Connect with us

NewsMakers

Potential improvement in Type 2 diabetes treatment discovered – Monash University research finds

Dr. Vincent Marion, the Inserm study coordinator, and deputy director at the Laboratory of Medical Genetics in Strasbourg, France, along with his team, designed the breakthrough peptide drug PATAS and has shown that it was able to fix this problem by enabling glucose to be used in fat cells.

Published

on

Monash University together with a team of international researchers decoded what causes insulin resistance in fat tissue cells which has been a major stumbling block in treating and preventing type 2 diabetes. This research gave birth to the development of PATAS, a new drug that ‘reboots’ how fat cells use insulin to revolutionize type 2 diabetes treatment and improve the outlook of hundreds of millions of patients globally.

Dr. Vincent Marion, the Inserm study coordinator, and deputy director at the Laboratory of Medical Genetics in Strasbourg, France, along with his team, designed the breakthrough peptide drug PATAS and has shown that it was able to fix this problem by enabling glucose to be used in fat cells.

PATAS, which is being developed by AdipoPharma, could be delivered by simple injection and possibly a patch. It may also have the potential to prevent type 2 diabetes, a major global epidemic, largely driven by obesity.

Co-researcher Paul Zimmet AO, Professor of Diabetes at Monash University, said the discovery could improve metabolic control of diabetes and reduce the risk of the serious complications of diabetes including heart, kidney, liver, and eye disease.

PATAS corrects an abnormality in fat cells by separating two proteins, ALMS1 and PKC alpha, that are associated with insulin resistance by blocking insulin from initiating glucose uptake.

In rodent studies, PATAS reduced insulin resistance, glucose intolerance, and fat buildup in the liver (steatosis). Beneficial effects were also observed in glucose-intolerant animal models. Similarly, when used on cultured human fat cells in the laboratory and independent contract research organizations, the drug reactivated glucose uptake in the fat cells.

Risks of Diabetes in the Philippines

The International Diabetes Federation is alarmed by the rapid increase of adults diagnosed with diabetes in the country and it is expected to further rise to 5.4 million by 2030 and 7.5 million by 2045.[1] Diabetes is currently the fourth leading cause of mortality in the Philippines. According to a report by the Philippine Statistics Authority released last January 2023,  26,774 deaths due to diabetes mellitus have been recorded in the previous year.

Aside from lifestyle changes and medications, the Department of Health continues to develop and evaluate add-on treatments for people with diabetes mellitus, such as prescribing Dapagliflozin to diabetic patients and those at high risk of cardiovascular disease and/or diabetic neuropathy.[2]

Diabetes Medication Breakthrough

The diabetes study breakthrough emerged following research into Alstrom Syndrome, an ultra-rare genetic disease in children. It is associated with obesity and severe insulin resistance that leads to type 2 diabetes and an accelerated form of liver steatosis and fibrosis. The researchers found that insulin resistance was linked to the dysfunctional protein, ALMS1.

Building on this previous research, the multinational team next discovered that in normal fat cells and upon insulin signaling, a protein called PKC alpha is released from ALMS1 to trigger glucose uptake. With insulin resistance, PKC alpha is no longer released from ALMS1 and hence glucose is no longer absorbed by the fat cells to be utilized.

Dr. Marion shared that in cultured human adipocytes as well as in most relevant animal models, PATAS was able to separate the proteins and restore normal function of glucose uptake and utilization in the fat cells.

This research study has for the first time, identified the root cause of insulin resistance in adipocytes, a precursor of type 2 diabetes, and developed a drug that reduces insulin resistance and restores normal glucose uptake.

Professor Zimmet said the discovery was potentially one of the most important he had seen in his 45 years of diabetes research. “This is a very exciting discovery that could have enormous health benefits, not just for people with type 2 diabetes, but also for patients with other chronic medical disorders caused by insulin resistance including cardiac diseases, and fatty liver and the Metabolic Syndrome,” Professor Zimmet added.

The research was led by Inserm, France’s National Institute of Health and Medical Research, in collaboration with the University of Birmingham (UK) and Monash University. Human clinical trials are likely to start within 2023.

Zest Magazine accepts contributions promoting everything about living the good life (and how to make this so). C'mon, give us a yell.

NewsMakers

USANA Philippines celebrates 15-year anniversary

Beyond awards, the community it empowers is the true measure of success. From employees to Associates, life-changing opportunities allow them to grow both personally and professionally.

Published

on

USANA Philippines recently celebrated its 15-year anniversary in it its ongoing mission to maintain wellness. Company executives, ambassadors, Associates, and product users all attended this grand celebration — a testament to the unwavering commitment to reach one million families worldwide.  

Since its launch in 2009, USANA Philippines has received numerous accolades: Named among the best companies to work for in the country by the HR Asia Awards; Winning the prestigious Linchpin Award from the Asia Pacific Enterprise Awards (APEA); Recognized by Euromonitor as the Number 1 Vitamins and Dietary Supplements Brand in the Philippines for five consecutive years. 

But beyond awards, the community it empowers is the true measure of success. From employees to Associates, life-changing opportunities allow them to grow both personally and professionally.

When Analan Omambing, assistant customer service manager, joined USANA she was shy and introverted, but the support she’s received has pushed her to step up as a team leader.  “The career growth and personal development I gained here have transformed my personality significantly,” she says.  

USANA Philippines also creates ways to form meaningful relationships.  

“Direct selling, especially USANA, is all about relationships,” says Aurora Gaston, vice president for sales development.   

As the first employee hired by USANA Philippines, Loudelle Cinco, USANA’s regional controller in the Philippines, Thailand, and Indonesia has experienced it all.  

“One of the things I treasure is the friendship, having a family in USANA. This position has paved the way to building great and lasting relationships.”  

Over the past 15 years, USANA has seen a shift in their Associate’s perspectives — from a focus on individual success to embracing a more collaborative and inclusive view of the community.  

“This comprehensive development approach underscores USANA’s commitment to not only enhance the lives of our Associates but also empower them to make a meaningful difference in the world” shared Cherry Dionisio-Ampig, general manager for USANA Philippines.  

USANA consistently strives to make an impact by being responsive to shifts in consumer behavior. Changes made over the years include strengthening the brand through collaboration, embracing the evolution of social media, and ensuring Associates can effortlessly introduce USANA’s products to the world. And as USANA Philippines celebrates this milestone, its vigor to sustain wins and touch more lives grows even stronger.  

“We are dedicated to ongoing research and innovation to develop products that not only meet — but exceed — the expectations of families worldwide. By focusing on efficacy and quality, we aim to be the trusted partner in every family’s journey towards maintaining wellness” Cherry says.   

The 15-Year “Ignite the Vibe” celebration was held at the Marriot Hotel Grand Ballroom. It’s the final touch to the anniversary festivities that kicked off with a Thanksgiving Day event in January.

Continue Reading

NewsMakers

Independence Day at Ortigas Malls celebrates Filipino heroes, culture, music

On June 12, GH Mall, Tiendesitas, and Estancia will kick off their Independence Day celebrations in exciting ways, and shoppers shouldn’t miss them.

Published

on

Independence Day (Araw ng Kalayaan) is a celebration of historical and modern heroes who have fought for Filipinos’ freedom. As we welcome the annual holiday, Ortigas Malls has prepared a series of events and activities that highlight our history and colorful culture.

On June 12, GH Mall, Tiendesitas, and Estancia will kick off their Independence Day celebrations in exciting ways, and shoppers shouldn’t miss them:

Greenhills

Starting at 10am, GH Mall will hold a Pagtaas ng Watawat (flag-raising ceremony) at the East Wing Atrium of GH Mall. A Marching Band will also energize shoppers at 12pm.

From 3pm to 6pm, there will be an entertaining and educational Likhang Sining at Kalayaan presentation by the Tanghalang Tula, Kundiman at Katutubong Sayaw. This wonderful display of talent will highlight our beloved Filipino culture through different facets of art.

Shoppers can also marvel at the extraordinary Philippine flag display at GH Mall made out of 1,400 origami flowers courtesy of Origami Philippines. The origami flowers symbolize the enduring bonds and deep-rooted friendships that define Filipino culture. Feel free to take photos in front of the display and share it on social media!

Tiendesitas

Known for being a home of local goods and handicrafts, Tiendesitas is celebrating Independence Day with a whole day of musical performances. Start the day off with a heart-thumping Marching Band performance at Level 1, Food Village from 10am to 11:30am. Musika’t Kalayaan at Level 2, Food Village will delight shoppers with Filipino tunes from 3pm to 9pm.

Estancia

Estancia Mall will also showcase local music for its Independence Day celebration. From 10am to 7pm, shoppers can sing and dance to their favorite P-pop songs at the P-Pop Music Fest: Hiraya at 2/F East Wing. They can also catch the Independence Day Marching Band performance on the ground floor of the East Wing from 11am to 12pm. 

Continue Reading

NewsMakers

Red Bull Dance Your Style returns

The winners of each qualifier will advance to the National Finals, happening on September7. The winning finalist will proudly represent the Philippines in the upcoming Red Bull Dance Your Style World Finals in India, scheduled for November 9, 2024.

Published

on

Red Bull Dance Your Style, the  global 1-on-1 street dance competition renowned for its emphasis on freestyle and improvisational skills among dancers, is returning to the Philippines for its third consecutive year.

Following its highly successful previous editions, Red Bull Dance Your Style is back to ignite the streets of the Philippines with even more explosive battles, spotlighting the incredible talents of the country’s top dancers. Each round of the competition will challenge dancers to show off their talent and creativity as they battle it out to a random selection of songs, ranging from iconic classics to contemporary dance hits.

What sets this electrifying dance competition apart is its unique battle format, where the audience holds the power to crown the victor. This distinct setup fuels the atmosphere, empowering dancers to unleash their full potential and captivate the audience with every move.

Red Bull Dance Your Style Year 3: Spreading the Beat Across the Nation

Red Bull Dance Your Style’s much-awaited comeback is taking the battle beyond the streets of Manila to every corner of the archipelago. The competition is open to Philippine residents, aged 18 years and above, who exhibit exceptional skill, dedication, and passion for street dancing. The quest to find the next wave of top Philippine dance talents will reach four major cities: Baguio, Manila, Davao, and Cebu, culminating in the qualifiers in Davao (June 29), Cebu (July 13), and Manila (July 27).

“We are so excited to have the third edition of Red Bull Dance Your Style in the Philippines,” said Philippine All-Stars legend Lema Diaz, who is returning as this year’s dance consultant. “It’s definitely gonna be bigger and better this year!”

Diaz shared that Red Bull Dance Your Style has expanded its search for the top Filipino dance talents for its third year in the Philippines. “This year, we have included North Luzon (Baguio) and Mindanao (Davao) in the mix for our search for the dancer who has charisma, skills, and passion,” explained Diaz. “Expect a tougher competition this year.”

She added, “Since its first edition, Red Bull Dance Your Style has brought the dance community closer and we have grown a lot stronger. It has been an avenue to come together and collaborate, learn from each other, and inspire one another. Every year is a chance for us to keep that momentum and witness greatness from our local dance community.”

Diaz offered her expert advice to this year’s aspiring dancers saying, “It’s important to show your dance, be you. Be confident and embrace your strength. Be prepared to perform for the crowd, they will be rooting for you. Don’t forget to have a lot of fun!”

The winners of each qualifier will advance to the National Finals, happening on September7. The winning finalist will proudly represent the Philippines in the upcoming Red Bull Dance Your Style World Finals in India, scheduled for November 9, 2024.

Follow the Red Bull Dance Your Style journey and stay tuned for more details about the upcoming auditions. Don’t miss out on the chance to be part of Red Bull Dance Your Style Philippines. See you on the streets!

For more information and updates regarding this year’s season of Red Bull Dance Your Style, visit the official Red Bull website and the following social media pages (Facebook | Twitter | Instagram | Tiktok )

Continue Reading
Advertisement
Advertisement

Like Us On Facebook

Facebook Pagelike Widget

Most Popular

Copyright ©FRINGE PUBLISHING. All rights reserved.