NewsMakers
What causes cervical cancer and how you can prevent it
Every year, more than 500,000 women are diagnosed with cervical cancer. In the Philippines, it is the second most common cancer among Filipino women aged 15 to 44 years old, with seven dying of the dreaded disease every single day.
At a press event organized by GSK Philippines, Esther Ganzon, Head of the Gynecologic Oncology Dept., Paranaque Doctors Hospital, says that cervical cancer occurs when abnormal cells develop and spread in the cervix, the entrance between the vagina and the uterus.
Ganzon notes that the incidence of cervical cancer starts rising steeply at age 30. It is highest in women ages 40 to 55 years old. “My youngest patient was a 11-year old girl who was sold as a sex worker since she was 5 years old by her mother,” revealed Ganzon.
So what causes cervical cancer?
Ganzon says that persistent infection with the human papillomavirus (HPV), a very common virus, is the necessary cause of cervical cancer. It has been shown that 99.7 percent of cervical cancer patients are positive for HPV infection. It is also estimated that up to 80 percent of women will be infected with HPV at some point in their lives.
There are more than 100 types of HPV, of which at least 13 are cancer-causing. Worldwide, HPV 16 and 18 contribute to 70% of all cancer cases, according to Ganzon.
The risk of developing cervical cancer is 250 to 400 times higher following persistent infection with oncogenic types compared to uninfected women.
The risk factors for HPV persistence and development of cervical cancer include tobacco smoking, early first sexual intercourse, multiple sexual partners, high parity, long-term use of oral contraceptive pills, and co-infection with HPV.
Ganzon says that while HPV is primarily transmitted via sexual intercourse, skin-to-skin genital contact is also a recognized mode of transmission.
What are the symptoms?
Ganzon warns that in its early stage (stages 1 and 2), cervical cancer may have no signs or symptoms. Symptoms only appear after the cancer has reached an advanced stage and may include:
– Irregular, intermenstrual (between periods) or abnormal vaginal bleeding after sexual intercourse
– back, leg or pelvic pain
– fatigue, weight loss, loss of appetite
– vaginal discomfort or odourous discharge
– a single swollen leg
More symptoms may arise at advanced stages.
How do you prevent it?
Sexual behavior can help prevent the development of cervical cancer, such as being conscientious about one’s sexual activities.
Beyond changing sexual behaviour, the disease can be prevented as early as 9 years of age through HPV vaccination, a primary prevention tool, says Ganzon. The World Health Organization recommends that routine HPV vaccination should be included in national immunization programs.
Secondary prevention includes screening which includes pap smear and HPV DNA test. Ganzon says that in low-resource settings, visual inspection with acetic acid is used to identify cervical lesions, which can be immediately treated by cyrotherapy.
Ganzon stressed that HPV vaccines are designed for prophylactic use only and does not eliminate screening later in life. She also emphasized that HPV vaccines do not clear existing HPV infection or treat HPV-related diseases.
HPV vaccines are “generally safe and effective,” claims Ganzon, adding that the most common reaction observed after vaccine administration was injection site pain.
Driving awareness
To ramp up its cervical cancer awareness efforts, GSK Philippines has launched the Power Over Cervical Cancer campaign which urges Filipinas to realize that they can do something to prevent the disease from happening to them.
To spread the awareness, GSK Philippines launched its partnership with cosmetics manufacturer VMV Hypoallergenics at a press event entitled “Put On Your Power Pout!”
The partnership introduces a twist on spreading awareness: encouraging women to join the movement by wearing purple lipstick to show their support for the advocacy on cervical cancer prevention.
“Cancer is quite a distant concept for women who are well. What might be more important to them is keeping up with the latest trends, especially in fashion and beauty. The lipstick is a woman’s own—when she wears it, she makes a statement about herself. Through this partnership with VMV, we hope to drive women to make a statement against cervical cancer,” says Mark Castillo, GSK product manager.
This article neither serves as a public health advisory nor endorses a product. Always consult your doctor before taking any treatment for any medical condition.
NewsMakers
Unlocking the science of sleep: How rest enhances language learning
Getting eight hours of sleep every night helps the brain to store and learn a new language.
Sleep is critical for all sorts of reasons, but a team of international scientists has discovered a new incentive for getting eight hours of sleep every night: it helps the brain to store and learn a new language.
A study led by the University of South Australia (UniSA) and published in the Journal of Neuroscience has revealed that the coordination of two electrical events in the sleeping brain significantly improves our ability to remember new words and complex grammatical rules.
In an experiment with 35 native English-speaking adults, researchers tracked the brain activity of participants learning a miniature language called Mini Pinyin that is based on Mandarin but with similar grammatical rules to English.
Half of the participants learned Mini Pinyin in the morning and then returned in the evening to have their memory tested. The other half learned Mini Pinyin in the evening and then slept in the laboratory overnight while their brain activity was recorded. Researchers tested their progress in the morning.
Those who slept performed significantly better compared to those who remained awake.
Lead researcher Dr Zachariah Cross, who did his PhD at UniSA but is now based at Northwestern University in Chicago, says sleep-based improvements were linked to the coupling of slow oscillations and sleep spindles – brainwave patterns that synchronise during NREM sleep.
“This coupling likely reflects the transfer of learned information from the hippocampus to the cortex, enhancing long-term memory storage,” Dr Cross says.
“Post-sleep neural activity showed unique patterns of theta oscillations associated with cognitive control and memory consolidation, suggesting a strong link between sleep-induced brainwave co-ordination and learning outcomes.”
UniSA researcher Dr Scott Coussens says the study underscores the importance of sleep in learning complex linguistic rules.
“By demonstrating how specific neural processes during sleep support memory consolidation, we provide a new perspective on how sleep disruption impacts language learning,” Dr Coussens says. “Sleep is not just restful; it’s an active, transformative state for the brain.”
The findings could also potentially inform treatments for individuals with language-related impairments, including autism spectrum disorder (ASD) and aphasia, who experience greater sleep disturbances than other adults.
Research on both animals and humans shows that slow oscillations improve neural plasticity – the brain’s ability to change and adapt in response to experiences and injury.
“From this perspective, slow oscillations could be increased via methods such as transcranial magnetic stimulation to accelerate aphasia-based speech and language therapy,” Dr Cross says.
In future, the researchers plan to explore how sleep and wake dynamics influence the learning of other complex cognitive tasks.
“Understanding how the brain works during sleep has implications beyond language learning. It could revolutionize how we approach education, rehabilitation, and cognitive training.”
NewsMakers
Home and neighborhood environments impact sedentary behavior in teens globally
Adolescents worldwide are spending an average of 8 to 10 hours per day engaging in sedentary activities such as watching television, using electronic devices, playing video games and riding in motorized vehicles.
The World Health Organization recommends no more than two to three hours per day of sedentary time for youth. However, adolescents worldwide are spending an average of 8 to 10 hours per day engaging in sedentary activities such as watching television, using electronic devices, playing video games and riding in motorized vehicles, according to a multinational study published in the Nov. 29, 2024 issue of the International Journal of Behavioral Nutrition and Physical Activity.
The most notable finding of the study, led by principal investigator James F. Sallis, Ph.D., distinguished professor at the Herbert Wertheim School of Public Health and Human Longevity Science at University of California San Diego, and colleagues from 14 countries, found that simply having a personal social media account was linked with higher total sedentary time in both males and females. Social media was also related to more self-reported screen time.
“Although there is great concern about negative effects of social media on youth mental health, this study documents a pathway for social media to harm physical health as well,” said Sallis, who is also a professorial fellow at the Australian Catholic University.
“These findings are concerning, as excessive sedentary behavior has been linked to a range of health problems, including obesity, diabetes and mental health issues.”
Researchers analyzed accelerometer data from 3,982 adolescents aged 11 to 19 and survey measures of sedentary behavior from 6,302 participants in the International Physical Activity and the Environment Network (IPEN) Adolescent Study, which covered 15 geographically and culturally diverse countries across six continents.
The number of electronic devices within a home, how many adolescents had their own social media accounts and neighborhood walkability were significantly different across countries.
For example, adolescents from India had an average of 1.2 electronic devices in the bedroom and 0.5 personal electronic devices, while the average number of such devices in Denmark was 4.2 and 2.3, respectively. In India and Bangladesh, fewer than 30% of adolescents reported having their own social media account, compared to higher socio-economic status countries where it was over 90%.
Parents reporting on walkability identified Australia as having high access to parks, while Nigerian parents reported no access, and parents in Bangladesh and India reported poor access. Traffic was a concern among parents in Brazil, Malaysia, Bangladesh, India, and Israel, and concerns about crime were high in the first three countries.
Adolescents who reported less recreational screen time lived in walkable neighborhoods and had better perceptions of safety from traffic and crime than others. Girls who lived in neighborhoods designed to support physical activity were less likely to be sedentary.
Despite differences in culture, built environments and extent of sedentary time, patterns of association were generally similar across countries, said the study’s lead author Ranjit Mohan Anjana, M.D., Ph.D., of Dr. Mohan’s Diabetes Specialties Centre and Madras Diabetes Research Foundation in India.
“Together, parents, policymakers and technology companies can work together to reduce access to screens, limit social media engagement and promote more physical activity, thus helping adolescents develop healthier habits and reduce their risk of chronic diseases,” said Anjana.
The study’s findings have significant implications for public health policy and highlight the need for further research into the causes and consequences of sedentary behavior among teenagers.
Countries involved in study: Australia, Bangladesh, Belgium, Brazil, China, Czechia, Denmark, India, Israel, Malaysia, Nigeria, Portugal, Spain and United States.
NewsMakers
People using vapes and cigarettes are less likely to quit and often switch to just smoking
Over a period of four to eight months, 30% of dual users switched to cigarettes only. Between eight and 16 months, 47% of dual users switched to cigarettes only. Between 16 and 24 months, the proportion was 58% and after 24 to 48 months, the proportion was 55%.
People who use both vapes and cigarettes are less likely to quit compared to people who only smoke or only vape, according to a study published in ERJ Open Research. Instead, the research suggests that over time, most of these ‘dual users’ tend to revert to only smoking cigarettes.
The researchers say their findings suggest that taking up vaping while continuing to smoke will probably not help people to stop smoking.
The study, by researchers from Germany, the USA and Denmark, was authored by Josef Hamoud from the University Medical Center Göttingen, Germany. It is a systematic review and meta-analysis, meaning researchers reviewed all existing research on people using both vapes and cigarettes and combined the data into one study.
Hamoud said: “Vaping has become widespread among adolescents and adults worldwide. Given the extensive marketing of vapes as healthier alternatives to conventional smoking, they have gained popularity among people trying to quit smoking. Some people are using them in addition to their conventional cigarettes, classifying them as dual users.
“There is still a lot we don’t know about the long-term health effects of vaping. However, credible studies have already delivered concerning results indicating that dual use might be even more harmful than conventional smoking.”
The review brings together 16 individual studies looking at whether groups of dual users went on to quit smoking, switch to vaping only, switch to smoking only or continue dual use over time. The analyses incorporate data on up to 9,337 people including 2,432 dual users.
When researchers compared dual users with people who only smoked cigarettes or only vaped, they found that dual users were less likely to quit completely. Over time, the analysis showed that the majority of dual users reverted to smoking conventional cigarettes.
The proportion of dual users who quit completely was 3% over a period of four to eight months, 5% by eight to 16 months, 13% by 16 to 24 months and 24% by 24 to 48 months. This compares to 6%, 7%, 17% and 25% respectively over the same time periods in people who only smoke and 8%, 19%, 26% and 35% respectively in people who only vape.
Over a period of four to eight months, 30% of dual users switched to cigarettes only. Between eight and 16 months, 47% of dual users switched to cigarettes only. Between 16 and 24 months, the proportion was 58% and after 24 to 48 months, the proportion was 55%.
Most dual users continued to use cigarettes across the time periods. Combining those who continued dual use with those who transitioned to smoking only, the total proportion using cigarettes ranged from 90% to 63%.
The researchers also point out that over the medium term (eight to 16 months), 38% of dual users were still using both vapes and cigarettes. “This cannot be considered a simple ‘transitional state’, but rather a risk for prolonged double exposure,” Hamoud said.
He continued: “Given these findings, we believe that dual use might prove to be a major hinderance in achieving smoking abstinence and this practice should not be recommended for treating nicotine addiction. In addition, while long term health effects of vapes need to be studied further, the double exposure to large amounts of nicotine and toxicants from both conventional cigarettes and vapes are a great concern for public health.”
The researchers say that because they were combining several studies, each with a slightly different approach, it was not possible to categorise different types of dual use, such as people who mostly smoke but occasionally vape.
Hamoud added: “While it may have been argued that heavy smokers might benefit from dual use by reducing their daily cigarette consumption, the high nicotine content of vapes adds to the risk of continued nicotine addiction. Future studies must further stratify dual-use groups to investigate the health implications over time.”
Dr Filippos Filippidis is Chair of the European Respiratory Society Tobacco Control Committee, a reader in public health at Imperial College London, UK, and was not involved in the research. He said: “We know that vaping is commonplace and that many people use e-cigarettes as well as cigarettes, often in the hopes of cutting down on smoking or quitting the habit. This large study examined all existing evidence on dual users, and it showed that, for most people, this is not a stepping stone to quitting”.
“Nicotine in vapes is highly addictive, so we need to do all we can to discourage non-smokers from starting to vape. E-cigarettes may have a role in smoking cessation for some people, but we need to make sure appropriate support is freely available to help people to quit, as it’s clear that many end up being dual users, which can actually undermine smoking cessation attempts.”
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