{"id":1158,"date":"2015-08-12T12:11:55","date_gmt":"2015-08-12T12:11:55","guid":{"rendered":"http:\/\/zestmag.com\/online\/?p=1158"},"modified":"2015-08-12T12:13:56","modified_gmt":"2015-08-12T12:13:56","slug":"menopause-associated-with-more-fat-around-heart-raising-risk-for-heart-disease","status":"publish","type":"post","link":"https:\/\/zestmag.com\/online\/menopause-associated-with-more-fat-around-heart-raising-risk-for-heart-disease\/","title":{"rendered":"Menopause associated with more fat around heart, raising risk for heart disease"},"content":{"rendered":"

Late- and post-menopausal women have significantly greater volumes of fat around their hearts \u2013 a risk factor for heart disease \u2013 than their pre-menopausal counterparts, a\u00a0University of Pittsburgh Graduate School of Public Health<\/a> study has shown for the first time.<\/strong><\/p>\n

\"The<\/a><\/p>\n

The finding, scheduled for the September 1 issue of\u00a0The Journal of Clinical Endocrinology & Metabolism<\/a><\/em>, likely can be attributed to changing hormone levels and could guide potentially life-saving interventions. The work was funded by the\u00a0National Institutes of Health<\/a> (NIH) and American Heart Association<\/a> (AHA).<\/p>\n

\u201cCardiovascular disease is the leading cause of death in women, and it increases after age 50 \u2013 the average age when a woman is going through menopause,\u201d said lead author Samar R. El Khoudary, Ph.D., M.P.H., assistant professor in Pitt Public Health\u2019s\u00a0Department of Epidemiology<\/a>. \u201cBy showing that menopause appears to be associated with a shift in fat deposits that leads to more fat around the heart, we\u2019ve uncovered a new potential contributor to increased risk of cardiovascular disease in women.\u201d<\/p>\n

Weight gain in women during and after menopause has long been attributed to aging, rather than menopause itself. However, recent research identified changes in body fat composition and distribution due to menopause-related hormonal fluctuations.<\/p>\n

No previous study had evaluated whether those changes in fat distribution during menopause affect cardiovascular fat. Increased and excess fat around the heart and vasculature can be more detrimental than abdominal fat, causing local inflammation and leading to heart disease. Doubling certain types of cardiovascular fat can lead to a more than 50 percent increase in coronary events.<\/p>\n

El Khoudary and her team evaluated clinical data, including blood samples and heart CT scans, on 456 women from Pittsburgh and Chicago enrolled in the Study of Women\u2019s Health Across the Nation<\/a> (SWAN). The women averaged about 51 years of age and were not on hormone replacement therapy.<\/p>\n

As concentrations of the sex hormone estradiol \u2013 the most potent estrogen \u2013 declined during menopause, greater volumes of cardiovascular fat were found. The finding held even after the team took into account the effects of age, race, obesity, physical activity, smoking, alcohol consumption, medication use and chronic diseases.<\/p>\n

\u201cDeveloping prevention strategies to reduce cardiovascular fat in women at midlife may reduce their heart disease risk, especially knowing that the menopausal transition puts women at risk for excess fat around their hearts,\u201d said El Khoudary. \u201cPrevious studies suggest that reducing heart fat is feasible through weight loss or weight management, but these studies only looked at small numbers of people and there have been no clinical trials linking cardiovascular outcomes with heart fat changes due to weight management interventions. Clearly there is a need for larger scale studies to determine the best intervention strategies to help post-menopausal women reduce fat near the heart.\u201d<\/p>\n

El Khoudary and her research team are now working on evaluating whether cardiovascular fat volumes progress over time in midlife women, and, if so, whether this progression will be associated with greater evolution in atherosclerosis and more cardiovascular events in post-menopausal women.<\/p>\n

Additional authors on this study are senior author Karen A. Matthews, Ph.D., of Pitt; and co-authors Kelly J. Shields, Ph.D., of Allegheny Health Network; Imke Janssen, Ph.D., and Lynda H. Powell, Ph.D., both of Rush University Medical Center; Carrie Hanely and Emma Barinas-Mitchell, Ph.D., both of Pitt; Matthew Budoff, M.D., of the Los Angeles Biomedical Research Institute; and Susan A. Everson-Rose, Ph.D., of the University of Minnesota Medical School.<\/p>\n","protected":false},"excerpt":{"rendered":"

Late- and post-menopausal women have significantly greater volumes of fat around their hearts \u2013 a risk factor for heart disease \u2013 than their pre-menopausal counterparts, a University of Pittsburgh Graduate School of Public Health study has shown for the first time.<\/p>\n","protected":false},"author":3,"featured_media":1159,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[9,36,35],"tags":[694,693],"class_list":["post-1158","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-fitness","category-health-wellness-2","category-wellness-2","tag-heart-disease","tag-menopause"],"_links":{"self":[{"href":"https:\/\/zestmag.com\/online\/wp-json\/wp\/v2\/posts\/1158","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zestmag.com\/online\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zestmag.com\/online\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zestmag.com\/online\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/zestmag.com\/online\/wp-json\/wp\/v2\/comments?post=1158"}],"version-history":[{"count":2,"href":"https:\/\/zestmag.com\/online\/wp-json\/wp\/v2\/posts\/1158\/revisions"}],"predecessor-version":[{"id":1161,"href":"https:\/\/zestmag.com\/online\/wp-json\/wp\/v2\/posts\/1158\/revisions\/1161"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/zestmag.com\/online\/wp-json\/wp\/v2\/media\/1159"}],"wp:attachment":[{"href":"https:\/\/zestmag.com\/online\/wp-json\/wp\/v2\/media?parent=1158"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zestmag.com\/online\/wp-json\/wp\/v2\/categories?post=1158"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zestmag.com\/online\/wp-json\/wp\/v2\/tags?post=1158"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}