{"id":11174,"date":"2026-05-18T11:20:08","date_gmt":"2026-05-18T03:20:08","guid":{"rendered":"https:\/\/zestmag.com\/online\/?p=11174"},"modified":"2026-05-18T11:20:10","modified_gmt":"2026-05-18T03:20:10","slug":"grape-consumption-linked-to-changes-in-gene-expression-and-improved-skin-health","status":"publish","type":"post","link":"https:\/\/zestmag.com\/online\/grape-consumption-linked-to-changes-in-gene-expression-and-improved-skin-health\/","title":{"rendered":"Grape consumption linked to changes in gene expression and improved skin health"},"content":{"rendered":"\n

Clinical trials have\u00a0shown\u00a0that consumption of grapes can increase the resilience of skin to UV\u00a0irradiation\u00a0in about 30-50% of the\u00a0subject\u00a0population.\u00a0<\/strong><\/p>\n\n\n\n

New\u00a0studies<\/a>\u00a0published in the\u00a0current\u00a0issue of the journal\u00a0ACS Nutrition Science<\/em>\u00a0suggest\u00a0the effect of consuming grapes on human skin health is much broader \u2013\u00a0most likely affecting\u00a0everyone.\u00a0<\/p>\n\n\n\n

The investigation was performed with human volunteers who consumed the equivalent of three servings of whole grapes each day for two weeks. Gene expression in skin was determined before and after grape consumption, with and without exposure of skin to low doses of UV irradiation. <\/p>\n\n\n\n

The results demonstrated inter- and intraindividual differences of gene expression in the skin. In other words, from the outset, gene expression in the skin of each individual was different. The expression changed when the subjects consumed grapes or when exposed to UV irradiation, but still each individual was different from one another. Further unique changes were observed when UV irradiation was combined with grape consumption. <\/p>\n\n\n\n

\n

Consequently, while gene expression is different when comparing one person to another person, the gene expression of every person changed after consuming grapes. <\/p>\n<\/blockquote>\n\n\n\n

When searching for a functional commonality resulting from these changes in gene expression after consuming grapes, the investigators were able to construe the myriads of data as being indicative of enhanced skin keratinization and cornification, which are known to create a\u202f barrier against environmental damage. This idea was reinforced by exposing skin to a low dose of UV irradiation and measuring the generation of malondialdehyde, a marker of oxidative stress, which was reduced when the subjects consumed grapes. <\/p>\n\n\n\n

\u00a0\u201cWe are now certain that grapes\u00a0act\u00a0as a superfood\u00a0and\u00a0mediate a nutrigenomic response in humans,\u201d\u00a0said John Pezzuto, Ph.D., Professor and Dean of the College of Pharmacy and Health Sciences at Western New England University.\u00a0<\/p>\n\n\n\n

\u201cWe\u00a0observed\u00a0this with the largest organ of the body, the skin.\u00a0The changes in gene expression\u00a0indicated\u00a0improvements in skin health. But\u00a0beyond skin,\u00a0it is\u00a0nearly certain\u00a0that grape consumption affects gene expression in other somatic tissues of the body, such as\u00a0liver, muscle, kidney and even brain.\u00a0This helps\u00a0us to understand how consumption of a\u00a0whole food, in this case grapes,\u00a0affects our overall health.\u00a0It\u2019s\u00a0very\u00a0exciting\u00a0to be\u00a0working\u00a0in\u00a0the\u00a0post-genomics era where we can finally start\u00a0to employ functional genomics and\u00a0actually visualize\u00a0complex\u00a0matrices indicative of nutrigenomic responses.\u201d\u00a0<\/p>\n","protected":false},"excerpt":{"rendered":"

Clinical trials have shown that consumption of grapes can increase the resilience of skin to UV irradiation in about 30-50% of the subject population.\u00a0<\/p>\n","protected":false},"author":3,"featured_media":11175,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4,11],"tags":[1101,1155,19,650,20],"class_list":["post-11174","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-newsmakers","category-nutrition","tag-fruits","tag-grapes","tag-health","tag-nutrition","tag-wellness"],"_links":{"self":[{"href":"https:\/\/zestmag.com\/online\/wp-json\/wp\/v2\/posts\/11174","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zestmag.com\/online\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zestmag.com\/online\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zestmag.com\/online\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/zestmag.com\/online\/wp-json\/wp\/v2\/comments?post=11174"}],"version-history":[{"count":1,"href":"https:\/\/zestmag.com\/online\/wp-json\/wp\/v2\/posts\/11174\/revisions"}],"predecessor-version":[{"id":11176,"href":"https:\/\/zestmag.com\/online\/wp-json\/wp\/v2\/posts\/11174\/revisions\/11176"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/zestmag.com\/online\/wp-json\/wp\/v2\/media\/11175"}],"wp:attachment":[{"href":"https:\/\/zestmag.com\/online\/wp-json\/wp\/v2\/media?parent=11174"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zestmag.com\/online\/wp-json\/wp\/v2\/categories?post=11174"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zestmag.com\/online\/wp-json\/wp\/v2\/tags?post=11174"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}