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Intermittent fasting shows promise in improving gut health, weight management

Participants following an intermittent fasting and protein-pacing regimen, which involves evenly spaced protein intake throughout the day, saw better gut health, weight loss and metabolic responses.

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A new study by researchers from Arizona State University and their colleagues highlights a dietary strategy for significant health improvement and weight management.

Participants following an intermittent fasting and protein-pacing regimen, which involves evenly spaced protein intake throughout the day, saw better gut health, weight loss and metabolic responses. These benefits were notably greater than those seen with simple calorie restriction.

The findings, reported in the journal Nature Communications, could advance our understanding of the relationship between the gut microbiome and metabolism and improve strategies for managing obesity.

The researchers compared the effects of two low-calorie dietary interventions: a heart-healthy continuous calorie-restricted diet (based on USDA dietary recommendations), and a calorie-restricted regimen incorporating intermittent fasting and protein pacing.

The trial was conducted with 41 individuals who were overweight or obese over a period of eight weeks. Individuals in the intermittent fasting and protein-pacing group showed a decrease in symptoms of gastrointestinal problems and an increase in diversity of the gut microbiota compared with those in the calorie-restriction group.

The intermittent fasting protocol increased beneficial microbes in the gut that have been linked to a lean body type and improved overall health. Additionally, it increased the levels of certain proteins (cytokines) in the blood associated with weight loss, as well as amino acid byproducts that promote fat burning.

Intermittent fasting is an eating pattern that cycles between periods of fasting and eating. The method has recently gained popularity for its potential health benefits, including weight loss, improved metabolic health and enhanced brain function.

“Given the gut microbiota’s location and its constant interaction with the GI tract, we have been gaining a deeper understanding of its pivotal role in dietary responses these last several years,” says Alex Mohr, lead author of the new study. “While limited in duration and sample size, this comprehensive investigation — which included the analysis of the gut microbiome, cytokines, fecal short-chain fatty acids and blood metabolites — underscores the intricate interplay between diet, host metabolism and microbial communities.”

Mohr led the microbiome and molecular investigations, evaluating gut microbial composition, inflammatory molecules called cytokines, SCFAs (metabolites derived from dietary fiber, important for regulating energy balance) and the metabolome.

Mohr is a researcher with the Biodesign Center for Health Through Microbiomes at ASU. Rosa Krajmalnik-Brown, the center director, and researchers Devin Bowes, Karen Sweazea and Corrie Whisner are also contributors to the study.

Corresponding author Paul Arciero of the Department of Health and Human Physiological Sciences at Skidmore College led the clinical trial, which tracked weight loss and body composition.

The study also included contributions from ASU researchers Paniz Jasbi and Judith Klein-Seetharaman, with the School of Molecular Sciences, and Dorothy Sears and Haiwei Gu, with the College of Health Solutions.  

Diet, microbiome and weight loss

The gut microbiome refers to the diverse community of microorganisms residing in the gastrointestinal tract, including bacteria, viruses, fungi and other microbes. Numbering in the many trillions of organisms, this complex ecosystem plays a crucial role in essential bodily functions and overall health.

The gut microbiome helps break down food, produce vitamins and promote the absorption of nutrients. It plays a role in the development and function of the immune system by protecting the body against harmful pathogens. Finally, the gut microbiome keenly regulates metabolism,  impacting body weight, fat storage and insulin sensitivity.

Caloric restriction, intermittent fasting (limiting food consumption to certain windows on some days) and protein pacing (controlled protein intake at specific meals) have been shown to affect body weight and composition, but the effect of these dietary modifications on the gut microbiome has been unclear until now.

“A healthy gut microbiome is essential for overall health, particularly in managing obesity and metabolic diseases,” says Sweazea, the ASU principal investigator of this Isagenix-funded study. “The gut bacteria influence how we store fat, balance glucose levels and respond to hormones that make us feel hungry or full. Disruptions in the gut microbiota can lead to increased inflammation, insulin resistance and weight gain, underscoring the critical role of gut health in preventing and managing metabolic disorders.”

Study and findings

The clinical trial involved 27 female and 14 male participants who were overweight or obese.  Participants were divided into two groups: one following the intermittent fasting and protein pacing regimen, and the other adhering to a heart-healthy, calorie-restricted diet. Both groups were monitored over eight weeks for changes in weight, body composition, gut microbiome composition and plasma metabolomic signatures.

Participants following the intermittent fasting and protein pacing regimen experienced a significant reduction in gut symptoms and an increase in beneficial gut bacteria, particularly from the Christensenellaceae family. The study also found these microbes are associated with improved fat oxidation and metabolic health. In contrast, the calorie-restricted group showed an increase in metabolites linked to longevity-related pathways.

Despite both groups having similar average weekly energy intake, the intermittent fasting and protein pacing group achieved greater weight loss and fat reduction with an average loss of 8.81% of their initial body weights during the study. In comparison, those on a calorie-restricted diet lost an average of 5.4% body weight.

Participants who followed the intermittent fasting and protein-pacing diet experienced reductions in overall body fat, including belly fat and deep abdominal fat, and saw an increase in the percentage of lean body mass.

The study underscores the potential of intermittent fasting and protein-pacing diets in improving gut health and weight management. While further research is necessary, these findings offer a promising avenue for creating effective dietary interventions for obesity and related metabolic disorders.

“By identifying shifts in specific microbes, functional pathways and associated metabolites, this line of work holds promise for personalized health strategies as we can better tailor nutritional regimens to enhance gut function and metabolic outcomes,” Mohr says.

Additional institutions contributing to the study: Systems Precision Engineering and Advanced Research (SPEAR); Center of Translational Science, Florida International University; Isagenix International LLC; and the School of Health and Rehabilitation Sciences, Department of Sports Medicine and Nutrition, University of Pittsburgh.

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Watsons hosts PowHER Forum

This forum encouraged women to embrace their authentic selves while celebrating their strength, grit, and achievements.

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Watsons hosted its first-ever “Move with PowHER” Forum, an inspiring event dedicated to women’s wellness and empowerment. This forum encouraged women to embrace their authentic selves while celebrating their strength, grit, and achievements. It brought together women from diverse backgrounds—professionals, entrepreneurs, artists, community leaders, and more—to connect, share experiences, and uplift one another. Through engaging discussions on physical, emotional, and mental wellness, career growth, leadership, and advocacy, Watsons aimed to empower women to thrive in every aspect of their lives.

A Platform for Authentic Conversation and Empowerment

The event opened with a keynote speech by Lynn Pinugu, co-founder of She Talks Asia, an advocacy platform dedicated to sparking meaningful conversations about women’s strength, mental health, and gender equality. Drawing from her personal journey as a mother, wife, and advocate, Lynn shared how embracing authenticity has shaped her life and inspired her to drive change. She highlighted how She Talks Asia helps women redefine empowerment by breaking societal barriers and embracing their unique identities.

Lynn’s message resonated deeply with Watsons’ brand promise of “Look Good, Do Good, Feel Great,” which champions the uniqueness of every woman and celebrates both inner and outer beauty. She highlighted how She Talks Asia aligns with this vision by encouraging women to embrace their individuality, support one another, and actively contribute to their communities. Through initiatives such as scholarship programs, employee volunteerism, and sustainability efforts, Watsons inspires women to make a positive impact on society. Watsons aims to empower women to “Move with PowHER,” using their voices and talents to drive meaningful change, uplift one another, and confidently pursue their passions and achievements.

The forum featured insightful panel discussions that highlighted key areas where women are making a difference:

Physical & Mental Wellness:

Hazel Calawod, a sports occupational therapist, mental health professional, and coach of two-time gold Olympian Carlos Yulo, emphasized the importance of building physical and mental resilience. Drawing from her experience coaching elite athletes, she highlighted how mental toughness and physical strength are essential not only for peak performance in sports but also for navigating everyday challenges.

Women in Sports:

Nicole Dela Cruz, CEO of Women’s Run PH and an advocate for women in sports, discussed the significance of representation and resilience. She shared her journey of overcoming challenges in a male-dominated field, underscoring the vital role of mentorship and collaboration in empowering female athletes to pursue their passions.

Balancing Family & Work Life:

Sharon Decapia, SAVP of Watsons’ Marketing, PR & Sustainability, offered insights on balancing her roles as a corporate executive and mother. She emphasized that true empowerment involves embracing both family and career with purpose and confidence. Sharon provided practical advice on achieving personal and professional goals while prioritizing self-care and wellness, encouraging women to nurture themselves as they pursue their ambitions.

Women in Advocacy:

Lynn Pinugu returned to discuss the role of advocacy in driving social change. She emphasized how authentic conversations on mental health, gender equality, and self-empowerment break societal barriers, inspiring women to embrace their unique strengths and lead with purpose.

A key theme of the “Move with PowHER” forum was the importance of building supportive communities where women uplift one another. By nurturing these connections, Watsons continues to serve as a trusted partner, providing resources, products, and platforms that help women excel in all aspects of life.

The event redefined traditional notions of leadership, presenting it as a form of advocacy—whether for oneself, for other women, or for broader social issues. Attendees were inspired by stories of women leaders who are effecting meaningful change and discovered how they can also lead with purpose and passion. Through the “Move with PowHER” initiative, Watsons encouraged women to see leadership as a powerful opportunity to make a difference in their communities and beyond.

The forum also provided a vibrant atmosphere with interactive activities. Guests participated in a floral workshop where they created their own arrangements, reflecting the themes of growth and self-expression. Brand segments featured PH Care, Gynepro, Jeunesse, and partners like Modess, Charmee, Cleane, and Sisters, celebrating products that support women’s health and wellness.

“Move with PowHER” embodied Watsons’ brand promise, championing every woman’s right to look good, do good, and feel great. By celebrating individuality, Watsons inspires women to embrace their unique beauty and confidence. Through initiatives like scholarship programs, volunteerism, and sustainability efforts, Watsons encourages women to give back to their communities. By nurturing their success and well-being, Watsons fosters vibrant, empowered communities where women can thrive.

Visit your nearest Watsons store or shop through the Watsons App, available for download on the App Store and Google Play, to discover your favorite health, wellness, and beauty products.

As part of Watsons’ commitment to supporting women, Watsons offers a wide range of products and services designed to enhance their health, wellness, and beauty journeys. From skincare and cosmetics to vitamins and personal care essentials, Watsons provides everything women need to look good, do good, and feel great. For added convenience, customers can shop their favorite products through the Watsons App, available for download on the App Store and Google Play, or visit their nearest Watsons store.

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Not in the mood for sex after menopause?

Many women report a decline in sexual function, including desire, when transitioning through menopause. Such problems can contribute to poor self-image and negatively affect physical and emotional well-being.

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Many women report a decline in sexual function, including desire, when transitioning through menopause. Such problems can contribute to poor self-image and negatively affect physical and emotional well-being. A new study suggests that cognitive behavioral therapy may be a safe and effective treatment for mitigating sexual concerns during this period.  

Partially due to declining estrogen levels, 68% to 87% of peri- and postmenopausal women express sexual concerns. Despite such high prevalence and negative impacts, treatment options–particularly nonpharmacological ones–are quite limited. In response, researchers initiated a small study to evaluate the efficacy of a four-session individual cognitive behavioral therapy protocol for improving sexual functioning (eg, desire, arousal, pain, satisfaction). Secondary objectives included assessing body image, relationship satisfaction, menopause symptoms (such as hot flashes), depression, and anxiety during peri- and postmenopause.

The researchers found that participants in this study experienced a significant improvement in multiple areas of sexual functioning, body image and couple satisfaction, as well as a significant decrease in menopause symptoms, depression, and anxiety, and self-reported overall health. In addition, 100% of participants indicated they were very satisfied with the treatment and that it helped them cope with their symptoms more effectively.

“To our knowledge, this is the first study that has examined the efficacy of a cognitive behavioral therapy protocol specifically aimed to improve sexual concerns experienced during peri- and postmenopause,” says Dr. Sheryl Green, lead study author from McMaster University in Ontario, Canada. “Results suggest that this type of therapy leads to significant improvements across several important sexual concern domains, and we hope this study will provide the basis for larger randomized clinical trials in the future.”

“This study is important to women experiencing sexual health related issues and provides their healthcare professionals with another nonpharmacologic treatment option to discuss with their patients,” says Dr. Stephanie Faubion, medical director for The Menopause Society.

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LIFEST: InsuRUNce 2024 slated on Oct. 12

Held in its second year, LUAP Insurance Festival or LIFEST is being held to commemorate the Life Insurance Consciousness Week, per Proclamation No. 1059, which declares the first week of October for the said observance.

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On October 12, 2024, the Life Underwriters Association of the Philippines (LUAP) and the Insurance Commission (IC) is set to host the biggest gathering of life insurance companies and the general public through its LIFEST: InsuRUNce 2024, a night run that will be held at Bridgetowne Destination Estate in Pasig City. 

Held in its second year, LUAP Insurance Festival or LIFEST is being held to commemorate the Life Insurance Consciousness Week, per Proclamation No. 1059, which declares the first week of October for the said observance. 

“We recognize the importance of the general public being able to be aware of the benefits of life insurance, which is the main reason why we have partnered with LUAP for this activity this year,” said Atty. Reynaldo A. Regalado, Insurance Commissioner. “We believe that LUAP, together with us at the Insurance Commission, have the leverage and influence to gather and unify life insurance companies in a significant activity such as this one.”

The LIFEST: InsuRUNce 2024 is a night run that includes three categories: pet run, kiddie run, and a regular fun run for running enthusiasts. Each category will be inclusive of a race shirt, race bib, and goodie bag. For the 3Km, 5Km, and 10Km run, additional glow sticks and neon socks will be provided. Pet and kiddie run will only cover 1Km. The run is open to the public via RaceYa: https://register.raceya.fit/event/lifest-2024

Awards and prizes will be provided for the 1Km Kiddie Run, 3Km, 5Km, and 10Km categories: Medals for top 3 male and female and a Top Senior runner for the 10Km category. For the 1Km Pet Run, the awards that will be provided will be: Best Dressed Award, Most Glamorous Dog, and Best Instagram Post. 

“As an association composed of life insurance companies in the country, we at LUAP have seen collaboration beyond company colors. LUAP Insurance Festival or LIFEST is a testament of our commitment to foster camaraderie among financial advisors no matter what their company colors are,” said Nonna Medina, 2024 LUAP National President. “For the second year, we want financial advisors to take a breather, have fun, and celebrate life.”

Registration to the fun run will end on Thursday, October 10, 2024.

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