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AstraZeneca’s Dapagliflozin now approved to treat adult patients with heart failure in Phl

Dapagliflozin, a medicine developed by British-Swedish pharmaceutical company AstraZeneca, is now approved in the Philippines for the treatment of adult patients suffering from heart failure.

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Dapagliflozin, a medicine developed by British-Swedish pharmaceutical company AstraZeneca, is now approved in the Philippines for the treatment of adult patients suffering from heart failure with reduced ejection fraction (HFrEF) to reduce the need for hospitalization and risk of mortality.

With the approval, Dapagliflozin is the first and only drug under the sodium glucose transport protein 2 inhibitor (SGLT2i) class approved to treat heart failure in adult patients with reduced ejection fraction. It is the only SGLT2i proven to significantly prevent cardiovascular death and death due to other causes in these heart failure patients.

In a virtual discussion hosted by AstraZeneca Philippines, experts from the Philippines and around the world talked about the latest medical development and treatment for heart failure.

According to Dr. Erlyn Demerre, chair of Heart Failure Program at St. Luke’s Medical Center in Quezon City, heart failure is dominating the cardiovascular landscape not just in the Philippines but globally. It is considered a global pandemic affecting a lot of people worldwide and it is increasing in prevalence.

Global data show that the overall known prevalence rate of heart failure is three to 20 patients per 1,000 population although this exceeds a 100 per 1,000 in those age 65 years and over. The annual incidence of heart failure is one to five per 1,000 and the relative incidence doubles for each decade of life after the age of 45, and that in one in three die within a year and one out of four are re-admitted in a hospital in 30 days with much morbidity and poor quality of life.

“It is still an ongoing pandemic. Much work has been put into the study of heart failure and we are definitely on a better position in the diagnosis and management of heart failure now. But, ironically, despite medical management and significant advance in therapies and prevention, heart failure is still a major and increasing burden all over the world with high mortality and morbidity and poor quality of life,” said Demerre.  

Lotis Ramin, country president at AstraZeneca Philippines, relayed that nine out of 10 patients are symptomatic even with current heart failure standard of care (SoC), and nearly one-third or one out of three patients suffering from heart failure with reduced ejection fraction are at risk of hospitalization which increases the risk of mortality.

Professor David Sim, president of the Heart Failure Society in Singapore, noted that nine million people in Southeast Asia have heart failure with an overall 15% mortality rate. However, pharmacological options for heart failure have increased over the last decade and guideline-directed heart failure pharmacotherapy cumulatively reduced mortality by 76%. 

Sim emphasized that “the approval of Dapagliflozin for the treatment of HFrEF in the Philippines is a major step forward in the battle against the disease burden of heart failure. Together with the current standard of care, Dapagliflozin will contribute further to a lower mortality, less hear failure hospitalization and importantly a better quality of life for patients suffering from heart failure.”

In his presentation on Dapagliflozin and Prevention of Adverse-outcomes in Heart Failure Trial (DAPA HF) Trial: A New Era in Heart Failure Management, Professor Piotor Ponikowski of the Heart Failure Association of the European Society of Cardiology cited that “heart failure is becoming a preventable and treatable diseases, with medication that allows patients to live longer and live better outside of hospital.”

It is the first outcomes trial with an SGLT2 inhibitor investigating the treatment of HFrEF. The results showed a reduction of 26% in the occurrence of cardiovascular death, hospitalization for heart failure (hHF) and Urgent Hospital Visit for heart failure along with a 30% reduction in hHF. Dapagliflozin’s significant 18% reduction in cardiovascular death and 17% reduction on death due to other causes which were only seen in the DAPA HF study.

“Dapagliflozin has the ability to reduce mortality, prevent hospital admission, improve clinical status, functional capacity, and quality of life,” said Ponikowski.

With the confirmation of Dapagliflozin as a medication to treat adult persons suffering from heart failure with reduced ejection fraction, Ramin said “we hope this development and Dapagliflozin life-saving efficacy can transform the heart failure standard of care.”

REYNALDO “Rey” R. VICENTE’s career experience involves mostly research in publishing companies. He previously held the position of Research and Events Director of Media G8way Corp., publisher of Computerworld Philippines (CWP), PC World Philippines, and IT Resource. He also handled events organized for CWP. Prior to this, he was a Research Head of a business publication. Now as co-publisher of Zest Magazine, Rey also serves as Managing Editor. Rey finished his bachelor’s degree majoring in Economics at the University of Santo Tomas.

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Embrace life every moment at Two Botanika Nature Residences

Two Botanika offers a “lanai” living experience with deep balconies, inspired by a design feature seen in tropical countries, allowing better airflow and spacious living. It promises world-class luxury living spaces with 70% of the whole development dedicated to open spaces. Families and individuals also get convenient access to business and lifestyle hubs in the south for work and leisure. But there’s more that residents can look forward to.

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Imagine a quiet morning with a gentle breeze while sipping a cup of coffee. A panoramic view of lush green surroundings greets you as you wait for the sunrise. It’s the kind of life that welcomes the future occupants of the recently unveiled 1-bedroom, east-facing units at Two Botanika Nature Residences.

Two Botanika offers a “lanai” living experience with deep balconies, inspired by a design feature seen in tropical countries, allowing better airflow and spacious living. It promises world-class luxury living spaces with 70% of the whole development dedicated to open spaces. Families and individuals also get convenient access to business and lifestyle hubs in the south for work and leisure. But there’s more that residents can look forward to.

In celebration of its unveiling, an exclusive event was held at the Filigree Showsuites, styled by celebrity event stylist Robert Blancaflor, with performances by the Manila Philharmonic Orchestra. 

“We are happy to announce through this event that the east-facing 1-bedroom units at Two Botanika are now open. Mornings will be something to look forward to because the first thing residents would see are the sunrise and a beautiful view — the life they deserve,” said Daphne Sanchez, head of Filigree, the brand portfolio behind the residential masterpieces in Metro Manila and Metro Clark.

Redefining luxury with space

In charge of Two Botanika’s efficient unit space planning is New York-trained, Tina Periquet from Periquet Galicia Inc. To further upscale the lifestyle of future residents, the firm meticulously designed every space so its use can be maximized. The units are designed in a curved, well-defined shape to make residents feel safe in their sanctuary. Outside their home, the surrounding is peaceful and safe, giving residents the freedom to wander around without worries. 

Tina Periquet shared, “My ultimate task is to curate experiences in the home. So, [I designed Two Botanika in a way that] there is a nice sense of community and it’s really very much in keeping with the overall idea of being in a healthful place where you can just relax and not feel confined the way you normally would in a condo tower. There is a sense of expansiveness, openness, actual ventilation, and daylight.”

The newly-opened 1-bedroom units are 70–76 sq m in size, much bigger than the average 35–55 sq m 1-bedroom units from other properties. These sizeable abodes of Two Botanika allow residents to move around comfortably in a large space.

Experience a life of luxury in your own sanctuary

Beyond the spacious unit, residents can experience convenience and an elevated lifestyle with the amenities offered. There’s no need to go out of town for a quick dip in a swimming pool surrounded by nature as Two Botanika has tiered swimming pools and a sunbathing deck residents can use. Amenities can be found across all three towers, accessible to all residents. Residents can enjoy all of these while fostering a sense of community with the other residents. Parents can have fun and create core memories with their kids in the indoor play area and game room.

Residents can live an active lifestyle without leaving the property with its outdoor play area and a fully-fitted gym. If they want to unwind, residents can enjoy the peace and quiet while admiring the scenic view from the Line Garden, or strike up a conversation with others in the sky lounge, greenhouse, or lawn space.

For residents looking to socialize and are already members of The Palms Country Club — an accredited member club of the prestigious International Associate Clubs, Two Botanika has a gate exclusive to its residents who are members of the club, a few steps away from their unit. Residents who are members can experience an elevated lifestyle in the club. They can dine, unwind, relax, or celebrate special moments with their loved ones at The Palms Country Club.

Every waking moment opens a plethora of exciting possibilities for Two Botanika residents. Two Botanika offers a huge living space for them to comfortably lounge in and amenities where they can unwind and create more precious memories whether alone or with their loved ones.

To learn more about Two Botanika and the latest projects, visit the official Facebook page at facebook.com/BotanikaAlabangOfficial.

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Product Showcase

Citadines Roces Quezon City showcased

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In the heart of Quezon City stands Citadines Roces Quezon City, a testament to The Ascott Limited’s expanding footprint in the Philippines. As one of the properties from The Ascott Limited, it exemplifies the brand’s commitment to providing exceptional hospitality and top-tier accommodations.

With its modern design, diverse accommodations, extensive amenities, and a prime location, Citadines Roces Quezon City caters to both business and leisure travelers, offering a seamless blend of comfort and convenience. Whether for business conferences, social gatherings, or intimate celebrations, Citadines Roces Quezon City offers the perfect venue tailored to its guests’ needs.

Strategically located in a bustling metropolis

Nestled in Quezon City, Citadines Roces Quezon City prides itself for its ideal location for both travelers and their various demands and needs. As the largest city in Metro Manila, Quezon City is a dynamic hub of commerce, entertainment, and culture. Its position gives guests seamless access to government institutions, corporate offices, premier shopping destinations, and a vibrant dining scene. This makes it an attractive destination for travelers seeking convenience and a rich urban experience.

Unleash your event’s full potential with the property’s premier function rooms

To fully realize the property’s vision, one of the biggest highlights of Citadines Roces Quezon City is its state-of-the-art function rooms, designed to host various events with elegance and sophistication. These premier spaces are meticulously crafted to provide an ideal setting for any occasion. From corporate meetings and seminars to weddings and social events, the function rooms are equipped with the latest technology and amenities to ensure the success of every gathering. 

The function rooms are versatile, offering customizable layouts to suit the specific requirements of each event. Additionally, the dedicated event planning team at the property are available to assist with every detail, from menu selection to technical support. The attentive and professional staff are committed to providing exceptional service, ensuring that every event is executed flawlessly. With their expertise and attention to detail, you can be confident that your event at Citadines Roces Quezon City will be memorable and successful.

Each room features high-quality audio-visual equipment, including projectors, screens, and sound systems, to facilitate seamless presentations and multimedia experiences. The modern decor and flexible seating further enhance the ambiance, making it suitable for all events and social gatherings.

“Our function rooms are designed to cater to the unique needs of each event, offering customizable layouts and comprehensive support,” says Ms. Thea Peregrino, Assistant Residence Manager at Citadines Roces Quezon City. “Our dedicated event planning team and professional staff are committed to providing exceptional service, ensuring every event is executed flawlessly and leaves a lasting impression.”

In addition to the variety of inclusions to the function spaces, each individually curated event will be catered to by the residence’s flagship restaurant and bar, Alejo. Serving a robust selection of intercontinental cuisine with Filipino flavors at the helm, the restaurant can seamlessly customize an exceptional menu fit for any occasion. With its modern chic and wood-accented aesthetic, the outlet is also perfect for a more gastronomic focus setting, providing unlimited culinary experiences and food journeys for everyone to enjoy.  

No matter the event’s nature, find the perfect venue at Citadines Roces Quezon City. With its strategic location, comprehensive accommodation options, and premier function spaces, it stands as the ideal choice for creating unforgettable moments.

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Beauty & Fashion

PUMA drops new Deviate Nitro 3

With the third iteration of Deviate, PUMA is redefining speed in a way the running scene is yet to experience, empowering runners to unlock new personal bests.

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Deviate means to do things differently. To not accept normal standards. To challenge the status quo. Deviate inspires you to not just go beyond your boundaries, but to shatter them in emphatic style.

With the third iteration of Deviate, PUMA is redefining speed in a way the running scene is yet to experience, empowering runners to unlock new personal bests.

Embodying PUMA’s relentless pursuit of excellence in performance footwear, Deviate provides runners with the confidence to hit the road, making every second count.

This new offering sees Deviate served up in a new  distinct model; Deviate NITRO 3 – a premium everyday hero.

Deviate NITRO 3

The Deviate NITRO 3 challenges runners to have the most successful training experience ever. It’s the everyday source of speed that runners can trust week after week, mile after mile.

The shoe is engineered with even more of PUMA’s cutting-edge NITROFOAM technology to deliver supreme cushion and responsiveness, elevating the legacy of its award-winning predecessor.

The carbon fibre PWR Plate offers a smoother and more consistent source of speed, resulting in an explosive toe-off that propels runners beyond their normal limits, whilst PUMA’s unrivalled PUMAGRIP enables multi-surface traction in even the most testing conditions.

A lightweight engineered mesh upper features strategically placed PWR Tape to provide support in high stress areas, with a padded collar offering additional comfort and fit.

Sure to enhance the training experience for people around the globe, Deviate NITRO 3 continues to grow closer to its raceday counterpart.

Deviate NITRO 3 Specifications:

  • Price: PHP 8, 800
  • Weight: 265g (UK8)
  • Stack Height: 29mm – 39mm

Commenting on the hotly anticipated double dose of Deviate, Romain Girard, VP Innovation at PUMA said: “We’re living in a world where athletes and runners have high expectations. They want to set PBs and break records, time and time again. To do that, you need a shoe that gives you the competitive edge – that’s where Deviate comes in. The Deviate NITRO™ 3 is now available globally on PUMA.com, in PUMA stores and selected retailers.

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