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Further evidence that vitamin D might protect against severe COVID-19 disease and death

Researchers found that ambient UVB radiation at an individual’s place of residence preceding COVID-19 infection was strongly and inversely associated with hospitalisation and death. This suggests that vitamin D may protect against severe COVID-19 disease and death.

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New research from Trinity College Dublin and University of Edinburgh has examined the association between vitamin D and COVID-19, and found that ambient ultraviolet B (UVB) radiation (which is key for vitamin D production in the skin) at an individual’s place of residence in the weeks before COVID-19 infection, was strongly protective against severe disease and death. The paper has been published in the journal Scientific Reports.

Previous studies have linked vitamin D deficiency with an increased susceptibility to viral and bacterial respiratory infections. Similarly, several observational studies found a strong correlation between vitamin D deficiency and COVID-19, but it could be that these effects are confounded and in fact a result of other factors, such as obesity, older age or chronic illness which are also linked with low vitamin D.

To overcome this, researchers were able to calculate “genetically-predicted” vitamin D level, that is not confounded by other demographic, health and lifestyle factors, by using the information from over one hundred genes that determine vitamin D status.

The Mendelian Randomization is a particular analytical approach that enabled researchers to investigate whether vitamin D and COVID-19 might be causally linked using genetic data. Few earlier studies attempted this but failed to show a causal link. This could be because UVB radiation sunshine which is the most important source of vitamin D for majority of people was ignored.

Researchers, for the first time, looked jointly at genetically-predicted and UVB-predicted vitamin D level. Almost half a million individuals in the UK took part in the study, and ambient UVB radiation before COVID-19 infection was individually assessed for each participant. When comparing the two variables, researchers found that correlation with measured vitamin D concentration in the circulation was three-fold stronger for UVB-predicted vitamin D level, compared to genetically-predicted.

Researchers found that ambient UVB radiation at an individual’s place of residence preceding COVID-19 infection was strongly and inversely associated with hospitalisation and death. This suggests that vitamin D may protect against severe COVID-19 disease and death. Additionally, while the results from the Mendelian Randomization analysis weren’t conclusive, some indication of a potential causal effect was noted. Because of the relatively weak link between genetically-predicted vitamin D level that is used for Mendelian Randomization analysis, it is possible that the number of cases in the current study was too small to convincingly determine causal effect, but future larger studies might provide the answer.

Professor Lina Zgaga, Associate Professor in Epidemiology, School of Medicine, Trinity College and senior researcher on the study said: “Our study adds further evidence that vitamin D might protect against severe COVID-19 infection. Conducting a properly designed COVID-19 randomized controlled trial of vitamin D supplementation is critical. Until then, given that vitamin D supplements are safe and cheap, it is definitely advisable to take supplements and protect against vitamin D deficiency, particularly with winter on the horizon.”

Professor Evropi Theodoratou, Professor of Cancer Epidemiology and Global Health, University of Edinburgh and senior researcher on the study said: “Given the lack of highly effective therapies against COVID-19, we think it is important to remain open-minded to emerging results from rigorously conducted studies of vitamin D.”

Dr Xue Li, a researcher on the study from Zhejiang University said: “Our study supports the recommendation of vitamin D supplementation for not only the maintenance of bone and muscle health during the lock down, but also the potential benefits in relation to protection from COVID-19.”

The full paper: An observational and Mendelian randomization study on vitamin D and COVID-19 risk in UK Biobank can be read here: https://www.nature.com/articles/s41598-021-97679-5.

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Young people who vape more likely to report chronic stress

Young people who use e-cigarettes had poorer quality of life but lower risks of some signs of ill health, such as high blood pressure, although these findings did not reach statistical significance.

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Young people who have used e-cigarettes are more than twice as likely to report experiencing chronic stress, according to a study by Dr Teresa To, a senior scientist at The Hospital for Sick Children (SickKids) in Toronto, Canada.

She said: “Research is starting to show how vaping affects young people’s physical and mental health. For example, our previous research has shown that those who vape are more likely to suffer an asthma attack. In this study we were particularly interested in the relationship between vaping, mental health and quality of life among young people.”

The researchers used data from the Canadian Health Measures Surveys, a national survey designed to represent the Canadian population. It included 905 people aged between 15 and 30 years, of which 115 (12.7%) said they had used e-cigarettes.

The data showed that although young people who vaped were more likely to be physically active, they were also more likely to report experiencing extreme chronic stress in their lives.

Dr To said: “Chronic stress can lead to mental health conditions such as anxiety and depression. It’s important for young people experiencing chronic stress to be given support early on to help them avoid resorting to unhealthy coping mechanisms like vaping or smoking. Vaping is not an effective way to cope with stress, but stress and anxiety can trigger vape cravings, and make it harder for a user to quit.”

The researchers point out that while their study shows a link between vaping and stress in young people, it does not show whether stress caused an increase in vaping, or whether vaping increased experiences of stress, or if another factor led to an increase in both. However, their research did take into account other factors that are known to influence stress, such as income, alcohol consumption and health conditions like asthma and diabetes.

Dr To added: “We do not know why young people using e-cigarettes tend to be more physically active, but it could be that they are trying to control their weight with exercise and believe vaping could help.”

The results also indicated that young people who use e-cigarettes had poorer quality of life but lower risks of some signs of ill health, such as high blood pressure, although these findings did not reach statistical significance.

“At the time of the study, this group of young people had good physical health overall; however, we need to study the effects of e-cigarettes in the longer term to understand their impact on young people’s health. We know that stress induces oxidative stress and inflammation in the body and these play an important role in the risk of developing chronic conditions such as asthma, diabetes and cardiovascular disease,” Dr To added.

Professor Elif Dağlı, who is chair of the European Respiratory Society’s group on Tobacco, smoking control and health education, and was not involved in the research, said: “This study suggests a link between vaping and stress among young people, and it adds to what we already know about the effects of vaping on young people’s health. Vaping is still relatively new, but the numbers of children and young people using e-cigarettes are rising rapidly. We need more research on the impacts of vaping, but we also need to raise awareness of the harms of using e-cigarettes and provide support to help young people avoid or quit vaping.

“This is one of several studies about the effects of vaping that are being presented at the European Respiratory Society International Congress. In particular, we will be examining the influence of favoured e-cigarettes and looking for ways to end the epidemic of vaping among children and adolescents.”

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Blackbough leads environmental awareness campaign with locals

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In the picturesque paradise of Siargao Island, Jemina Ty, the creative force behind the globally celebrated swimwear brand Blackbough, takes the helm as the leader spearheading a sustainability campaign, hand in hand with the local community.

With its pristine islands, stunning white sand beaches, and sprawling coconut fields, Siargao Island has captivated beach-lovers and adventure-seekers from all over the world. However, this idyllic destination in the southeastern region of the Philippines is facing threats due to plastic pollution and environmental degradation. In response, Blackbough recently organized a beach cleanup campaign to protect Siargao Island and raise awareness among locals and tourists alike.

Ty pointed out, “By 2050, there’s a good chance that we’ll see more plastic in the ocean than fish. That’s why through this initiative, we hope to create a chain reaction and encourage people to be more mindful of their actions and to make choices that nurture the environment.”

The Blackbough Swim Team led by Chief Executive Officer and Founder Jemina Ty accumulated a total of 100 sacks of plastic waste and debris during their coastal clean-up activity at Malinao Beach, General Luna, Siargao.

Under Ty’s leadership, Blackbough became a widely followed international swimwear brand with a heart for sustainability. The company is committed to reducing its environmental footprint by using recycled nylon, investing in ethical factories, repurposing scrap fabrics to accessories, and incorporating recyclable and reusable packaging options. By offering stylish and eco-friendly swimwear, Blackbough encourages customers to make more sustainable choices.

“At Blackbough, we believe that every journey towards sustainability begins with a single step. Leveraging Blackbough’s global presence, we aim to showcase the beauty of our Philippine islands and the importance of taking care of them.” 

The beach cleanup event took place at Malinao Beach, General Luna drawing over a hundred volunteers from diverse backgrounds, including tourists, locals, and stakeholders. Their collective effort resulted in the removal of 100 sacks of plastic waste and debris, offering participants a firsthand perspective on the detrimental effects of pollution on the island.

The Blackbough team, composed of young, creative, and passionate individuals who champion various causes such as marine life conservation and environmental preservation, includes team members based on Siargao Island. Ty acknowledged their commitment, saying, “Siargao is not just a location for us; it’s also home to many of our amazing team members. I recognize that it’s my responsibility to contribute positively to the communities and societies where we operate.”

Beyond cleaning up the beach, Blackbough’s campaign is a call to arms for travelers, environmental enthusiasts, and conscious consumers to begin their sustainability journey. Siargao Island is just the starting point for Blackbough’s beach cleanup initiatives, marking the launch of their Clean Beach Campaign, a series of beach cleanup activities in collaboration with various local communities across the Philippine islands as part of Blackbough’s advocacy for sustainability and environmental protection.

Ty believes in being proactive when it comes to addressing environmental issues. Ty emphasized, “I think that we should not wait for our beaches to reach a critical level of degradation before we act. We hope for everyone’s support as we pursue our mission to protect the country’s beaches. Together, we can make a lasting impact and inspire others to join us on this journey.”

As part of its journey towards sustainability, Blackbough has launched a fundraising drive dubbed “Donate to Clean our Coasts” on its website’s checkout page, running until mid-October. One hundred percent of the proceeds raised through this campaign will be dedicated to supporting the International Coastal Cleanup Philippines, a non-profit volunteer organization dedicated to cleaning up marine debris and promoting ocean conservation. Blackbough has also pledged to match the cumulative donations made during the month of September.

To learn more about Blackbough’s fundraising initiative, please visit https://blackboughswim.com/pages/our-commitment.

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All work and no play will really make a dull life – research

‘Achievement’ and ‘conformity’ values had no impact on happiness whatsoever. However, the researchers believe achievement could impact on happiness when linked to job satisfaction or the amount of days worked.

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A study across three countries led by the Department of Psychology’s Dr Paul Hanel discovered people who prioritised achievement over enjoyment were less happy on the next day. Whereas those who aimed for freedom said they had a 13% increase in well-being, recording better sleep quality and life satisfaction. And participants who tried to relax and follow their hobbies recorded an average well-being boost of 8% and a 10% drop in stress and anxiety.

Dr Hanel worked with colleagues at the University of Bath on the Journal of Personality-published study. For the first time, it explored how following various values impacts our happiness.

Dr Hanel said: “We all know the old saying ‘All work and no play makes Jack a dull boy’ and this study shows it might actually be true. There is no benefit to well-being in prioritising achievement over fun and autonomy. This research shows that there are real benefits to having a balanced life and taking time to focus on enjoying ourselves and following individual goals. Ironically by doing this, people could in fact be more successful as they will be more relaxed, happier and satisfied.”

The study –Value Fulfilment and Well-being: Clarifying Directions Over Time – examined more than 180 people in India, Turkey and the UK. They filled in a diary across nine days and recorded how following different values affected them.

Interestingly all nationalities reported the same results with the following of ‘hedonism’ and ‘self-direction’ values leading to increased happiness. ‘Achievement’ and ‘conformity’ values had no impact on happiness whatsoever. However, the researchers believe achievement could impact on happiness when linked to job satisfaction or the amount of days worked.

Professor Greg Maio, University of Bath, said: “This multination project was an exciting foray into questions about how values affect well-being in day-to-day life. People often spend most of their days working hard for their daily income, studies, and careers. Against this backdrop, where achievement-oriented values have ring-fenced a great portion of our time, we found that it helps to value freedom and other values just enough to bring in balance and recovery.”

In the future, it will be interesting to consider how this pattern interacts with relevant traits, such as conscientiousness, and situational contexts, such as type of employment, Maio added.

It is hoped the research will now influence mental health provision and influence therapeutic give to clients.

Dr Hanel added: “Our research further shows that it might be more important to focus on increasing happiness rather than reducing anxiety and stress, which is of course also important, just not as much.”

The study was published in collaboration with Hamdullah Tunç, Divija Bhasin, and Dr Lukas Litzellachner.

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