors Hospital, says that cervical cancer occurs when abnormal cells develop and spread in the cervix, the entrance between the vagina and the uterus.

Ganzon notes that the incidence of cervical cancer starts rising steeply at age 30. It is highest in women ages 40 to 55 years old. “My youngest patient was a 11-year old girl who was sold as a sex worker since she was 5 years old by her mother,” revealed Ganzon.

So what causes cervical cancer?

Ganzon says that persistent infection with the human papillomavirus (HPV), a very common virus, is the necessary cause of cervical cancer. It has been shown that 99.7 percent of cervical cancer patients are positive for HPV infection.  It is also estimated that up to 80 percent of women will be infected with HPV at some point in their lives.

There are more than 100 types of HPV, of which at least 13 are cancer-causing. Worldwide, HPV 16 and 18 contribute to 70% of all cancer cases, according to Ganzon.

The risk of developing cervical cancer is 250 to 400 times higher following persistent infection with oncogenic types compared to uninfected women.

The risk factors for HPV persistence and development of cervical cancer include tobacco smoking, early first sexual intercourse, multiple sexual partners, high parity, long-term  use of oral contraceptive pills, and co-infection with HPV.

Ganzon says that while HPV is primarily transmitted via sexual intercourse, skin-to-skin genital contact is also a recognized mode of transmission.

What are the symptoms?

Ganzon warns that in its early stage (stages 1 and 2), cervical cancer may have no signs or symptoms. Symptoms only appear after the cancer has reached an advanced stage and may include:

– Irregular, intermenstrual (between periods) or abnormal vaginal bleeding after sexual intercourse
– back, leg or pelvic pain
– fatigue, weight loss, loss of appetite
– vaginal discomfort or odourous discharge
– a single swollen leg

More symptoms may arise at advanced stages.

How do you prevent it?

Sexual behavior can help prevent the development of cervical cancer, such as being conscientious about one’s sexual activities.

Beyond changing sexual behaviour, the disease can be prevented as early as 9 years of age through HPV vaccination, a primary prevention tool, says Ganzon. The World Health Organization recommends that routine HPV vaccination should be included in national immunization programs.

Secondary prevention includes screening which includes pap smear and HPV DNA test. Ganzon says that in low-resource settings, visual inspection with acetic acid is used to identify cervical lesions, which can be immediately treated by cyrotherapy.

Ganzon stressed that HPV vaccines are designed for prophylactic use only and does not eliminate screening later in life. She also emphasized that HPV vaccines do not clear existing HPV infection or treat HPV-related diseases.

HPV vaccines are “generally safe and effective,” claims Ganzon, adding that the most common reaction observed after vaccine administration was injection site pain. 

Driving awareness

To ramp up its cervical cancer awareness efforts, GSK Philippines has launched the Power Over Cervical Cancer campaign which urges Filipinas to realize that they can do something to prevent the disease from happening to them.

To spread the awareness, GSK Philippines launched its partnership with cosmetics manufacturer VMV Hypoallergenics at a press event entitled “Put On Your Power Pout!”

The partnership introduces a twist on spreading awareness: encouraging women to join the movement by wearing purple lipstick to show their support for the advocacy on cervical cancer prevention.

“Cancer is quite a distant concept for women who are well. What might be more important to them is keeping up with the latest trends, especially in fashion and beauty. The lipstick is a woman’s own—when she wears it, she makes a statement about herself. Through this partnership with VMV, we hope to drive women to make a statement against cervical cancer,” says Mark Castillo, GSK product manager.


This article neither serves as a public health advisory nor endorses a product. Always consult your doctor before taking any treatment for any medical condition.

MELBA V. BERNAD started her career as an IT journalist with Computerworld Philippines which she joined in December 1993. She was Editor of the publication when she left in March 2013. Melba is currently Manila-based Editor of Networks Asia (Singapore), SMBWorld Asia (Singapore), and CFO Innovation Asia (Hong Kong). She is a two-time awardee of the Catholic Mass Media Awards (Best News Coverage in 2003 and Best News Coverage (Print) in 2004). She was also an awardee of the first Philippine Cyberpress Journalism Award. Melba is a co-publisher and concurrent Editor in Chief of Zest Magazine.

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The look and feel of your neighborhood may affect your sleep

Those living in neighborhoods rated as having a stronger sense of safety tended to sleep longer, and that this rating appeared to be shaped by the streetscape.

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Your neighborhood’s “streetscape”—the physical environment of your street—is something that you have probably never consciously thought about, despite seeing it every day. But what if the streetscape was affecting you on a subconscious level and disrupting your sleep? 

This intriguing question is posed by the findings of a study led by Professor Daisuke Matsushita of the Graduate School of Human Life and Ecology at Osaka Metropolitan University. The research team used AI to analyze more than 200,000 Google Street View images to identify visual neighborhood characteristics. They then linked these characteristics to the self-reported sleep of 1,089 working adults living on the lower floors of apartments in Tokyo, who were most likely to be affected by the streetscape.  

They found that those living in neighborhoods rated as having a stronger sense of safety tended to sleep longer, and that this rating appeared to be shaped by the streetscape. Generally, people slept longer in areas with lots of greenery, such as leafy trees, on the street. Similarly, high “enclosure”—meaning many tall vertical buildings and few wide-open spaces—was also associated with longer sleep and fewer insomnia symptoms. 

However, the study also made a surprising finding. The researchers found that highly walkable streetscapes, such as those with more sidewalks and traffic signs, were associated with a lowered sense of safety and shortened sleep duration.  

This suggests that walkability does not always represent a reassuring environment. Instead, a possible explanation is that streets with extensive pedestrian infrastructure are often busier, more crowded, and used by more strangers, which may be perceived as less safe or less relaxing than quieter residential streets.  

“This study demonstrates the potential for evaluating streetscape characteristics across large geographic areas in a cost-effective manner,” Dr. Matsushita said. “Based on the technique used in this study, cities could potentially measure perceived safety, beauty, liveliness, and enclosure as well as pollution and noise.”  

“We hope that opening up this new perspective creates further possibilities for designing healthier neighborhoods,” he concludes.  

The findings were published in Building and Environment.

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Workout or nap? Either can help your sleepless brain, study finds

People who either completed 20 minutes of moderate-to-vigorous exercise or took a 90-minute nap performed about 22 per cent better on memory tests after 30 hours without sleep than those who did neither.

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A short workout or a nap can help protect memory after a sleepless night, a McGill University-led study has found.

Researchers found people who either completed 20 minutes of moderate-to-vigorous exercise or took a 90-minute nap performed about 22 per cent better on memory tests after 30 hours without sleep than those who did neither. The findings, published in Proceedings of the National Academy of Sciences (PNAS), point to practical ways to counter the effects of sleep deprivation.

“Sleep loss affects nearly every aspect of how we think and function, but many people can’t simply stop what they’re doing and get more sleep,” said senior author Marc Roig, Professor in McGill’s School of Physical and Occupational Therapy. “Our findings show that even a brief bout of exercise may help preserve one of our most important cognitive abilities.”

The study involved 54 healthy young adults who stayed awake for 30 consecutive hours under lab supervision. Participants were then assigned to one of three groups: a 20-minute cycling session, a 90-minute nap or a control condition. Three days later, researchers tested their memory for images they had viewed immediately after the intervention. Those who exercised or napped remembered significantly more images than participants who did neither.

Same result, different pathways

While the memory benefits were nearly identical, brain recordings revealed that exercise and napping helped in different ways.

Napping appeared to help the brain recharge, making it easier to take in and remember new information. Exercise, by contrast, helped the brain use its remaining resources more efficiently, without making participants feel more tired.

The findings could eventually inform fatigue-management strategies in workplaces where sleep loss is common and mistakes can have serious consequences, such as health care, transportation and emergency response.

“A nap isn’t always possible in the middle of a shift,” said first author Madhura Lotlikar, a doctoral candidate in McGill’s Department of Neurology and Neurosurgery. “Exercise is accessible, inexpensive and easy to implement. That makes it a promising tool to help people stay cognitively sharp when sleep is limited.”

The researchers emphasize that exercise cannot replace sleep, but it may help people function better when getting enough rest isn’t possible.

About the study

Protecting episodic memory after sleep loss: Similar benefits of exercise and naps via distinct neural contributions” by Madhura Lotlikar and Marc Roig et al., was published in Proceedings of the National Academy of Sciences of the United States of America.

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Study links coffee consumption to metabolic health and sex hormones

Despite having a similar body mass index (BMI), individuals with higher coffee consumption had lower total and visceral fat and greater skeletal muscle mass than those who consumed less coffee.

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Coffee is one of the world’s most widely consumed beverages, and previous research has linked its consumption to a lower risk of conditions such as type 2 diabetes and cardiovascular disease. However, the biological mechanisms behind these benefits remain unclear. A new Finnish study links habitual coffee consumption to healthier body composition and metabolic markers, while revealing distinct associations with sex hormones in men and women.

The study, conducted at the University of Oulu, analysed data from 2,264 participants aged 46 in the Northern Finland Birth Cohort 1966. Researchers examined how habitual coffee consumption was associated with circulating metabolites, cardiometabolic risk markers and sex hormones.

Despite having a similar body mass index (BMI), individuals with higher coffee consumption had lower total and visceral fat and greater skeletal muscle mass than those who consumed less coffee.

In both men and women, higher coffee consumption was correlated with lower circulating levels of branched-chain amino acids, biomarkers that have previously been linked to insulin resistance and an increased risk of type 2 diabetes when chronically elevated.

The strongest sex-specific associations were observed in men. Higher coffee consumption was linked to a more favourable glucose–insulin profile, higher concentrations of total and bioavailable testosterone, and increased levels of sex hormone-binding globulin (SHBG). At the same time, free testosterone and the free androgen index were modestly lower. In women, hormonal associations were more limited and were primarily characterised by higher SHBG and lower measures of free androgens.

“Coffee is consumed by millions of people every day, yet we still know surprisingly little about how it relates to our metabolism and hormones. What stood out in our findings was a distinct hormonal signature that didn’t disappear even after we took into account BMI and lifestyle factors, with several of these associations differing between men and women,” says Luca Verroest, lead author of the study and Doctoral Researcher at the University of Oulu.

The results suggest that hormonal pathways may partly explain the relationship between coffee consumption and metabolic health. However, as this was an observational study, the findings demonstrate associations rather than cause-and-effect relationships.

The study is particularly relevant in Finland, one of the world’s highest coffee-consuming countries, where annual consumption averages around 11.8 kilograms per person.

The researchers say the findings provide a foundation for future studies aimed at determining whether coffee itself drives these biological changes and identifying the compounds responsible. These questions are currently being investigated in animal models, with the long-term goal of progressing to human intervention studies. Further research will be needed before the findings could inform dietary recommendations.

The study, Associations of habitual coffee intake with testosterone and cardiometabolic markers: the Northern Finland Birth Cohort 1966 study, has been published in the European Journal of Nutrition.

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