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Babies born to women consuming a high fat, sugary diet at greater risk of cardiovascular disease and diabetes in later life
Consuming a high-fat, sugary diet during pregnancy also increases the likelihood of the unborn baby becoming insulin resistant in adulthood, potentially triggering diabetes and causing cardiovascular disease. This is despite babies being a normal weight at birth.
Babies born to pregnant women with obesity are more likely to develop heart problems and diabetes as adults due to fetal damage caused by the high-fat, high-energy diet of their mother.
That’s the groundbreaking finding from a new study published in the Journal of Physiology that shows for the first time that maternal obesity alters a critical thyroid hormone in the fetal heart, disrupting its development.
Consuming a high-fat, sugary diet during pregnancy also increases the likelihood of the unborn baby becoming insulin resistant in adulthood, potentially triggering diabetes and causing cardiovascular disease. This is despite babies being a normal weight at birth.
University of South Australia researchers identified the link by analysing tissue samples from the fetuses of pregnant baboons fed a high-fat, high-energy diet in a biomedical research institute in the United States. They then compared this to fetuses from baboons on a control diet.
Lead author, University of South Australia PhD candidate Melanie Bertossa, says the findings are significant because they demonstrate a clear link between an unhealthy diet high in saturated fats and sugar, and poor cardiovascular health.
“There has been a long-standing debate as to whether high-fat diets induce a hyper- or hypothyroid state in the fetal heart. Our evidence points to the latter,” Bertossa says.
“We found that a maternal high-fat, high-energy diet reduced concentrations of the active thyroid hormone T3, which acts like a switch around late gestation, telling the fetal heart to start preparing for life after birth. Without this signal, the fetal heart develops differently.”
Bertossa says that diets high in fat and sugar can alter the molecular pathways involved in insulin signalling and critical proteins involved in glucose uptake in the fetal heart. This increases the risk of cardiac insulin resistance, often leading to diabetes in adulthood.
“You’re born with all the heart cells you will ever have. The heart doesn’t make enough new heart muscle cells after birth to repair any damage, so changes that negatively impact these cells before birth could persist for a lifetime.
“These permanent changes could cause a further decline in heart health once children reach adolescence and adulthood when the heart starts to age.”
Senior author, UniSA Professor of Physiology Janna Morrison, says the study demonstrates the importance of good maternal nutrition in the leadup to pregnancy, not only for the mother’s sake but also for the health of the baby.
“Poor cardiac outcomes were seen in babies that had a normal birth weight – a sign that should guide future clinical practice,” Prof Morrison says.
“Cardiometabolic health screening should be performed on all babies born from these types of pregnancies, not just those born too small or too large, with the goal being to detect heart disease risks earlier.”
Prof Morrison says that if rising rates of high-fat sugary diets are not addressed, more people will develop health complications such as diabetes and cardiovascular disease, which could result in shorter life spans in the decades ahead.
“Hopefully, with the knowledge we have now about the negative health impacts of obesity, there is potential to change this trajectory.”
The researchers are currently undertaking long-term studies of babies born to women on high- fat high-energy diets to track their health over decades.
“Maternal high-fat high-energy diet alters metabolic factors in the non-human primate fetal heart” is published in the Journal of Physiology and authored by researchers from the University of South Australia, University of Wyoming and Texas Biomedical Health Institute.
NewsMakers
For weight loss, where food comes from may matter as much as how it is processed
Processed and ultra-processed animal foods tended to track with weight gain, and minimally processed plant foods with weight loss, although these associations were weaker. Ultra-processed plant foods were not associated with weight change.
Eating more meat, fish, eggs, and dairy products was associated with weight gain even when those foods were minimally processed, according to a study from the Physicians Committee for Responsible Medicine published in Nutrition Research. Minimally processed plant foods, such as fruits, vegetables, whole grains, and beans, showed the opposite pattern.
“Ultra-processed foods get most of the blame for weight gain, but our results suggest we also need to ask whether a food comes from a plant or an animal,” says lead author Hana Kahleova, MD, PhD, director of clinical research at the Physicians Committee. “A chicken breast is minimally processed. So is an apple. In our study, they did not move the scale in the same direction.”
The researchers analyzed data from a randomized crossover trial in which 62 adults with overweight followed a Mediterranean diet, rich in olive oil, fish, and nuts, and a low-fat vegan diet for 16 weeks each, separated by a four-week washout. Participants kept three-day diet records, and every food was classified by degree of processing, using the NOVA system, and by whether it came from a plant or an animal.
Compared with the Mediterranean diet, the vegan diet cut minimally processed animal foods by 135 grams per day more and raised minimally processed plant foods by 202 grams per day more. Processed animal and plant foods also fell more on the vegan diet. Across both diets, eating more minimally processed animal foods was linked to weight gain; this was the strongest association in the analysis and the only one to remain statistically significant after correction for multiple comparisons.
Processed and ultra-processed animal foods tended to track with weight gain, and minimally processed plant foods with weight loss, although these associations were weaker. Ultra-processed plant foods were not associated with weight change.
In the main trial, published in 2022, participants lost an average of 6 kilograms (about 13 pounds) on the vegan diet, with no change on the Mediterranean diet. Minimally processed plant foods are high in fiber and water and low in calorie density, which helps people feel full on fewer calories.
“If you want to lose weight, fill your plate with beans, vegetables, fruits, and whole grains, and leave the animal products off,” says Dr. Kahleova. “The degree of processing still matters, but it is not the whole story.”
NewsMakers
Mindfulness and self-compassion can alleviate premenstrual symptoms
It is estimated that PMS affects approximately 20-30% of menstruating people, while PMDD impacts 3-8%. The scale of the problem is significant, yet the psychological factors that protect against the development of these symptoms have not been thoroughly investigated.
A kind attitude toward oneself and practicing mindfulness can improve functioning in individuals who experience severe premenstrual symptoms, according to a study by psychologists from SWPS University and Jagiellonian University.
Premenstrual syndrome (PMS) and its more severe form, premenstrual dysphoric disorder (PMDD), cause distressing psychological and physical symptoms, including mood swings, fatigue, concentration difficulties, headaches, and muscle pain. These ailments occur during the second phase of the menstrual cycle and interfere with daily functioning, affecting education, work, relationships, and overall quality of life.
Up to 30 percent of women affected
It is estimated that PMS affects approximately 20-30% of menstruating people, while PMDD impacts 3-8%. The scale of the problem is significant, yet the psychological factors that protect against the development of these symptoms have not been thoroughly investigated.
The study, published in “Psychology and Psychotherapy: Theory, Research and Practice”, is part of a broader project analysing potential mechanisms and factors that may protect against the onset of PMS and PMDD. In a new study, Rachela Antosz-Rekucka, PhD, a psychologist at the Institute of Psychology at SWPS University, and Katarzyna Prochwicz, PhD, a professor at the Institute of Psychology of the Jagiellonian University, analysed factors that might protect against the onset of severe premenstrual symptoms. They examined variables such as the sense of coherence, mindfulness skills, and self-compassion, and investigated their relationship with past trauma, perceived stress levels, and symptoms of premenstrual disorders.
The study involved 228 participants aged 18 to 52. They were asked about their past experiences with premenstrual symptoms, and a part of the group subsequently tracked their symptoms over the course of two menstrual cycles.
Self-compassion and mindfulness help alleviate symptoms
The results suggest that higher levels of certain psychological resources can moderate the negative effect of stress and trauma on the severity of menstrual cycle-related symptoms.
Specific psychological attitudes may noticeably reduce the impact of daily stress on the severity of premenstrual symptoms. These include a kind attitude toward oneself and the acceptance of difficult moments, known as self-compassion. This approach helps women to navigate the challenging phases of their cycle more easily, even during times of intense nervous tension, says Rachela Antosz-Rekucka of SWPS University, who conducted the study as part of her doctoral research at the Jagiellonian University.
Practicing mindfulness (directing one’s attention to the present moment without judgment or worry) can also offer relief. In the context of PMS and PMDD, refraining from judging one’s own emotional reactions is particularly helpful, as it prevents the magnification of perceived discomfort. Furthermore, individuals with a strong sense of coherence cope better with rising premenstrual stress.
Past trauma and premenstrual symptoms
For individuals with a history of trauma, the ability to precisely describe their internal states and feelings, combined with the capacity to avoid judging their own emotional reactions, can help mitigate the negative impact of that trauma on premenstrual symptoms.
Psychological resources boost stress resilience
The results of the study could be significant for many people who menstruate. These findings could pave the way for modern therapeutic programs based on approaches such as mindfulness training or self-compassion-focused therapy, potentially reducing the reliance on medication.
The study suggests that more understanding, mindful, and compassionate attitude towards oneself may benefit individuals with severe premenstrual symptoms. PMS and PMDD are chronic conditions, which is why interventions such as mindfulness-based therapy, compassion-focused therapy, or strategies oriented at enhancing the sense of coherence, may help individuals navigate their conditions more effectively, and possibly increase their overall quality of life, Rachela Antosz-Rekucka emphasises.
NewsMakers
Music can enhance the flavor of your food
The brain does not create flavor based solely on signals from the tongue.
The moment we take a sip of our morning coffee or our first bite of lunch, the brain begins interpreting what we taste. Is it sweet? Sour? Or something else entirely?
But the brain does not create flavor based solely on signals from the tongue. That is the finding of a new study from the Department of Food Science, published in the scientific journal Scientific Reports.
“When music reaches the ears at the same time as we are eating, we can see that the brain responds more strongly than when taste is experienced without music,” says first author and postdoctoral researcher Alberte Baggesgaard Seeberg from the Department of Food Science.
Using brain scans, the researchers show that music can activate some of the same brain regions involved in processing taste.
“This tells us that flavour is not simply a property of food. Flavor is an experience created by the brain,” says senior author and associate professor Janice Wang.
A breakthrough in brain imaging
This is the first time researchers have used brain imaging to show what happens in the brain when it processes taste. In the study, they used functional magnetic resonance imaging (fMRI), which measures activity in different parts of the brain by detecting changes in blood flow.
“This allows us to move beyond simply asking people about their experiences, which has been the approach in previous studies. With brain scans, we gain a biological window into what happens when the senses interact,” says Alberte Baggesgaard Seeberg.
While participants lay in the scanner, their brain activity was measured under different conditions. In some cases, they listened only to music. In others, they tasted flavor solutions. In some trials, music and taste were presented simultaneously. This enabled the researchers to compare how the brain responds to sound and taste separately and in combination.
The results clearly showed that certain brain regions were more active when participants listened to music while tasting one of the two flavor solutions.
“We can see that flavor is constructed by the brain and not only by the taste buds. What determines flavor is not limited to what happens on the tongue. It emerges through the integration of multiple senses,” says Janice Wang.
The findings build on previous studies showing that music can enhance particular taste perceptions. For example, slow pop music with harmonious tones may enhance sweetness. Until now, however, this has only been investigated through behavioral studies in which participants rated flavours with and without music.
Shaping flavor experiences could improve wellbeing
According to the researchers, the new knowledge could be used to design better eating experiences in a range of settings, including restaurants, canteens and hospitals.
“For people who are at risk of malnutrition, something as simple as music could potentially improve the eating experience. There is a great deal we can do, often at very little cost, to improve quality of life for some people,” says Alberte Baggesgaard Seeberg.
Janice Wang is pleased that, after many years of research into flavour and sensory perception, the team can now present biological evidence of how the senses interact.
“We now have a new way of influencing flavor perception, creating a better meal experience and potentially a better overall experience, without necessarily changing the food itself,” she says.
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