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Dog’s body size and shape could indicate a greater bone tumor risk

The findings that bone tumors are more common in certain breeds and conformations indicates that a dog’s genetics play a role in bone tumor development. This link between the biology of conformation and the biology of bone tumors in dogs provides valuable opportunities for further study into what causes bone tumors to develop, and how they could be treated in the future.

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Osteosarcoma is a painful and aggressive bone tumor in dogs that is known to be more common in certain breeds than others. New research has now confirmed that larger breeds, such as Rottweiler, Great Dane and Rhodesian Ridgeback, have a greater risk of osteosarcoma than smaller breeds, as well as showing that breeds with shorter skulls and legs have lower osteosarcoma risk. The findings could inform future breed health reforms as well as studies into the way tumors develop from normal bone.

The study led by the University of Bristol Veterinary School in collaboration with Cardiff University and Royal Veterinary College (RVC) London, and using data from VetCompass™ and Veterinary Pathology Group (VPG) histology, looked at the epidemiology surrounding which dog breeds get osteosarcoma, and what this means for canine welfare. This study also shows the huge benefits from studying dogs as a model to study this cancer. The findings are published in Canine Medicine and Genetics today [10 March].

The study included 1,756 laboratory-confirmed osteosarcoma cases in dogs compared with 905,211 dogs under veterinary care in the VetCompass database during 2016.

The research team found twenty-seven breeds, mainly larger breeds, had an increased risk of osteosarcoma compared to crossbreeds. Thirty breeds, mainly smaller breeds, including Jack Russell, Border Terrier, Bichon Frise, French Bulldog, Cavalier King Charles Spaniel, had reduced risk of osteosarcoma compared to crossbreeds.

The study also compared various measures of body mass and leg length, and confirmed previous findings that heavier dogs with longer legs and longer skull shapes are at greatest risk of bone tumours. The results could inform breed health reforms, especially in predisposed breeds such as the Rottweiler, Great Dane and Rhodesian Ridgeback, Mastiff and German Pointer. Whereas previous studies have identified high-risk breeds for bone tumours, this paper is novel by being able to identify breeds at lowest risk because of the huge size of the study population. The breeds identified here could be researched and compared to recognise novel genetic differences which cause bone tumours.

The findings that bone tumors are more common in certain breeds and conformations indicates that a dog’s genetics play a role in bone tumor development. This link between the biology of conformation and the biology of bone tumors in dogs provides valuable opportunities for further study into what causes bone tumors to develop, and how they could be treated in the future.

Osteosarcoma can affect any dog breed. However, owners of high-risk breeds should be especially alert for signs of the disease. These include lameness and painful, bony swelling and dog owners should contact their vet if concerned.

Dr Grace Edmunds, Clinical Veterinary Research Fellow and lead author at Bristol Veterinary School, said: “As a vet, I am always focussed on improving animal welfare by looking outwards to find new treatments for their diseases. As osteosarcoma also affects adolescents, it is hugely exciting that by understanding the biology of bone tumors, and working with my collaborators in human cancer research, we may make a difference to both canine and human cancer patients.”

Dr Dan O’Neill, Senior Lecturer in Companion Animals Epidemiology at the RVC, added: “There are increasing concerns about the wisdom of breeding dogs with extreme body shapes such as flat-faced breeds like French Bulldogs or breeds with long backs such as Dachshunds.

“This study highlights the health risks from another extreme body shape – large body size. The breeds at highest risk of osteosarcoma were large-sized breeds such as Rottweiler, Great Dane and Mastiff. To reduce the risks of picking a dog that may develop bone cancer, owners may need to consider choosing puppies from smaller-sized parents of these giant breeds or opting for different smaller breeds instead.”

Professor Rachel Errington at Cardiff University explained: “As a human cancer researcher at the School of Medicine this study shows that we can propose similar questions in human and canine disease with the aim of determining new therapies and diagnostics for both and this provides an exciting opportunity of joining forces across a diverse group of expertise.”

The research team is currently developing a project that will sequence certain genes in at-risk and protected breeds for osteosarcoma, with the aim of identifying those genetic pathways that cause bone tumors to develop from normal bone. Identifying such pathways will allow new drugs, or older, repurposed drugs, to be used to see if the outcomes when treating bone tumors in dogs can be improved.

Drs Grace Edmunds and Helen Winter, members of the study team, will be engaging with owners of dogs with cancer and younger patients who have had cancer as part of a One Health approach, and they would welcome contact from patients or dog owners who would like to participate in this research.

Pet Care

Tips for smooth travel with pets

The American Veterinary Medical Association (AVMA) recommends planning ahead for calm, comfortable trips for you and your pets.

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The American Veterinary Medical Association (AVMA) recommends planning ahead for calm, comfortable trips for you and your pets.

According to AVMA President, Dr. Michael Q. Bailey, visit your veterinarian to make sure your pet is current on all vaccinations and you have all the paperwork and medications necessary for your journey.

“Summer travel is exciting, but it comes with real responsibilities for pet owners that are easy to overlook,” said Dr. Bailey. “Before you head out, talk to your veterinarian. Whether your pet is coming along or staying behind, a little preparation can make all the difference.”

Bailey’s advice begins with considering whether travel is right for your pet, as some dogs, cats, and other animals may be uncomfortable with travel due to illness, injury or temperament. Consider a pet sitter or boarding your pet if there’s a chance they may not be comfortable traveling. If you’ve decided to bring your pet along, here are the AVMA’s top pet travel tips:

The Basics

  • Ensure your pet has up-to-date ID tags and a microchip.
  • Introduce your pet to their carrier and travel harness before the trip. Placing a familiar toy or blanket in the carrier can help your pet feel more comfortable.
  • Check your airline’s or carrier’s pet travel policies before you depart.

What to Bring

  • Proof of vaccination, pet ID info, and a recent photograph.
  • Leash, water dish, waste bags, blankets, treats, car carrier, toys and a pet first aid kit.
  • Enough food to last the entire trip.
  • Your pet’s medications and your veterinarian’s phone number.

For Added Comfort and Safety

  • Research a list of veterinarians in your destination in case of emergency.
  • Offer your pet water frequently, and take time for exercise and bathroom breaks.
  • Never, ever leave your pet alone in a parked car.
  • If you plan to stay in a hotel, motel, park, or campground, ask if there are any breed or size restrictions; if any paperwork is required; and what features they may offer to meet your pet’s needs.

For more information, visit www.avma.org.

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Pet Care

Living with cats does not worsen asthma in children, suggests study

Children living with a cat had similar asthma severity, exacerbation, asthma control, and lung function to children living without cats in the short term.

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Asthma is the most common chronic disease and one of the main causes of hospitalization among children. The Global Asthma Network has estimated that its global prevalence is 9.1% for children and 11.0% for adolescents, but this percentage varies greatly between countries, regions, and environments. Worldwide, the highest prevalence of pediatric asthma (above 20%) occurs in the British Isles and in parts of Oceania and the Middle East. Known risk factors for developing asthma include exposure to air pollution and smoking, childhood viral infections, obesity, and pre-existing allergies like eczema or hay fever.

Patients anecdotally self-report that exposure to animal dander appears to trigger asthma attacks. However, clinical and epidemiological data on this is so far contradictory, coming mostly from small studies on subgroups that aren’t necessarily representative of the wider population. Now, researchers have demonstrated in Frontiers in Allergy that sharing a home with cats may not worsen the outcomes of children with asthma and allergies.

“Here we show in a… cohort of children in Sweden with asthma and allergies, that children living with a cat had similar asthma severity, exacerbation, asthma control, and lung function to children living without cats in the short term,” said corresponding author Dr Resthie R Putri, a postdoctoral fellow at Karolinska Institutet in Stockholm.

“We also did not see any differences in asthma outcomes related to the number of cats, the cat’s sex, or the cat’s age.”

Large pediatric sample

In 2023, Putri and colleagues began a study on a cohort of 30,277 children – between four and 17 years old at the time – born between 2006 and 2020 and diagnosed with asthma or an airway allergy. They followed these over 24 months until 2024 to track asthma outcomes, drawing records on diagnoses, emergency visits, prescribed medications, and asthma control test and spirometry tests from linked data in the Swedish National Patient Register, Prescribed Drug Register, and National Airway Register.

In Sweden, registration in the National Cat Register has been mandatory since 2023 for all pet cats born after 2008. For each child, the authors noted whether the parental household had at least one cat in 2023, as was true for 9.4% of the children.

Cats don’t worsen asthma in kids

The results showed that there was no significant association between exposure to pet cats and asthma outcomes. For example, moderate-to-severe asthma – based on prescribed asthma medications – occurred in 9.6% of the cat-exposed children and 10.1% of the non-exposed children. Asthma ‘exacerbation’ (also known as an attack or flare-up) occurred in 3.3% of the cat-exposed children and 3.5% of the non-exposed children.

Among a subset of 1,428 children for whom asthma control and lung spirometry data were available, 97 (6.8%) lived with cats. There were no significant differences between the two groups in two common measures of lung function.

“One possible explanation is that cat allergen exposure is very common, even outside the home. Children who do not have cats at home may still be exposed in shared environments such as schools or public transportation, which could explain why we didn’t see a difference,” said Putri.

“While these large-scale findings provide valuable insight, we lacked data on which allergens the children were sensitized to, and because the National Cat Register is relatively new, some children living with cats may have been misclassified as unexposed,” she cautioned.

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Pet Care

Tips to keep pets safe and happy no matter the season

The American Veterinary Medical Association (AVMA) is reminding everyone to keep pets safe no matter the season, and to think twice before gifting a pet as a surprise.

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Special occasions can be a magical time, but they can also present hidden pet hazards and difficult decisions for pet owners and gift-givers. The American Veterinary Medical Association (AVMA) is reminding everyone to keep pets safe no matter the season, and to think twice before gifting a pet as a surprise.

“Holiday celebrations often mean delicious foods, beautiful decorations, and friends and family, which can be wonderful for us but may pose unexpected risks to our pets,” says Dr. Michael Q. Bailey, president of the AVMA. “The best gift you can give your pet… is the gift of good health and safety, which means keeping seasonal hazards out of reach, providing a quiet space away from the hustle and bustle, and ensuring emergency plans are in place in case the unexpected happens.”

Common hazards for pets include chocolate, baked goods (especially those containing the sugar substitute xylitol), table scraps, and certain seasonal plants like lilies, holly, and mistletoe. Tinsel, candles, electrical cords, and trees can also lead to injuries or worse if pets decide to investigate too closely.

Thinking about gifting a pet? Think again.
While the idea of a new puppy or kitten under the tree may warm hearts, the AVMA cautions against surprising someone with a live animal. Pets are long-term commitments that require a significant amount of time, planning, financial resources, and emotional investment.

“Bringing a pet into someone’s life is a decision that should never be made impulsively, and never without the foreknowledge of the recipient,” says Dr. Bailey. “Pets can bring immense joy, but they also require daily care, training, veterinary visits, and love for many years. A better option might be wrapping up a collar, toy, or gift certificate, and involving the future pet owner in choosing their new companion when the time is right.”

Instead of gifting a live animal, the AVMA recommends more thoughtful alternatives, such as:

  • A leash or collar with a note promising a trip to a shelter or reputable breeder
  • Books on pet care or breed characteristics
  • A donation in the recipient’s name to a local animal shelter

Healthy gift ideas for pets
If your own pets are on your holiday list, the AVMA suggests practical and healthy gifts, such as:

  • A veterinary wellness exam
  • Toys that encourage exercise and mental stimulation
  • Nutritional treats made for pets
  • Updated parasite prevention
  • Pet insurance
  • A microchip (or updating existing chip info)

“Even something as simple as a microchip can be a lifesaving gift if your pet ever becomes lost,” adds Dr. Bailey. “It’s a gift that lasts a lifetime, and helps to ensure that you will be reunited if you and your pets become separated.”

For more holiday pet safety tips and resources, visit AVMA.org/holiday.

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