NewsMakers
Bad breath, bad news: How gum disease could worsen liver conditions
Chronic periodontal inflammation leads to the release of pro-inflammatory cytokines like TNF-alpha and IL-6, which have long been implicated in the progression of liver disease.
There is growing recognition in medicine that what happens in one part of the body can ripple through others. That idea is now being explored in a surprising place: the mouth. A new review by an international group of researchers has examined the mounting evidence linking periodontal disease—commonly known as gum disease—to chronic liver conditions, including cirrhosis, metabolic dysfunction-associated steatotic liver disease (MASLD), and alcohol-related liver disease. Though the mouth and liver are separated by both distance and function, the paper makes a compelling case that these two systems are more connected than we thought.
Gum disease, especially in its more advanced form known as periodontitis, is a chronic inflammatory condition caused by bacterial infections in the tissues that support the teeth. It is one of the most common diseases worldwide, and its severity tends to increase with age, smoking, alcohol use, and poor access to dental care. For patients already struggling with liver disease—many of whom share these same risk factors—oral health often takes a back seat.
But ignoring the mouth could be a mistake. The review lays out multiple ways that periodontitis may aggravate liver disease. The first is via the “oral-gut-liver axis,” a term researchers use to describe the complex interplay between oral bacteria, the gut microbiome, and liver function. Pathogenic bacteria from the mouth can be swallowed or enter the bloodstream during everyday activities like chewing and brushing. Once in the gut, these microbes may alter the composition of the intestinal microbiome, leading to dysbiosis and increased gut permeability—also known as a “leaky gut.” This can allow bacterial products such as endotoxins to reach the liver, triggering inflammation and fibrogenesis.
Animal models offer further support for this theory. Studies have shown that oral administration of specific periodontal pathogens, such as Porphyromonas gingivalis, can exacerbate liver steatosis and inflammation in mice with pre-existing metabolic disease. These microbes, or their byproducts, have even been found in liver tissue, suggesting that translocation from the mouth to the liver is biologically plausible.
The immune system also plays a central role in this interaction. Chronic periodontal inflammation leads to the release of pro-inflammatory cytokines like TNF-alpha and IL-6, which have long been implicated in the progression of liver disease. Additionally, the review highlights the involvement of Th17 cells—a type of immune cell activated by oral pathogens that may migrate to the liver and worsen metabolic dysfunction. Together, these pathways form a vicious cycle: liver disease impairs oral health, while oral inflammation accelerates liver damage.
The clinical data, while still developing, supports this association. Patients with cirrhosis consistently show worse oral health than the general population, with higher rates of gingival overgrowth, attachment loss, and bone loss. The prevalence of periodontitis among patients awaiting liver transplantation can be as high as 72 percent. Studies have also found links between severe periodontal disease and increased mortality in cirrhosis patients.
For those with MASLD, the most common form of chronic liver disease, the evidence is also compelling. Population-level studies have found that people with advanced periodontitis are significantly more likely to have MASLD, even after adjusting for shared risk factors like obesity and diabetes. And in a small trial, periodontal treatment led to a short-term improvement in liver enzyme levels—a tantalizing hint that oral health interventions could influence liver function.
That said, the review authors caution that the research is still at an early stage. Much of the clinical data comes from observational studies, which cannot definitively prove cause and effect. There is also the challenge of disentangling shared lifestyle and socioeconomic factors that affect both oral and liver health. Still, the biological plausibility, consistency of findings, and preliminary interventional data make a strong case for paying more attention to the teeth and gums of patients with liver disease.
The review ends with a call for multidisciplinary collaboration. Gastroenterologists and hepatologists, who typically manage liver disease, may not think to ask about oral health or refer patients for dental care. Yet the data suggest they should. Similarly, dental professionals may not be aware of how their work could influence liver outcomes. Closer cooperation between these specialties could lead to earlier detection and better care.
Until more definitive evidence is available, one message is clear: brushing, flossing, and regular dental visits might be more important than we ever realized, especially for those living with chronic liver conditions. In the meantime, researchers are calling for larger, high-quality trials to test whether treating gum disease can slow liver disease progression or reduce complications. If the connection holds, the humble toothbrush could become an unexpected tool in the fight against liver failure.
NewsMakers
The look and feel of your neighborhood may affect your sleep
Those living in neighborhoods rated as having a stronger sense of safety tended to sleep longer, and that this rating appeared to be shaped by the streetscape.
Your neighborhood’s “streetscape”—the physical environment of your street—is something that you have probably never consciously thought about, despite seeing it every day. But what if the streetscape was affecting you on a subconscious level and disrupting your sleep?
This intriguing question is posed by the findings of a study led by Professor Daisuke Matsushita of the Graduate School of Human Life and Ecology at Osaka Metropolitan University. The research team used AI to analyze more than 200,000 Google Street View images to identify visual neighborhood characteristics. They then linked these characteristics to the self-reported sleep of 1,089 working adults living on the lower floors of apartments in Tokyo, who were most likely to be affected by the streetscape.
They found that those living in neighborhoods rated as having a stronger sense of safety tended to sleep longer, and that this rating appeared to be shaped by the streetscape. Generally, people slept longer in areas with lots of greenery, such as leafy trees, on the street. Similarly, high “enclosure”—meaning many tall vertical buildings and few wide-open spaces—was also associated with longer sleep and fewer insomnia symptoms.
However, the study also made a surprising finding. The researchers found that highly walkable streetscapes, such as those with more sidewalks and traffic signs, were associated with a lowered sense of safety and shortened sleep duration.
This suggests that walkability does not always represent a reassuring environment. Instead, a possible explanation is that streets with extensive pedestrian infrastructure are often busier, more crowded, and used by more strangers, which may be perceived as less safe or less relaxing than quieter residential streets.
“This study demonstrates the potential for evaluating streetscape characteristics across large geographic areas in a cost-effective manner,” Dr. Matsushita said. “Based on the technique used in this study, cities could potentially measure perceived safety, beauty, liveliness, and enclosure as well as pollution and noise.”
“We hope that opening up this new perspective creates further possibilities for designing healthier neighborhoods,” he concludes.
The findings were published in Building and Environment.
NewsMakers
Workout or nap? Either can help your sleepless brain, study finds
People who either completed 20 minutes of moderate-to-vigorous exercise or took a 90-minute nap performed about 22 per cent better on memory tests after 30 hours without sleep than those who did neither.
A short workout or a nap can help protect memory after a sleepless night, a McGill University-led study has found.
Researchers found people who either completed 20 minutes of moderate-to-vigorous exercise or took a 90-minute nap performed about 22 per cent better on memory tests after 30 hours without sleep than those who did neither. The findings, published in Proceedings of the National Academy of Sciences (PNAS), point to practical ways to counter the effects of sleep deprivation.
“Sleep loss affects nearly every aspect of how we think and function, but many people can’t simply stop what they’re doing and get more sleep,” said senior author Marc Roig, Professor in McGill’s School of Physical and Occupational Therapy. “Our findings show that even a brief bout of exercise may help preserve one of our most important cognitive abilities.”
The study involved 54 healthy young adults who stayed awake for 30 consecutive hours under lab supervision. Participants were then assigned to one of three groups: a 20-minute cycling session, a 90-minute nap or a control condition. Three days later, researchers tested their memory for images they had viewed immediately after the intervention. Those who exercised or napped remembered significantly more images than participants who did neither.
Same result, different pathways
While the memory benefits were nearly identical, brain recordings revealed that exercise and napping helped in different ways.
Napping appeared to help the brain recharge, making it easier to take in and remember new information. Exercise, by contrast, helped the brain use its remaining resources more efficiently, without making participants feel more tired.
The findings could eventually inform fatigue-management strategies in workplaces where sleep loss is common and mistakes can have serious consequences, such as health care, transportation and emergency response.
“A nap isn’t always possible in the middle of a shift,” said first author Madhura Lotlikar, a doctoral candidate in McGill’s Department of Neurology and Neurosurgery. “Exercise is accessible, inexpensive and easy to implement. That makes it a promising tool to help people stay cognitively sharp when sleep is limited.”
The researchers emphasize that exercise cannot replace sleep, but it may help people function better when getting enough rest isn’t possible.
About the study
“Protecting episodic memory after sleep loss: Similar benefits of exercise and naps via distinct neural contributions” by Madhura Lotlikar and Marc Roig et al., was published in Proceedings of the National Academy of Sciences of the United States of America.
NewsMakers
Study links coffee consumption to metabolic health and sex hormones
Despite having a similar body mass index (BMI), individuals with higher coffee consumption had lower total and visceral fat and greater skeletal muscle mass than those who consumed less coffee.
Coffee is one of the world’s most widely consumed beverages, and previous research has linked its consumption to a lower risk of conditions such as type 2 diabetes and cardiovascular disease. However, the biological mechanisms behind these benefits remain unclear. A new Finnish study links habitual coffee consumption to healthier body composition and metabolic markers, while revealing distinct associations with sex hormones in men and women.
The study, conducted at the University of Oulu, analysed data from 2,264 participants aged 46 in the Northern Finland Birth Cohort 1966. Researchers examined how habitual coffee consumption was associated with circulating metabolites, cardiometabolic risk markers and sex hormones.
Despite having a similar body mass index (BMI), individuals with higher coffee consumption had lower total and visceral fat and greater skeletal muscle mass than those who consumed less coffee.
In both men and women, higher coffee consumption was correlated with lower circulating levels of branched-chain amino acids, biomarkers that have previously been linked to insulin resistance and an increased risk of type 2 diabetes when chronically elevated.
The strongest sex-specific associations were observed in men. Higher coffee consumption was linked to a more favourable glucose–insulin profile, higher concentrations of total and bioavailable testosterone, and increased levels of sex hormone-binding globulin (SHBG). At the same time, free testosterone and the free androgen index were modestly lower. In women, hormonal associations were more limited and were primarily characterised by higher SHBG and lower measures of free androgens.
“Coffee is consumed by millions of people every day, yet we still know surprisingly little about how it relates to our metabolism and hormones. What stood out in our findings was a distinct hormonal signature that didn’t disappear even after we took into account BMI and lifestyle factors, with several of these associations differing between men and women,” says Luca Verroest, lead author of the study and Doctoral Researcher at the University of Oulu.
The results suggest that hormonal pathways may partly explain the relationship between coffee consumption and metabolic health. However, as this was an observational study, the findings demonstrate associations rather than cause-and-effect relationships.
The study is particularly relevant in Finland, one of the world’s highest coffee-consuming countries, where annual consumption averages around 11.8 kilograms per person.
The researchers say the findings provide a foundation for future studies aimed at determining whether coffee itself drives these biological changes and identifying the compounds responsible. These questions are currently being investigated in animal models, with the long-term goal of progressing to human intervention studies. Further research will be needed before the findings could inform dietary recommendations.
The study, Associations of habitual coffee intake with testosterone and cardiometabolic markers: the Northern Finland Birth Cohort 1966 study, has been published in the European Journal of Nutrition.
-
NewsMakers4 weeks agoScheduling dental care during prenatal visits boosts oral health care during pregnancy
-
Destinations2 weeks agoPasalubong shopping in Davao via Aldevinco
-
NewsMakers4 weeks agoStudy links coffee consumption to metabolic health and sex hormones
-
Product Showcase4 weeks agoManulife Investments Philippines leads UITF rankings across equity and fixed income funds
-
NewsMakers3 weeks agoThe look and feel of your neighborhood may affect your sleep
-
NewsMakers3 weeks agoWorkout or nap? Either can help your sleepless brain, study finds
-
Destinations1 week agoHeading to Pila, Laguna? Check out La Cosina Antonio
