NewsMakers
Dengue vaccine now available at select Watsons stores
Dengvaxia, a vaccine against dengue, is now available over-the-counter nationwide at select stores of Watsons, the first retailer to offer the vaccine in the Philippines.
“We decided to offer dengue vaccination in our 108 selected stores nationwide as we recognize the importance of having vaccination accessible to Filipinos to protect them against dengue infection and make them healthier. It is our latest addition that we offer in our stores, aside from cervical cancer, flu and pneumonia vaccinations,” says Danilo Chiong, Watsons Trading Health Director.
Produced by pharmaceutical firm Sanofi Pasteur, Dengvaxia took over 20 years of extensive research and tests to develop. Studies on the vaccine were conducted on 41,000 people and were carried out in 15 countries including the Philippines. With test results fully reviewed by a committee of independent experts, the vaccine has been recommended by the World Health Organization (WHO).
In a WHO position paper published in July 29, 2016, it says that to prevent dengue infection, dengue vaccine should be a part of a comprehensive dengue control strategy, which include well-executed and sustained vector controls, evidence-based best practices for clinical care and strong dengue surveillance.
The vaccine has also been endorsed by the Philippine Society for Microbiology and infectious Diseases (PSMID) and Philippine College of Physicians (PCP). In February 2017, the vaccine got the approval to be administered in 14 countries, including the Philippines, where dengue is endemic.
In the Philippines, there were 211,106 reported dengue cases in 2016. The most number of cases was reported in Regions VI, VII, III, IV-A, and XII. All age groups were affected by dengue.
Age bracket and dosage
Since there is no specific treatment for dengue, Dr. Rontgene Solante, Past President at PSMID, said the dengue vaccine can protect individuals against the illness. It can be administered to individuals 9 to 45 years old living in endemic areas for prevention of dengue illness caused by dengue virus serotypes 1, 2, 3 and 4. It is to be taken in three doses of 0.5ml at six-month intervals to increase antibodies response, thereby protecting them from all four strains of the virus. The vaccine, when correctly administered in three doses, stays effective in four to five years.
The vaccine costs P4,000 per dose or P12,000 for all three doses, which is reasonable considering the high incidence of dengue and high cost of treatment in the Philippines.
“The vaccine is not just for kids but adults should also be vaccinated as this is safe and can modify infection. Don’t look at the price but in the long-term benefits it provides,” said Solante.
Solante, however, relayed the vaccine is not effective for children below nine years old. A study made on the vaccine and these children showed that the efficacy of the vaccine was below 50%. Likewise, the vaccine cannot be administered to persons over 45 years old as there was no study made yet about its effectiveness for these individuals.
Apart from these, other persons who have the following cannot take the vaccine: history of severe allergic reaction; congenital or acquired immune deficiency diseases; symptomatic HIV infection; and pregnant or breastfeeding women.
Solante, however, said that those were infected by dengue in the past can still avail of the vaccine.
Solante advised individuals to administer the vaccine correctly. “If a person who has taken the first dose fails to take the second dose on the scheduled (sixth) month, and instead take it, let’s say, on the eighth month, the vaccine is still effective. But, if he misses taking it for a couple of years, the vaccine became ineffective and has to start taking it all over again.”
The vaccine is injected in arms via the subcutaneous route over the deltoid region. How is it effective? In his presentation, Dr. Solante said the vaccine can result to 80.8% reduction in hospitalized dengue; 93.2% drop in severe dengue; and 65.6% decline in symptomatic dengue, which means that if a person is infected, symptoms are reduced.
The vaccine does not contain adjuvants or preservatives so the adverse effect or reaction is lower, according to Solante. Adverse reactions include headache, malaise, myalgia, pain, injection site reaction, and other mild to moderate reactions.
A study conducted by the University of the Philippines showed that the vaccine is expected to reduce dengue cases in the country by over 24% in a span of five years.
Meanwhile, Chiong said that they will have a doctor in over 100 selected Watsons stores to administer the vaccine during vaccination dates. The first scheduled dengue vaccination will be on April 30, 2017 (1st dose); October 29, 2017 (2nd dose) and April 29, 2018 (3rd dose). The second schedule vaccination will be on May 14, 2018 (1st dose); November 12, 2018 (2nd dose); and May 13, 2018 (3rd dose).
NewsMakers
The look and feel of your neighborhood may affect your sleep
Those living in neighborhoods rated as having a stronger sense of safety tended to sleep longer, and that this rating appeared to be shaped by the streetscape.
Your neighborhood’s “streetscape”—the physical environment of your street—is something that you have probably never consciously thought about, despite seeing it every day. But what if the streetscape was affecting you on a subconscious level and disrupting your sleep?
This intriguing question is posed by the findings of a study led by Professor Daisuke Matsushita of the Graduate School of Human Life and Ecology at Osaka Metropolitan University. The research team used AI to analyze more than 200,000 Google Street View images to identify visual neighborhood characteristics. They then linked these characteristics to the self-reported sleep of 1,089 working adults living on the lower floors of apartments in Tokyo, who were most likely to be affected by the streetscape.
They found that those living in neighborhoods rated as having a stronger sense of safety tended to sleep longer, and that this rating appeared to be shaped by the streetscape. Generally, people slept longer in areas with lots of greenery, such as leafy trees, on the street. Similarly, high “enclosure”—meaning many tall vertical buildings and few wide-open spaces—was also associated with longer sleep and fewer insomnia symptoms.
However, the study also made a surprising finding. The researchers found that highly walkable streetscapes, such as those with more sidewalks and traffic signs, were associated with a lowered sense of safety and shortened sleep duration.
This suggests that walkability does not always represent a reassuring environment. Instead, a possible explanation is that streets with extensive pedestrian infrastructure are often busier, more crowded, and used by more strangers, which may be perceived as less safe or less relaxing than quieter residential streets.
“This study demonstrates the potential for evaluating streetscape characteristics across large geographic areas in a cost-effective manner,” Dr. Matsushita said. “Based on the technique used in this study, cities could potentially measure perceived safety, beauty, liveliness, and enclosure as well as pollution and noise.”
“We hope that opening up this new perspective creates further possibilities for designing healthier neighborhoods,” he concludes.
The findings were published in Building and Environment.
NewsMakers
Workout or nap? Either can help your sleepless brain, study finds
People who either completed 20 minutes of moderate-to-vigorous exercise or took a 90-minute nap performed about 22 per cent better on memory tests after 30 hours without sleep than those who did neither.
A short workout or a nap can help protect memory after a sleepless night, a McGill University-led study has found.
Researchers found people who either completed 20 minutes of moderate-to-vigorous exercise or took a 90-minute nap performed about 22 per cent better on memory tests after 30 hours without sleep than those who did neither. The findings, published in Proceedings of the National Academy of Sciences (PNAS), point to practical ways to counter the effects of sleep deprivation.
“Sleep loss affects nearly every aspect of how we think and function, but many people can’t simply stop what they’re doing and get more sleep,” said senior author Marc Roig, Professor in McGill’s School of Physical and Occupational Therapy. “Our findings show that even a brief bout of exercise may help preserve one of our most important cognitive abilities.”
The study involved 54 healthy young adults who stayed awake for 30 consecutive hours under lab supervision. Participants were then assigned to one of three groups: a 20-minute cycling session, a 90-minute nap or a control condition. Three days later, researchers tested their memory for images they had viewed immediately after the intervention. Those who exercised or napped remembered significantly more images than participants who did neither.
Same result, different pathways
While the memory benefits were nearly identical, brain recordings revealed that exercise and napping helped in different ways.
Napping appeared to help the brain recharge, making it easier to take in and remember new information. Exercise, by contrast, helped the brain use its remaining resources more efficiently, without making participants feel more tired.
The findings could eventually inform fatigue-management strategies in workplaces where sleep loss is common and mistakes can have serious consequences, such as health care, transportation and emergency response.
“A nap isn’t always possible in the middle of a shift,” said first author Madhura Lotlikar, a doctoral candidate in McGill’s Department of Neurology and Neurosurgery. “Exercise is accessible, inexpensive and easy to implement. That makes it a promising tool to help people stay cognitively sharp when sleep is limited.”
The researchers emphasize that exercise cannot replace sleep, but it may help people function better when getting enough rest isn’t possible.
About the study
“Protecting episodic memory after sleep loss: Similar benefits of exercise and naps via distinct neural contributions” by Madhura Lotlikar and Marc Roig et al., was published in Proceedings of the National Academy of Sciences of the United States of America.
NewsMakers
Study links coffee consumption to metabolic health and sex hormones
Despite having a similar body mass index (BMI), individuals with higher coffee consumption had lower total and visceral fat and greater skeletal muscle mass than those who consumed less coffee.
Coffee is one of the world’s most widely consumed beverages, and previous research has linked its consumption to a lower risk of conditions such as type 2 diabetes and cardiovascular disease. However, the biological mechanisms behind these benefits remain unclear. A new Finnish study links habitual coffee consumption to healthier body composition and metabolic markers, while revealing distinct associations with sex hormones in men and women.
The study, conducted at the University of Oulu, analysed data from 2,264 participants aged 46 in the Northern Finland Birth Cohort 1966. Researchers examined how habitual coffee consumption was associated with circulating metabolites, cardiometabolic risk markers and sex hormones.
Despite having a similar body mass index (BMI), individuals with higher coffee consumption had lower total and visceral fat and greater skeletal muscle mass than those who consumed less coffee.
In both men and women, higher coffee consumption was correlated with lower circulating levels of branched-chain amino acids, biomarkers that have previously been linked to insulin resistance and an increased risk of type 2 diabetes when chronically elevated.
The strongest sex-specific associations were observed in men. Higher coffee consumption was linked to a more favourable glucose–insulin profile, higher concentrations of total and bioavailable testosterone, and increased levels of sex hormone-binding globulin (SHBG). At the same time, free testosterone and the free androgen index were modestly lower. In women, hormonal associations were more limited and were primarily characterised by higher SHBG and lower measures of free androgens.
“Coffee is consumed by millions of people every day, yet we still know surprisingly little about how it relates to our metabolism and hormones. What stood out in our findings was a distinct hormonal signature that didn’t disappear even after we took into account BMI and lifestyle factors, with several of these associations differing between men and women,” says Luca Verroest, lead author of the study and Doctoral Researcher at the University of Oulu.
The results suggest that hormonal pathways may partly explain the relationship between coffee consumption and metabolic health. However, as this was an observational study, the findings demonstrate associations rather than cause-and-effect relationships.
The study is particularly relevant in Finland, one of the world’s highest coffee-consuming countries, where annual consumption averages around 11.8 kilograms per person.
The researchers say the findings provide a foundation for future studies aimed at determining whether coffee itself drives these biological changes and identifying the compounds responsible. These questions are currently being investigated in animal models, with the long-term goal of progressing to human intervention studies. Further research will be needed before the findings could inform dietary recommendations.
The study, Associations of habitual coffee intake with testosterone and cardiometabolic markers: the Northern Finland Birth Cohort 1966 study, has been published in the European Journal of Nutrition.
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