{"id":9347,"date":"2024-05-31T18:32:51","date_gmt":"2024-05-31T10:32:51","guid":{"rendered":"http:\/\/zestmag.com\/online\/?p=9347"},"modified":"2024-05-31T18:33:13","modified_gmt":"2024-05-31T10:33:13","slug":"intermittent-fasting-shows-promise-in-improving-gut-health-weight-management","status":"publish","type":"post","link":"https:\/\/zestmag.com\/online\/intermittent-fasting-shows-promise-in-improving-gut-health-weight-management\/","title":{"rendered":"Intermittent fasting shows promise in improving gut health, weight management"},"content":{"rendered":"\n

A new study by researchers from Arizona State University and their colleagues highlights a dietary strategy for significant health improvement and weight management.<\/strong><\/p>\n\n\n\n

Participants following an intermittent fasting and protein-pacing regimen, which involves evenly spaced protein intake throughout the day, saw better gut health, weight loss and metabolic responses. These benefits were notably greater than those seen with simple calorie restriction.<\/p>\n\n\n\n

The findings<\/a>, reported in the journal\u00a0Nature Communications<\/em>, could advance our understanding of the relationship between the gut microbiome and metabolism and improve strategies for managing obesity.<\/p>\n\n\n\n

The researchers compared the effects of two low-calorie dietary interventions: a heart-healthy continuous calorie-restricted diet (based on USDA dietary recommendations<\/a>), and a calorie-restricted regimen incorporating intermittent fasting and protein pacing.<\/p>\n\n\n\n

The trial was conducted with 41 individuals who were overweight or obese over a period of eight weeks. Individuals in the intermittent fasting and protein-pacing group showed a decrease in symptoms of gastrointestinal problems and an increase in diversity of the gut microbiota compared with those in the calorie-restriction group.<\/p>\n\n\n\n

The intermittent fasting protocol increased beneficial microbes in the gut that have been linked to a lean body type and improved overall health. Additionally, it increased the levels of certain proteins (cytokines) in the blood associated with weight loss, as well as amino acid byproducts that promote fat burning.<\/p>\n\n\n\n

Intermittent fasting is an eating pattern that cycles between periods of fasting and eating. The method has recently gained popularity for its potential health benefits, including weight loss, improved metabolic health and enhanced brain function.<\/p>\n\n\n\n

“Given the gut microbiota’s location and its constant interaction with the GI tract, we have been\u00a0gaining a deeper understanding of its pivotal role in dietary responses these\u00a0last several years,\u201d says\u00a0Alex Mohr, lead author of the new study. \u201cWhile limited in duration and\u00a0sample size, this comprehensive investigation \u2014 which included the analysis of the gut microbiome, cytokines, fecal short-chain fatty acids and blood metabolites \u2014 underscores the intricate interplay between diet, host metabolism and microbial communities.\u201d<\/p>\n\n\n\n

Mohr led the microbiome and molecular investigations, evaluating gut microbial composition, inflammatory molecules called cytokines, SCFAs (metabolites derived from dietary fiber, important for regulating energy balance) and the metabolome.<\/p>\n\n\n\n

Mohr is a researcher with the\u00a0Biodesign Center for Health Through Microbiomes\u00a0at ASU.\u00a0Rosa Krajmalnik-Brown, the center director, and researchers Devin Bowes,\u00a0Karen Sweazea\u00a0and\u00a0Corrie Whisner\u00a0are also contributors to the study.<\/p>\n\n\n\n

Corresponding author Paul Arciero of the Department of Health and Human Physiological Sciences at Skidmore College led the clinical trial, which tracked weight loss and body composition.<\/p>\n\n\n\n

The study also included contributions from ASU researchers\u00a0Paniz Jasbi\u00a0and\u00a0Judith Klein-Seetharaman, with the\u00a0School of Molecular Sciences, and\u00a0Dorothy Sears\u00a0and\u00a0Haiwei Gu, with the\u00a0College of Health Solutions. \u00a0<\/p>\n\n\n\n

Diet, microbiome and weight loss<\/strong><\/p>\n\n\n\n

The gut microbiome refers to the diverse community of microorganisms residing in the gastrointestinal tract, including bacteria, viruses, fungi and other microbes. Numbering in the many trillions of organisms, this complex ecosystem plays a crucial role in essential bodily functions and overall health.<\/p>\n\n\n\n

The gut microbiome helps break down food, produce vitamins and promote the absorption of nutrients. It plays a role in the development and function of the immune system by protecting the body against harmful pathogens. Finally, the gut microbiome keenly regulates metabolism,\u00a0 impacting body weight, fat storage and insulin sensitivity.<\/p><\/blockquote>\n\n\n\n

Caloric restriction, intermittent fasting (limiting food consumption to certain windows on some days) and protein pacing (controlled protein intake at specific meals) have been shown to affect body weight and composition, but the effect of these dietary modifications on the gut microbiome has been unclear until now.<\/p>\n\n\n\n

\u201cA healthy gut microbiome is essential for overall health, particularly in managing obesity and metabolic diseases,” says Sweazea, the ASU principal investigator of this Isagenix<\/a>-funded study. \u201cThe gut bacteria influence how we store fat, balance glucose levels and respond to hormones that make us feel hungry or full. Disruptions in the gut microbiota can lead to increased inflammation, insulin resistance and weight gain, underscoring the critical role of gut health in preventing and managing metabolic disorders.”<\/p>\n\n\n\n

Study and findings<\/strong><\/p>\n\n\n\n

The clinical trial involved 27 female and 14 male participants who were overweight or obese.  Participants were divided into two groups: one following the intermittent fasting and protein pacing regimen, and the other adhering to a heart-healthy, calorie-restricted diet. Both groups were monitored over eight weeks for changes in weight, body composition, gut microbiome composition and plasma metabolomic signatures.<\/p>\n\n\n\n

Participants following the intermittent fasting and protein pacing regimen experienced a significant reduction in gut symptoms and an increase in beneficial gut bacteria, particularly from the Christensenellaceae family. The study also found these microbes are associated with improved fat oxidation and metabolic health. In contrast, the calorie-restricted group showed an increase in metabolites linked to longevity-related pathways.<\/p>\n\n\n\n

Despite both groups having similar average weekly energy intake, the intermittent fasting and protein pacing group achieved greater weight loss and fat reduction with an average loss of 8.81% of their initial body weights during the study. In comparison, those on a calorie-restricted diet lost an average of 5.4% body weight.<\/p>\n\n\n\n

Participants who followed the intermittent fasting and protein-pacing diet experienced reductions in overall body fat, including belly fat and deep abdominal fat, and saw an increase in the percentage of lean body mass.<\/p>\n\n\n\n

The study underscores the potential of intermittent fasting and protein-pacing diets in improving gut health and weight management. While further research is necessary, these findings offer a promising avenue for creating effective dietary interventions for obesity and related metabolic disorders.<\/p><\/blockquote>\n\n\n\n

\u201cBy identifying shifts in specific microbes, functional pathways and associated metabolites, this line of work holds promise for personalized health strategies as we can better tailor nutritional regimens to enhance gut function and metabolic outcomes,” Mohr says.<\/p>\n\n\n\n

Additional institutions contributing to the study: Systems Precision Engineering and Advanced Research (SPEAR); Center of Translational Science, Florida International University; Isagenix International LLC; and the School of Health and Rehabilitation Sciences, Department of Sports Medicine and Nutrition, University of Pittsburgh.<\/p>\n","protected":false},"excerpt":{"rendered":"

Participants following an intermittent fasting and protein-pacing regimen, which involves evenly spaced protein intake throughout the day, saw better gut health, weight loss and metabolic responses.<\/p>\n","protected":false},"author":3,"featured_media":7393,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4],"tags":[801,2473,1827],"class_list":["post-9347","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-newsmakers","tag-diet","tag-fasting","tag-mediterranean-diet"],"_links":{"self":[{"href":"https:\/\/zestmag.com\/online\/wp-json\/wp\/v2\/posts\/9347","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zestmag.com\/online\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zestmag.com\/online\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zestmag.com\/online\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/zestmag.com\/online\/wp-json\/wp\/v2\/comments?post=9347"}],"version-history":[{"count":1,"href":"https:\/\/zestmag.com\/online\/wp-json\/wp\/v2\/posts\/9347\/revisions"}],"predecessor-version":[{"id":9348,"href":"https:\/\/zestmag.com\/online\/wp-json\/wp\/v2\/posts\/9347\/revisions\/9348"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/zestmag.com\/online\/wp-json\/wp\/v2\/media\/7393"}],"wp:attachment":[{"href":"https:\/\/zestmag.com\/online\/wp-json\/wp\/v2\/media?parent=9347"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zestmag.com\/online\/wp-json\/wp\/v2\/categories?post=9347"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zestmag.com\/online\/wp-json\/wp\/v2\/tags?post=9347"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}