A Mount Sinai study provides compelling evidence that exercise can significantly help the mental well-being of millions of women living with chronic pelvic pain disorders (CPPDs), such as endometriosis and uterine fibroids.

The researchers at the Icahn School of Medicine at Mount Sinai found that activities like brisk walking or aerobic exercise can lead to measurable improvements in mental well-being, regardless of pain levels or history of anxiety or depressive disorders. Their findings were reported in the February 26 online issue of the Journal of Pain Research.

CPPDs affect millions of women worldwide, leading to increased health care costs, reduced quality of life, and a higher risk of anxiety and depression, yet effective management strategies remain limited. This study highlights the potential of physical activity as a simple and accessible way to enhance mental well-being, say the investigators.

“Chronic pelvic pain disorders are incredibly complex and burdensome for those affected, yet we still have very few effective treatment strategies,” says lead corresponding author Ipek Ensari, PhD, an Assistant Professor in the Windreich Department of Artificial Intelligence and Human Health at the Icahn School of Medicine and a member of the Hasso Plattner Institute of Digital Health at Mount Sinai. “Our research suggests that physical activity could be an important tool for improving mental health in these patients, offering them a proactive way to enhance their well-being.”

The study tracked 76 women with CPPDs over 14 weeks using mobile health technology, collecting more than 4,200 days’ worth of data. Participants reported their mental health, physical functioning, and pain levels weekly via an app (ehive), while Fitbit devices recorded their daily physical activity. The researchers used advanced statistical modeling to analyze how movement patterns influenced mental health outcomes over time.

One key finding was that the benefits appear to accumulate over time rather than provide immediate relief. “We were particularly intrigued to find that the positive effects of exercise seem to lag by a few days, meaning the mental health benefits may build up gradually,” says Dr. Ensari. “This insight is vital for both patients and health care providers, as it underscores the importance of consistency in physical activity.”

Beyond its implications for patient care, the study also highlights the growing role of artificial intelligence and mobile health technologies in chronic disease management.

“This study showcases the power of wearable technology and AI-driven analysis to uncover valuable insights about health and behavior in real time,” says Girish N. Nadkarni, MD, Chair of the Windreich Department of Artificial Intelligence and Human Healthat the Icahn School of Medicine, Director of the Hasso Plattner Institute for Digital Health, Irene and Dr. Arthur M. Fishberg Professor of Medicine, and Director of The Charles Bronfman Institute for Personalized Medicine. Dr. Nadkarni is also the inaugural System Chief of the Division of Data-Driven and Digital Medicine within Mount Sinai’s Department of Medicine and Co-Director of the Mount Sinai Clinical Intelligence Center. “By using innovative data modeling techniques, we can better understand how lifestyle factors like physical activity interact with health conditions and pave the way for more personalized treatment approaches.”

While the findings are encouraging, the researchers emphasize that physical activity should not be viewed as a replacement for medical treatment but rather as a complementary strategy. Future research will explore how different types and intensities of exercise impact mental health, pain, and fatigue, with the ultimate goal of developing personalized interventions using wearable technology and mobile apps.

The paper is titled “Trajectories of mHealth-tracked mental health and their predictors in female chronic pelvic pain disorders.”

The remaining authors, all with the Icahn School of Medicine except where indicated, are Emily L. Leventhal, BA: Nivedita Nukavarapu, PhD; Noemie Elhadad, PhD (Columbia University Irving Medical Center); Suzanne R. Bakken, PhD, RN, FAAN, FACMI, FIAHSI (Columbia University School of Nursing);  Michal A. Elovitz, MD;  Robert P. Hirten, MD;  Jovita Rodrigues, MS;  Matteo Danieletto, PhD; and Kyle Landell, BA.

Can physical activity extend the lifespans of older adults? A review article published in CMAJ (Canadian Medical Association Journal) summarizes the considerable evidence supporting the important role physical activity plays in preventing or reducing the effects of diseases and discusses how to prescribe effective exercise for older adults.

Canada’s population is aging, with at least 1 in 5 people aged 65 years or older in 2025, and the number of people older than age 85 years is expected to triple in the next 20 years. However, for many people, these added years do not mean healthy years. More than 80% of adults do not meet the recommendations for physical activity from the Canadian Physical Activity Guidelines.

“Physical activity is one of the most important ways to preserve or improve functional independence, including among older adults who are frail or deemed to be at increased risk of falling,” writes Dr. Jane Thornton, associate professor at Schulich School of Medicine & Dentistry, Western University, London, Ontario, and director of health, medicine and science at the International Olympic Committee. “Higher levels of physical activity in older age are associated with improvements in cognition, mental health, and quality of life.”

A 2023 meta-analysis of several large studies found that 150 minutes of moderate physical activity every week reduced risk of death from all causes by 31%. Physical activity is essential for aging well and can help prevent or reduce disease in more than 30 chronic conditions, such as coronary artery disease, heart failure, type 2 diabetes mellitus, chronic obstructive pulmonary disease, osteoporosis, depression, dementia, and cancer.

Benefits of activity include the following:

• Protection against risk of death from any cause
• Falls prevention through increased muscle strength and better balance
• Bone and joint health, including improved bone density and alleviation of some osteoarthritis symptoms
• Improved cognitive function, and better mood and mental health
• Ability to engage in daily activities and improved quality of life

The World Health Organization (WHO) recommends 150–300 minutes weekly of moderate-to-intense physical activity for adults, including older adults.

How can clinicians prescribe physical activity?

“As many older adults live with chronic health conditions or reduced mobility, clinicians should tailor and encourage them to take a gradual approach to increasing their physical activity, which should include resistance training (muscle strengthening) as an essential component,” said Dr. Samir Sinha, professor of medicine at the University of Toronto and director of health policy research, National Institute on Ageing.

The WHO 5-step framework — called the “5As” — can provide clinicians with a roadmap to promote activity in their patients. The authors also suggest inputting physical activity in patient records as a vital sign to follow over time. 

“Physical activity is underused as a health intervention both in the community and in the delivery of health care for older adults. Age, frailty, or existing functional impairments should not be viewed as absolute contraindications to physical activity but rather key reasons to prescribe it, considering the benefits of physical activity interventions for older adults. Older adults who become more physically active can potentially add years to their lives as well as higher quality of life to those years,” the authors conclude.

A study involving researchers at Murdoch University’s Health Futures Institute has revealed that moderate-intensity exercise can significantly influence appetite-related hormones and perceptions in males with obesity.

The study, titled “Acute effect of exercise on appetite-related factors in males with obesity,” provides new insights into how exercise can aid appetite control and weight management. 

One of the study authors, Associate Professor Timothy Fairchild from Murdoch’s School of Allied Health, said the study confirms their previous work showing the benefits of incorporating regular exercise into daily routines for individuals looking to manage their weight and improve their overall health. 

“People understand that exercise helps ‘burn energy’. A lot of people assume that exercise also increases hunger and energy intake afterwards,” Associate Professor Timothy Fairchild said.  

“We have previously shown, using high-intensity exercise, that this is not the case. 

“This latest study shows that even moderate-intensity exercise can have immediate and beneficial effects on appetite control in males with obesity.” 

The study not only assessed food intake and appetite, but also measured changes in hormones which help to regulate appetite.  

“Despite a strong focus on weight loss drugs in society at present, this study shows that lifestyle factors still have a strong and relevant role in helping people to live their healthiest life,” Associate Professor Fairchild said. 

“In fact, the hormones which have been shown to increase after exercise, are the same hormones which the most successful weight loss drugs are mimicking.”  

“The added benefit of exercise is that you also receive the additional physical and mental health benefits of exercise”.  

The full study Acute effect of exercise on appetite-related factors in males with obesity: A pilot study can be found in Physiological Reports journal.