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Combination of drugs for obesity and Type 2 diabetes may be more effective than a single therapy

The researchers conclude that combining the drugs has several advantages, including higher effectiveness in at least some patients and fewer side-effects.

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Canadian and German researchers are teaming up to identify new drug combinations to treat people with obesity and Type 2 diabetes. 

The goal is to develop personalized prescriptions that are more effective than single drugs and that can potentially replace more invasive treatments such as bariatric surgery, especially for children. 

“As a pediatric endocrinologist, I can tell you we’re seeing more and more Type 2 diabetes in kids and adolescents, and it seems to be a more aggressive form than adult onset diabetes, so we do need better therapies to achieve even greater efficacy and degree of weight loss,” said Andrea Haqq, a professor in the University of Alberta’s Faculty of Medicine & Dentistry.

The researchers recently published a paper that examines the potential of several drugs that control incretins. These metabolic hormones stimulate the body to produce insulin and use it effectively. They also suppress appetite in order to control blood sugars and reduce weight. 

The researchers conclude that combining the drugs has several advantages, including higher effectiveness in at least some patients and fewer side-effects. 

Even a five per cent weight loss is considered clinically meaningful, and patients in some of the combination drug trials are achieving 10 or 15 per cent, said Haqq, who is a member of the Alberta Diabetes Institute and the Women and Children’s Health Research Institute. 

Haqq’s laboratory is collaborating with that of Timo Müller, director of the Institute for Diabetes and Obesity at the Helmholtz Diabetes Center and a researcher with the German Center for Diabetes Research in Münich, Germany.

As part of the collaboration with the Müller team, first author Qiming Tan, a PhD candidate in the U of A Faculty of Medicine & Dentistry, will study for a term in Germany and a German student will join Haqq’s lab here.

Haqq and Tan recommend further research to identify why some individuals respond differently to the drugs. Some racial and ethnic groups bear a disproportionate burden of obesity and Type 2 diabetes, they said, so more participants from these groups are needed in trials. Further studies should also focus on how differences in biological sex affect drug efficacy and safety. 

In addition to drug combinations, the researchers are looking for non-pharmacological solutions, such as how adding fibre to a person’s diet can slow weight gain and improve the effectiveness of existing diabetes medications.

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DKT Philippines Foundation unveils PH’s first family planning mobile clinic

The SODEX Mobile Clinic is an innovation to improve DKT Philippines Foundation’s SODEX Program and its contribution to achieving the DOH 8-Point Action Agenda and National Objectives for Health.

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DKT Philippines Foundation, a charitable non-profit organization promoting family planning and HIV prevention, officially launched the SODEX (Service Outreach and Distribution Extension Program) Mobile Clinic – the country’s first-ever family planning ambulatory clinic. This pioneering effort aims to provide safe and accessible modern family planning methods for Filipinos in far-flung areas to bridge the gap between Filipinos wanting to space and limit pregnancy and the disparities in Family Planning service provision.

The SODEX Mobile Clinic is an innovation to improve DKT Philippines Foundation’s SODEX Program and its contribution to achieving the DOH 8-Point Action Agenda and National Objectives for Health.

“DKT Philippines Foundation’s mission is to provide couples with affordable, and safe options for family planning, and HIV/AIDS prevention through dynamic social marketing,” said Loida Almendares, the Foundation’s Director of Programs. “The SODEX mobile clinic will provide a wide array of free family planning services especially in areas with lesser access to services like the geographically isolated or socially disadvantaged areas. The mobile clinic will bring the services closer to the people and meet them where they are,” she added.

The mobile clinic will provide free Family Planning commodities such as pills, condoms, injectables and intrauterine devices (IUD). It will also offer free bilateral tubal ligation (BTL) using local anesthesia and non-scalpel vasectomy (NSV). Onboarding the clinic are Physician/Surgeon trained on the provision of BTL, NSV, IUD, and subdermal implant services; FP-trained nurse; FP- trained midwife; a circulating staff, and a driver. To ensure that all clients are well-informed and fit to take the services, they will undergo counseling and final screening prior to getting the method.

In partnership with 30 LGUs from Luzon, DKT Philippines Foundation aims to foster sustainable and long-term partnerships with these LGUs to cultivate Filipinos’ desire to meaningfully participate and contribute to government efforts to achieve universal health coverage for all.

“DKT Philippines Foundation and its Family Planning Mobile Clinic reinforce DKT’s commitment to ensuring nobody is left behind and provides free and quality reproductive health options including permanent methods, to those most remote and vulnerable communities. Made possible by the sales of family planning products under the TRUST Reproductive Health Choices brand, the mobile clinic ensures that people who still cannot afford the highly affordable TRUST products, or cannot access the reproductive health services they need in the public sector, are not left behind and still have free access to these services. It is a part of a total market approach, complementing the important work the local LGUs do on a daily basis.” said Denise van Dijk, Chair of the Board of DKT Philippines Foundation.

The mobile clinic will travel for 119 days to offer free services in the provinces of Central Luzon, North Luzon, Cordillera, MIMAROPA and CALABARZON with the first stop being at Binangonan, Rizal where the launch took place. The clinic will stay in one area for a day or two from 8 AM to 6 PM. By next year, the mobile clinic will cover communities in the Visayas and Mindanao areas. 

The launch and blessing event was officially attended by fellow reproductive health advocates in public and private sectors, development partners, and family planning clients.  Guest of honor and speaker was Department of Health Undersecretary Dr. Glenn Mathew Baggao with special participation of the Mayor of Binangonan, Rizal – Hon. Cesar M. Ynares.

The programs and free services of DKT Philippines Foundation are made possible by the country’s leading brand of contraceptives TRUST Reproductive Health Choices, which is carried by the social enterprise DKT Health, Inc.

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Pru Life UK ramps up recruitment efforts

Through a series of Build Your Business (BYB) sessions—held online and in person in key cities across the country—seasoned PRU business builders share their success stories and tips to encourage attendees to pursue their own business goals.

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Pru Life UK ramps up its recruitment efforts to empower ambitious individuals from all walks of life to build a long-lasting business with the leading life insurer.

Through a series of Build Your Business (BYB) sessions—held online and in person in key cities across the country—seasoned PRU business builders share their success stories and tips to encourage attendees to pursue their own business goals.

“By choosing Pru Life UK, aspiring financial advisors can be confident that they are backed by the #1 life insurer in the country with strong market presence and solid financial results,” said Marylin Detalla-Averia, Chief Agency Officer of Pru Life UK.

The company ranks number one in the life insurance industry in the Philippines, garnering the highest New Business Annual Premium Equivalent based on the Insurance Commission’s report as of 31 December 2023.

“Our financial advisors are provided with all the support they need to help build their business. They have access to digital tools, development programs, hip offices, and attractive rewards and incentives with unlimited earning potential. This allows them to be their own boss and live their ideal lifestyle while helping clients achieve theirs.”

Celebration of success with #BuildYourPRUBusiness

While BYB sessions are held year-round, the company leads an energetic approach to recruitment this May.

Themed Paint the Town Red: It’s PRUFiesta time, Recruitment Never Stops!, BYB sessions will be held in  Metro Manila (Makati, Ortigas, QC), Pampanga (Clark, Sta. Rosa), South (Alabang, Lipa), North (Baguio), and VisMin (Cebu, Davao, CDO).

Attendees will receive mentorship on becoming a business builder with Pru Life UK’s 40,000-agency force, the largest in the industry.

A virtual BYB session will happen on May 22 featuring “Pambansang Wealth Coach” Chinkee Tan, who will talk about financial management and business development, further highlighting the importance of financial planning and empowering entrepreneurial mindset.

Pru Life UK also holds its weekly Facebook live Q&A sessions for budding and experienced business builders. Held every Thursday at 7:00 p.m., these online sessions offer a glimpse into the world of financial advisors. 

Seeking a meaningful and rewarding business opportunity? Visit bit.ly/JoinPRU2024 to join Pru Life UK’s BYB sessions.

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BAFI, USAID deliver biodiversity projects, MIND S-COOL TV and Biodiversity Crisis Escape Room

Both projects serve to innovatively highlight the critical concepts of “roles” and “collaboration” in addressing the biodiversity crisis as well as the “measures” of the values, not only monetary, that we should all consider living with nature.

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Bonifacio Art Foundation, Inc. (BAFI) and the United States Agency for International Development have joined forces to bring you a two-part biodiversity special of MIND S-COOL TV as well as a traveling Biodiversity Crisis Escape Room (BCER). Both projects serve to innovatively highlight the critical concepts of “roles” and “collaboration” in addressing the biodiversity crisis as well as the “measures” of the values, not only monetary, that we should all consider living with nature.

BCER is the first, traveling, experiential, immersive space, made up of 3 main rooms that will stand for the biodiversity crisis. The goal is for the participants to escape the crisis TOGETHER by helping one another realize and fulfill their roles. BCER will be hosted by BAFI’s The Mind Museum right after its opening at the museum on May 22 and will travel to host venues in Subic (Harbor Point, June15), Puerto Princesa (Robinson’s Mall, June 29) and Davao (Abreeza Mall, July 27) to enjoin participants who include – legislators, enforcers, regulators as well as community leaders – including cultural leaders AND local flora and fauna as well in the form of life-sized moving puppets, manned by professional puppeteers. It will also welcome the general public to experience this very unique and meaningful escape room on the dates mentioned.

Inside BCER, participants will take on roles that they would randomly pick. They will enter 3 connected rooms that they could only escape from if they understand what needs to be done and that they work together. The challenges they will face in each room are closely tied to realizing the “Mga Sukat ng Kalikasan” (measures/values of nature) in order to escape the biodiversity crisis. The experience will be facilitated so it will mimic the real human conversations and actions that need to happen in decision-making involving our natural heritage in which we all share in terms of not just benefits but also responsibilities. 

The 2-part biodiversity special of MIND S-COOL TV, the #1 science show across all channels[1] is a TV version of BCER fleshing out a narrative that will involve our main questers as well as non-human “players” who will be called to help out since MIND S-COOL has been held hostage by the biodiversity crisis. They will experience being trapped in the rooms together with other characters, including life-sized puppets that represent non-humans such as flora, fauna, habitats, abiotic elements giving nature a “voice”. The story of this special 2-part can be summarized as “all life is embedded in nature and we need to realize its many values because if we don’t, the quality of our interconnected lives will be degraded.”  Part 1 of this special will air on May 26, 11 am and replayed at 4:30 PM on OnePh Channel on Cignal while part 2 will air the week after. These will be followed by replays for 6 weeks.

Kathy Wachala, Chief of Party for USAID’s Sustainable Interventions for Biodiversity, Oceans and Landscapes (SIBOL) project, says: “This partnership with BAFI to do BCER and MIND S-COOL TV enabled us to roll-out a very powerful way for stakeholders to internalize their actual roles and work together to come up with solutions to the biodiversity crisis.” Maria Isabel Garcia, Managing Director/Curator of BAFI, also comments on the project, saying, “We are so inspired by the kind of partnership we have with USAID SIBOL since it allowed us to recruit very imaginative ways of engagement for science to serve life, biodiversity.”

We can all escape the biodiversity crisis if we understand that all lives are interconnected and that we all work together, now.

To know more about the USAID SIBOL project and its interventions, you may send an email to info@ph-sibol.org.

Mind S-Cool TV and Biodiversity Crisis Escape Room were conceived and created by the Bonifacio Art Foundation, Inc., the creator and operator of The Mind Museum and the BGC Arts Center.

To know more, or if you wish to know how you can support mind s-cool and the other projects of the Bonifacio Art Foundation, send an inquiry to: mindscool@bafi.org.ph, inquiry@themindmuseum.org or info@bgcartscenter.org.


[1] According to the latest Nielsen Ratings Survey

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