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Intermittent fasting shows promise in improving gut health, weight management

Participants following an intermittent fasting and protein-pacing regimen, which involves evenly spaced protein intake throughout the day, saw better gut health, weight loss and metabolic responses.

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A new study by researchers from Arizona State University and their colleagues highlights a dietary strategy for significant health improvement and weight management.

Participants following an intermittent fasting and protein-pacing regimen, which involves evenly spaced protein intake throughout the day, saw better gut health, weight loss and metabolic responses. These benefits were notably greater than those seen with simple calorie restriction.

The findings, reported in the journal Nature Communications, could advance our understanding of the relationship between the gut microbiome and metabolism and improve strategies for managing obesity.

The researchers compared the effects of two low-calorie dietary interventions: a heart-healthy continuous calorie-restricted diet (based on USDA dietary recommendations), and a calorie-restricted regimen incorporating intermittent fasting and protein pacing.

The trial was conducted with 41 individuals who were overweight or obese over a period of eight weeks. Individuals in the intermittent fasting and protein-pacing group showed a decrease in symptoms of gastrointestinal problems and an increase in diversity of the gut microbiota compared with those in the calorie-restriction group.

The intermittent fasting protocol increased beneficial microbes in the gut that have been linked to a lean body type and improved overall health. Additionally, it increased the levels of certain proteins (cytokines) in the blood associated with weight loss, as well as amino acid byproducts that promote fat burning.

Intermittent fasting is an eating pattern that cycles between periods of fasting and eating. The method has recently gained popularity for its potential health benefits, including weight loss, improved metabolic health and enhanced brain function.

“Given the gut microbiota’s location and its constant interaction with the GI tract, we have been gaining a deeper understanding of its pivotal role in dietary responses these last several years,” says Alex Mohr, lead author of the new study. “While limited in duration and sample size, this comprehensive investigation — which included the analysis of the gut microbiome, cytokines, fecal short-chain fatty acids and blood metabolites — underscores the intricate interplay between diet, host metabolism and microbial communities.”

Mohr led the microbiome and molecular investigations, evaluating gut microbial composition, inflammatory molecules called cytokines, SCFAs (metabolites derived from dietary fiber, important for regulating energy balance) and the metabolome.

Mohr is a researcher with the Biodesign Center for Health Through Microbiomes at ASU. Rosa Krajmalnik-Brown, the center director, and researchers Devin Bowes, Karen Sweazea and Corrie Whisner are also contributors to the study.

Corresponding author Paul Arciero of the Department of Health and Human Physiological Sciences at Skidmore College led the clinical trial, which tracked weight loss and body composition.

The study also included contributions from ASU researchers Paniz Jasbi and Judith Klein-Seetharaman, with the School of Molecular Sciences, and Dorothy Sears and Haiwei Gu, with the College of Health Solutions.  

Diet, microbiome and weight loss

The gut microbiome refers to the diverse community of microorganisms residing in the gastrointestinal tract, including bacteria, viruses, fungi and other microbes. Numbering in the many trillions of organisms, this complex ecosystem plays a crucial role in essential bodily functions and overall health.

The gut microbiome helps break down food, produce vitamins and promote the absorption of nutrients. It plays a role in the development and function of the immune system by protecting the body against harmful pathogens. Finally, the gut microbiome keenly regulates metabolism,  impacting body weight, fat storage and insulin sensitivity.

Caloric restriction, intermittent fasting (limiting food consumption to certain windows on some days) and protein pacing (controlled protein intake at specific meals) have been shown to affect body weight and composition, but the effect of these dietary modifications on the gut microbiome has been unclear until now.

“A healthy gut microbiome is essential for overall health, particularly in managing obesity and metabolic diseases,” says Sweazea, the ASU principal investigator of this Isagenix-funded study. “The gut bacteria influence how we store fat, balance glucose levels and respond to hormones that make us feel hungry or full. Disruptions in the gut microbiota can lead to increased inflammation, insulin resistance and weight gain, underscoring the critical role of gut health in preventing and managing metabolic disorders.”

Study and findings

The clinical trial involved 27 female and 14 male participants who were overweight or obese.  Participants were divided into two groups: one following the intermittent fasting and protein pacing regimen, and the other adhering to a heart-healthy, calorie-restricted diet. Both groups were monitored over eight weeks for changes in weight, body composition, gut microbiome composition and plasma metabolomic signatures.

Participants following the intermittent fasting and protein pacing regimen experienced a significant reduction in gut symptoms and an increase in beneficial gut bacteria, particularly from the Christensenellaceae family. The study also found these microbes are associated with improved fat oxidation and metabolic health. In contrast, the calorie-restricted group showed an increase in metabolites linked to longevity-related pathways.

Despite both groups having similar average weekly energy intake, the intermittent fasting and protein pacing group achieved greater weight loss and fat reduction with an average loss of 8.81% of their initial body weights during the study. In comparison, those on a calorie-restricted diet lost an average of 5.4% body weight.

Participants who followed the intermittent fasting and protein-pacing diet experienced reductions in overall body fat, including belly fat and deep abdominal fat, and saw an increase in the percentage of lean body mass.

The study underscores the potential of intermittent fasting and protein-pacing diets in improving gut health and weight management. While further research is necessary, these findings offer a promising avenue for creating effective dietary interventions for obesity and related metabolic disorders.

“By identifying shifts in specific microbes, functional pathways and associated metabolites, this line of work holds promise for personalized health strategies as we can better tailor nutritional regimens to enhance gut function and metabolic outcomes,” Mohr says.

Additional institutions contributing to the study: Systems Precision Engineering and Advanced Research (SPEAR); Center of Translational Science, Florida International University; Isagenix International LLC; and the School of Health and Rehabilitation Sciences, Department of Sports Medicine and Nutrition, University of Pittsburgh.

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Millennials and Gen Zs prioritize health, purpose, financial independence, but health and wellness gaps persist

Younger Filipinos are placing greater emphasis on healthspan, purpose, and financial independence. However, the study also revealed that while 83% of young respondents have good knowledge about health and wellness, only 76% say they are taking sufficient action to consistently practice healthy habits.

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While millennials and Gen Zs in the Philippines are reshaping what it means to live well and live long, significant gaps between awareness and action jeopardize their health, wellness, and longevity aspirations, a new study by Manulife Philippines has found.

According to “#FYP: Future-proofing Young Pinoys: Examining Health and Longevity Perspectives, Sentiments, and Aspirations of Millennials and Gen Zs,” which was conducted among 500 respondents across the Philippines, younger Filipinos are placing greater emphasis on healthspan, purpose, and financial independence. However, the study also revealed that while 83% of young respondents have good knowledge about health and wellness, only 76% say they are taking sufficient action to consistently practice healthy habits.

“With a median age of 26.1, the Philippines has one of the youngest populations in Asia. Our latest study highlights the need to support younger generations in translating their health, wellness, and longevity aspirations into meaningful action. We found that millennials and Gen Zs are motivated to live healthier lives, but barriers like stress, excessive screen time, and sleep deprivation, among many others are holding them back from achieving this goal,” said Rahul Hora, President and Chief Executive Officer, Manulife Philippines.

Motivated to be healthy, but stress gets in the way; Millennial women among the most affected

The study found that millennials and Gen Zs are not short of motivation to pursue their health and wellness goals. While 64% said they are pursuing health to avoid getting sick, and 44% said they want to minimize potential medical expenses, many are equally driven by their personal well-being and self-image about feeling and looking good: 44% said they want to look good or fit, and 43% said they want to look youthful.

Younger Filipinos, especially women, are also putting more focus on healthspan, or the number of the years we live healthily, over lifespan. According to the survey, 60% of female respondents prefer to prolong their healthspans, while 53% of males prefer to prolong their lifespans.

Filipino millennials and Gen Zs face notable health and wellness gaps, from monitoring to their actual wellness behaviors:

  • Young Filipinos show significant gaps in health monitoring (awareness vs what they actually monitor), particularly in mobility (24%), nutrition (23%), and cholesterol levels (20%). Gender differences are evident, with young women struggling more with nutritional monitoring (27%) and young men facing greater challenges in mobility monitoring (28%).
  • Many young Filipinos find it difficult to consistently maintain healthy sleeping habits (20%), achieve work-life balance (19%), and follow a balanced diet (15%). Women report a larger gap in achieving work-life balance at 22%, compared to the 15% gap among men.
  • Stress is the most prominent barrier to wellness, affecting 64% of respondents. Millennials report higher stress levels than Gen Zs (69% vs. 58%), and women are more affected than men (73% vs. 55%). Notably, 76% of millennial women say stress prevents them from pursuing their desired wellbeing—the highest among all generational and gender groups.
  • Modern lifestyle habits further compound these issues, with excessive screen time impacting 48% and sleep deprivation affecting 45% of young Filipinos. Trends such as “bedrotting” and “doomscrolling” reflect how contemporary behaviors are undermining their wellness goals.

“We’re seeing that for young Filipinos, intent alone isn’t sufficient. While many are motivated to pursue healthier lives, they’re facing a complex mix of stressors and lifestyle gaps, which make it difficult to follow through. These habits quietly derail their ability to prioritize wellness. That’s why the next step is to find ways to embed wellness into their daily routine. By offering health and wellness-focused programs and collaborations with likeminded partners, we are helping them bridge the gap between intention and action, turning wellness goals into sustainable, everyday behaviors supporting their long-term health and longevity aspirations,” added Hora.

Younger Filipinos view age positively and prioritize attaining purpose and living independently than being illness-free

According to the study, 96% of millennials and Gen Zs surveyed believe aging is a natural process that should be embraced with positivity, while 91% of the respondents believe that living a meaningful life is more important than living a long one. The study revealed a striking perspective on aging priorities, with 83% of respondents believing that living independently and being able to do things that matter most to them is more important than being illness-free.

Millennials surveyed focus more on physical health and family relationships as they age. Gen Zs, on the other hand, lean toward self-discovery, purpose, and making an impact. Only 13% of both generations consider maximizing lifespan as a top priority, with men showing slightly higher interest (17%) compared to women (8%).

“The findings reveal that young Filipinos see aging not as decline, but as a chance to live with purpose and independence,” Hora said. “It is therefore crucial that we create opportunities and support systems for them to live better at every stage of their lives. This means investing in holistic wellness programs, accessible financial health education, as well as tools that address both physical and mental needs, tailored especially for younger generations navigating various stressors of the modern world.”

“As one of the country’s longest-serving insurers, Manulife Philippines is deeply committed to supporting younger generations of Filipinos in their journey toward financial independence and longevity. Through our innovative insurance and investment solutions, and our nationwide network of over 10,000 professional financial advisors, we aim to empower millennials and Gen Zs to live fuller, healthier lives with purpose and confidence as they age,” said Hora.

Financial independence: Younger Filipinos’ ultimate longevity concern

When it comes to living a longer life but also “adding life to years,” financial security tops the list of concerns for both generations. Among the respondents, 74% believe that longevity is a blessing only if they have sufficient financial resources, with running out of money being their greatest worry (61%). Millennials and Gen Zs agree that mental health is a top longevity concern (36% and 47%, respectively). Millennials surveyed are more concerned about keeping ties with children (37%), while Gen Zs are more concerned about living their desired lifestyle (39%). 

Gaining financial independence is also a top longevity priority for young Filipinos (52%), followed by family relationships (36%) and physical health (33%). Women, however, prioritize financial independence significantly more than men (60% vs. 44%). This gender gap reflects broader structural realities women face in the Philippines. Despite having longer life expectancies (69.9 vs 63.4), women have lower labor force participation (52.9% vs 76.3%) and are prone to career interruptions due to family and caregiving responsibilities. These factors make financial independence especially urgent for women, who must plan for longer retirement years with potentially fewer financial opportunities.

Financial planning remains one of the many challenges the youth face. Gen Zs surveyed estimate needing PHP22.3 million to achieve financial independence upon retirement, while millennials estimate PHP18.4 million. Yet only 20% of respondents have very high confidence in achieving these goals. Despite the challenges, young Filipinos take proactive steps. Among those who prioritize financial independence, 65% save part of their income, 45% purchase insurance, and 43% actively broaden their financial knowledge. However, 68% admit that sustaining investments remains difficult.

“It’s encouraging to see today’s younger generations starting to take more proactive steps toward financial planning. We’re seeing a shift in mindset, where millennials and Gen Zs are actively saving, purchasing insurance, and expanding their financial literacy. These are promising signs,” said Aira Gaspar, President and Chief Executive Officer, Manulife Investments Philippines.

“The key now is to help them bridge the gap between intention and sustained action, through accessible, flexible investment strategies that evolve with their life stages, financial capabilities, and aspirations. By enabling them with the right tools and guidance, we can help turn financial independence into a tangible, achievable reality for our younger customers in the Philippines,” added Gaspar.

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Drinking any amount of alcohol likely increases dementia risk

Even light drinking—generally thought to be protective, based on observational studies—is unlikely to lower the risk, which rises in tandem with the quantity of alcohol consumed.

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Drinking any amount of alcohol likely increases the risk of dementia, suggests the largest combined observational and genetic study to date, published online in BMJ Evidence Based Medicine.

Even light drinking—generally thought to be protective, based on observational studies—is unlikely to lower the risk, which rises in tandem with the quantity of alcohol consumed, the research indicates.

Current thinking suggests that there might be an ‘optimal dose’ of alcohol for brain health, but most of these studies have focused on older people and/or didn’t differentiate between former and lifelong non-drinkers, complicating efforts to infer causality, note the researchers.

To try and circumnavigate these issues and strengthen the evidence base, the researchers drew on observational data and genetic methods (Mendelian randomisation) from two large biological databanks for the entire ‘dose’ range of alcohol consumption.

These were the US Million Veteran Program (MVP), which includes people of European, African, and Latin American ancestry, and the UK Biobank (UKB), which includes people of predominantly European ancestry.

Participants who were aged 56–72 at baseline, were monitored from recruitment until their first dementia diagnosis, death, or the date of last follow-up (December 2019 for MVP and January 2022 for UKB), whichever came first. The average monitoring period was 4 years for the US group, and 12 for the UK group. 

Alcohol consumption was derived from questionnaire responses—over 90% of participants said they drank alcohol—and the Alcohol Use Disorders Identification Test (AUDIT-C) clinical screening tool. This screens for hazardous drinking patterns, including the frequency of binge drinking (6 or more drinks at a time).

In all, 559,559 participants from both groups were included in observational analyses, 14,540 of whom developed dementia of any type during the monitoring period:10,564 in the US group; and 3976 in the UK group. And 48,034 died: 28,738 in the US group and 19,296 in the UK group. 

Observational analyses revealed U-shaped associations between alcohol and dementia risk: compared with light drinkers (fewer than 7 drinks a week) a 41% higher risk was observed among non-drinkers and heavy drinkers consuming 40 or more drinks a week, rising to a 51% higher risk among those who were alcohol dependent. 

Mendelian randomisation genetic analyses drew on key data from multiple large individual genome-wide association studies (GWAS) of dementia, involving a total of 2.4 million participants to ascertain lifetime (rather than current) genetically predicted risks.

Mendelian randomisation leverages genetic data, minimising the impact of other potentially influential factors, to estimate causal effects: genomic risk for a trait (in this case, alcohol consumption) essentially stands in for the trait itself. 

Three genetic measures related to alcohol use were used as different exposures, to study the impact on dementia risk of alcohol quantity, as well as problematic and dependent drinking. 

These exposures were: self-reported weekly drinks (641 independent genetic variants);  problematic ‘risky’ drinking (80 genetic variants); and alcohol dependency (66 genetic variants). 

Higher genetic risk for all 3 exposure levels was associated with an increased risk of dementia, with a linear increase in dementia risk the higher the alcohol consumption. 

For example, an extra 1-3 drinks a week was associated with a 15% higher risk. And a doubling in the genetic risk of alcohol dependency was associated with a 16% increase in dementia risk.

But no U-shaped association was found between alcohol intake and dementia, and no protective effects of low levels of alcohol intake were observed. Instead, dementia risk steadily increased with more genetically predicted drinking. 

What’s more, those who went on to develop dementia typically drank less over time in the years preceding their diagnosis, suggesting that reverse causation—whereby early cognitive decline leads to reduced alcohol consumption—underlies the supposed protective effects of alcohol found in previous observational studies, say the researchers.

They acknowledge that a principal limitation of their findings is that the strongest statistical associations were found in people of European ancestry, because of the numbers of participants of this ethnic heritage studied. Mendelian randomisation also relies on assumptions that can’t be verified, they add.

Nevertheless, they suggest that their findings “challenge the notion that low levels of alcohol are neuroprotective.”

And they conclude: “Our study findings support a detrimental effect of all types of alcohol consumption on dementia risk, with no evidence supporting the previously suggested protective effect of moderate drinking. 

“The pattern of reduced alcohol use before dementia diagnosis observed in our study underscores the complexity of inferring causality from observational data, especially in ageing populations. 

“Our findings highlight the importance of considering reverse causation and residual confounding in studies of alcohol and dementia, and they suggest that reducing alcohol consumption may be an important strategy for dementia prevention.”

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Distribution of fat could influence cancer risk, study suggests

Obesity is usually measured using body mass index (BMI), but growing evidence – particularly from heart health research – suggests that BMI alone doesn’t capture the full picture when it comes to obesity-related health risks. However, the role of fat distribution in cancer risk has been relatively unexplored.  

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How fat is distributed in people’s bodies could make a difference to their risk of certain cancers, according to new research led by the University of Bristol.  The international study is published in the Journal of the National Cancer Institute (JNCI).

Scientists have already shown that having obesity increases a person’s risk of developing certain cancers. Obesity is usually measured using body mass index (BMI), but growing evidence – particularly from heart health research – suggests that BMI alone doesn’t capture the full picture when it comes to obesity-related health risks. However, the role of fat distribution in cancer risk has been relatively unexplored.  

Researchers in Bristol’s Integrative Cancer Epidemiology Programme (ICEP) investigated whether body fat at different locations across the body influences the risks of 12 obesity-related cancers – endometrial, ovarian, breast, colorectal, pancreas, multiple myeloma, liver, kidney (renal cell), thyroid, gallbladder, oesophageal adenocarcinoma, and meningioma.

They used a technique known as Mendelian randomisation, which uses statistics, computing and the natural variations in people’s genetics to identify patterns in large health data sets. 

The team found that fat distribution appears to influence cancer risk – but the relationship varies by cancer type. For some cancers, where fat is stored in the body seems more important than how much is stored; for others, the reverse is true; and, for some, both matter.  In cancers where distribution is important, the specific locations of body fat driving this seem to differ by cancer, meaning the overall picture is quite complex. 

Lead author, Dr Emma Hazelwood, who recently completed her PhD at the University of Bristol, explained: “These findings support the growing consensus that BMI, while useful for population-level trends, may be too simplistic for assessing individual health risks.

“Our results tell us that there is no ‘one-size-fits-all’ when it comes to cancer, meaning a more tailored approach to cancer prevention in people with obesity could be most effective.” 

The paper’s findings fit with recent calls for change, including the 2024 European Association for the Study of Obesity framework and the Lancet Commission on the future of obesity, which have emphasised that BMI is a flawed diagnostic tool and that fat distribution matters.  

In the future, a better understanding of how fat distribution across the body affects cancer risk could help identify those most at risk and guide more personalised approaches to obesity treatment and cancer prevention. 

The research team recommend further work is needed, using different approaches and studying non-European populations.

Dr Hazelwood added: “It is vital to understand the biological mechanisms that underpin these associations – particularly how and why different fat depots affect cancer development. In the longer term, we need to explore how obesity treatments – whether lifestyle or drug-based – influence these risk pathways.” 

Dr Julia Panina, Head of Research Funding at World Cancer Research Fund, added: “Our evidence-based Cancer Prevention Recommendations highlight the role of maintaining a healthy weight to reduce cancer risk. While this remains essential, growing scientific evidence shows that body composition – particularly how fat is distributed throughout the body – is also a crucial factor.  

“With support from our fantastic donors, we were able to co-fund the University of Bristol’s excellent team whose findings will help direct this exciting area towards possible new cancer prevention and treatments.” 

This study was funded by the World Cancer Research Fund (WCRF UK) and Cancer Research UK (Integrative Cancer Epidemiology Programme). This work was carried out at the MRC Integrative Epidemiology Unit (MRC IEU), which is supported by the Medical Research Council (MRC) and the University of Bristol. 

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