NewsMakers
Hearing loss linked to heightened heart failure risk
Both the participants who used hearing aids and those with poor hearing had a similarly significant increase in the risk of incident [heart failure], suggesting that while hearing aids can improve auditory function, they may not address the underlying vascular issues that contribute to the risk of [heart failure].
Hearing loss is linked to a heightened risk of developing heart failure, with the psychological distress caused by the impairment taking a key role in the observed association, finds a large long term study, published online in the journal Heart.
Hearing loss is increasingly common, particularly as people age, while the prevalence of heart failure is also on the rise, affecting around 64 million people worldwide, note the researchers.
While impaired hearing is associated with an increased risk of cardiovascular disease, principally, it is thought, as a result of the resulting social detachment, no study has comprehensively examined the association between objectively measured hearing ability and the risk of developing heart failure.
In a bid to plug this knowledge gap, the researchers mined the data of 164,431 participants from the UK Biobank, 4369 of whom wore hearing aids. None had heart failure to begin with. The average age of participants was 56, and 89,818 (around 55%) were women.
Their hearing ability was objectively measured using the validated Digit Triplets Test and the speech-reception-threshold (SRT). Participants (160,062) who didn’t wear hearing aids were categorised into three groups according to their performance on the DTT: normal (140,839; 88%); insufficient (16,759;10.5%); and poor (2464; 1.5%).
Comprehensive background information on current health, lifestyle, and psychosocial factors was collected via questionnaires.
Social isolation was assessed using a composite definition in the UK Biobank derived from scores (1-3) for the number of people living in the household, frequency of friend or family visits, and leisure or social activities. Those with a score of 2 or 3 were classified as socially isolated.
Psychological distress was assessed using a four-item version of the Patient Health Questionnaire (PHQ-4), with a score ranging from 0 to 12. Neuroticism, a depression-related personality trait, was assessed using 12 questions from the Eysenck Personality Questionnaire-Revised Short Form.
The development of heart failure among those who were not genetically predisposed to the condition was identified through medical records and death certificates during an average follow up of 11½ years.
During this period, 4449 (nearly 3%) of the participants developed heart failure. SRT levels were significantly positively associated with the risk of developing the condition in participants who didn’t wear hearing aids.
Compared with those with normal hearing, the adjusted heightened risks of developing heart failure were 15% and 28%, respectively, for insufficient and poor hearing, and 26% for hearing aid use.
The associations between SRT levels and heart failure risk were stronger in those without coronary heart disease or stroke at the start of the study.
SRT levels were significantly positively associated with social isolation, psychological distress, and neuroticism among those who didn’t wear hearing aids. And these factors had a substantial role in the observed associations in participants who didn’t wear hearing aids, accounting for 3%, 17%, and 3%, respectively, of the heightened risk of heart failure development.
When the scores for social isolation, psychological distress, and neuroticism were combined among those who had full data on these factors, the total mediating effect was just over 9%.
This was less than the sum of the mediating effects of each individual factor, which amounted to 19.5%, suggesting overlap and interaction between these three factors, say the researchers.
This is an observational study, and as such, can’t establish cause and effect. And data on hearing were collected only at the start of the study, while the participants in the current study were mainly of European descent and healthier than the UK general population, they acknowledge.
But there are plausible biological explanations for their findings, they say. “The rich distribution of capillaries in the…cochlea and the high metabolic demand of the inner ear may render these regions more sensitive to systemic vascular disorders rather than just local circulatory issues,” they suggest.
“Therefore, hearing impairment may reflect vascular health and serve as an early and sensitive predictor of cardiovascular disease, including [heart failure],” they add.
“Of note, both the participants who used hearing aids and those with poor hearing had a similarly significant increase in the risk of incident [heart failure], suggesting that while hearing aids can improve auditory function, they may not address the underlying vascular issues that contribute to the risk of [heart failure],” they continue.
And they explain: “Because hearing problems can lead to difficulties in speech comprehension and poor engagement in social activities, people with hearing impairment are more likely to experience social isolation, psychological distress, anxiety and depression than people without hearing impairment.
“These psychological factors may increase the activity of the sympathetic nervous system and the hypothalamic-pituitary adrenal axis, and enhance inflammation and oxidative stress, thereby accelerating atherosclerosis, increasing peripheral stress, and promoting the development of cardiac remodelling.”
The findings highlight the importance of integrating hearing health assessments into broader cardiovascular risk evaluation frameworks, they conclude. And strengthening psychological intervention in people with hearing impairment may be key to curbing the risk of heart failure, they suggest.
NewsMakers
The look and feel of your neighborhood may affect your sleep
Those living in neighborhoods rated as having a stronger sense of safety tended to sleep longer, and that this rating appeared to be shaped by the streetscape.
Your neighborhood’s “streetscape”—the physical environment of your street—is something that you have probably never consciously thought about, despite seeing it every day. But what if the streetscape was affecting you on a subconscious level and disrupting your sleep?
This intriguing question is posed by the findings of a study led by Professor Daisuke Matsushita of the Graduate School of Human Life and Ecology at Osaka Metropolitan University. The research team used AI to analyze more than 200,000 Google Street View images to identify visual neighborhood characteristics. They then linked these characteristics to the self-reported sleep of 1,089 working adults living on the lower floors of apartments in Tokyo, who were most likely to be affected by the streetscape.
They found that those living in neighborhoods rated as having a stronger sense of safety tended to sleep longer, and that this rating appeared to be shaped by the streetscape. Generally, people slept longer in areas with lots of greenery, such as leafy trees, on the street. Similarly, high “enclosure”—meaning many tall vertical buildings and few wide-open spaces—was also associated with longer sleep and fewer insomnia symptoms.
However, the study also made a surprising finding. The researchers found that highly walkable streetscapes, such as those with more sidewalks and traffic signs, were associated with a lowered sense of safety and shortened sleep duration.
This suggests that walkability does not always represent a reassuring environment. Instead, a possible explanation is that streets with extensive pedestrian infrastructure are often busier, more crowded, and used by more strangers, which may be perceived as less safe or less relaxing than quieter residential streets.
“This study demonstrates the potential for evaluating streetscape characteristics across large geographic areas in a cost-effective manner,” Dr. Matsushita said. “Based on the technique used in this study, cities could potentially measure perceived safety, beauty, liveliness, and enclosure as well as pollution and noise.”
“We hope that opening up this new perspective creates further possibilities for designing healthier neighborhoods,” he concludes.
The findings were published in Building and Environment.
NewsMakers
Workout or nap? Either can help your sleepless brain, study finds
People who either completed 20 minutes of moderate-to-vigorous exercise or took a 90-minute nap performed about 22 per cent better on memory tests after 30 hours without sleep than those who did neither.
A short workout or a nap can help protect memory after a sleepless night, a McGill University-led study has found.
Researchers found people who either completed 20 minutes of moderate-to-vigorous exercise or took a 90-minute nap performed about 22 per cent better on memory tests after 30 hours without sleep than those who did neither. The findings, published in Proceedings of the National Academy of Sciences (PNAS), point to practical ways to counter the effects of sleep deprivation.
“Sleep loss affects nearly every aspect of how we think and function, but many people can’t simply stop what they’re doing and get more sleep,” said senior author Marc Roig, Professor in McGill’s School of Physical and Occupational Therapy. “Our findings show that even a brief bout of exercise may help preserve one of our most important cognitive abilities.”
The study involved 54 healthy young adults who stayed awake for 30 consecutive hours under lab supervision. Participants were then assigned to one of three groups: a 20-minute cycling session, a 90-minute nap or a control condition. Three days later, researchers tested their memory for images they had viewed immediately after the intervention. Those who exercised or napped remembered significantly more images than participants who did neither.
Same result, different pathways
While the memory benefits were nearly identical, brain recordings revealed that exercise and napping helped in different ways.
Napping appeared to help the brain recharge, making it easier to take in and remember new information. Exercise, by contrast, helped the brain use its remaining resources more efficiently, without making participants feel more tired.
The findings could eventually inform fatigue-management strategies in workplaces where sleep loss is common and mistakes can have serious consequences, such as health care, transportation and emergency response.
“A nap isn’t always possible in the middle of a shift,” said first author Madhura Lotlikar, a doctoral candidate in McGill’s Department of Neurology and Neurosurgery. “Exercise is accessible, inexpensive and easy to implement. That makes it a promising tool to help people stay cognitively sharp when sleep is limited.”
The researchers emphasize that exercise cannot replace sleep, but it may help people function better when getting enough rest isn’t possible.
About the study
“Protecting episodic memory after sleep loss: Similar benefits of exercise and naps via distinct neural contributions” by Madhura Lotlikar and Marc Roig et al., was published in Proceedings of the National Academy of Sciences of the United States of America.
NewsMakers
Study links coffee consumption to metabolic health and sex hormones
Despite having a similar body mass index (BMI), individuals with higher coffee consumption had lower total and visceral fat and greater skeletal muscle mass than those who consumed less coffee.
Coffee is one of the world’s most widely consumed beverages, and previous research has linked its consumption to a lower risk of conditions such as type 2 diabetes and cardiovascular disease. However, the biological mechanisms behind these benefits remain unclear. A new Finnish study links habitual coffee consumption to healthier body composition and metabolic markers, while revealing distinct associations with sex hormones in men and women.
The study, conducted at the University of Oulu, analysed data from 2,264 participants aged 46 in the Northern Finland Birth Cohort 1966. Researchers examined how habitual coffee consumption was associated with circulating metabolites, cardiometabolic risk markers and sex hormones.
Despite having a similar body mass index (BMI), individuals with higher coffee consumption had lower total and visceral fat and greater skeletal muscle mass than those who consumed less coffee.
In both men and women, higher coffee consumption was correlated with lower circulating levels of branched-chain amino acids, biomarkers that have previously been linked to insulin resistance and an increased risk of type 2 diabetes when chronically elevated.
The strongest sex-specific associations were observed in men. Higher coffee consumption was linked to a more favourable glucose–insulin profile, higher concentrations of total and bioavailable testosterone, and increased levels of sex hormone-binding globulin (SHBG). At the same time, free testosterone and the free androgen index were modestly lower. In women, hormonal associations were more limited and were primarily characterised by higher SHBG and lower measures of free androgens.
“Coffee is consumed by millions of people every day, yet we still know surprisingly little about how it relates to our metabolism and hormones. What stood out in our findings was a distinct hormonal signature that didn’t disappear even after we took into account BMI and lifestyle factors, with several of these associations differing between men and women,” says Luca Verroest, lead author of the study and Doctoral Researcher at the University of Oulu.
The results suggest that hormonal pathways may partly explain the relationship between coffee consumption and metabolic health. However, as this was an observational study, the findings demonstrate associations rather than cause-and-effect relationships.
The study is particularly relevant in Finland, one of the world’s highest coffee-consuming countries, where annual consumption averages around 11.8 kilograms per person.
The researchers say the findings provide a foundation for future studies aimed at determining whether coffee itself drives these biological changes and identifying the compounds responsible. These questions are currently being investigated in animal models, with the long-term goal of progressing to human intervention studies. Further research will be needed before the findings could inform dietary recommendations.
The study, Associations of habitual coffee intake with testosterone and cardiometabolic markers: the Northern Finland Birth Cohort 1966 study, has been published in the European Journal of Nutrition.
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