{"id":9305,"date":"2024-05-20T15:03:06","date_gmt":"2024-05-20T07:03:06","guid":{"rendered":"http:\/\/zestmag.com\/online\/?p=9305"},"modified":"2024-05-20T15:04:40","modified_gmt":"2024-05-20T07:04:40","slug":"acetaminophen-reduces-sepsis-patients-risk-of-having-organ-injury","status":"publish","type":"post","link":"http:\/\/zestmag.com\/online\/acetaminophen-reduces-sepsis-patients-risk-of-having-organ-injury\/","title":{"rendered":"Acetaminophen reduces sepsis patients\u2019 risk of having organ injury"},"content":{"rendered":"\n

Intravenous acetaminophen reduced sepsis patients\u2019 risk of having organ injury or developing acute respiratory distress syndrome, a serious condition that allows fluid to leak into the lungs. <\/strong><\/p>\n\n\n\n

This is according to a study, “Phase 2b Randomized Trial of Acetaminophen for Prevention and Treatment of Organ Dysfunction in Critically Ill Sepsis Patients”, that appeared in JAMA<\/a><\/em>.<\/p>\n\n\n\n

As FYI: Sepsis is the body\u2019s uncontrolled and extreme response to an infection. In sepsis, red blood cells become injured and die at abnormally high rates, releasing so called \u201ccell-free hemoglobin\u201d into the blood. The body becomes overwhelmed and can\u2019t remove this excess hemoglobin which can lead to organ damage. <\/p><\/blockquote>\n\n\n\n

While the trial did not improve mortality rates in all patients with sepsis regardless of severity, the researchers found that acetaminophen gave the greatest benefit to the patients most at risk for organ damage. With the therapy, those patients needed less assisted ventilation and experienced a slight, though statistically insignificant, decrease in mortality.<\/p>\n\n\n\n

To test the therapeutic potential of acetaminophen more fully in a mid-stage clinical trial, researchers enrolled 447 adults with sepsis and respiratory or circulatory organ dysfunction at 40 US academic hospitals from October 2021 to April 2023. <\/p>\n\n\n\n

Patients were randomized to receive either acetaminophen or a placebo intravenously every six hours for five days. The researchers then followed the patients for 28 days to see how they fared. They also completed a special analysis using data only from the patients with levels of cell-free hemoglobin above a certain threshold. The team’s primary interest overall was the number of patients who were able to stay alive with no organ support, such as mechanical ventilation or kidney failure treatment.<\/p>\n\n\n\n

Scientists note that identifying high levels of cell-free hemoglobin as a biomarker that could be tested when patients are first admitted to the hospital would be a breakthrough, because it could help quickly determine which patients with sepsis might benefit from acetaminophen therapy.<\/p>\n\n\n\n

The researchers found that intravenous acetaminophen was safe for all the sepsis patients, with no difference in liver injury, low blood pressure, or other adverse events compared to the placebo group. Among secondary outcomes, they also found that organ injury was significantly lower in the acetaminophen group, as was the rate of acute respiratory distress syndrome onset within seven days of hospital admission.<\/p><\/blockquote>\n\n\n\n

When looking more closely at the patients with higher cell-free hemoglobin, the researchers found that just 8% of patients in the acetaminophen group needed assisted ventilation compared to 23% of patients in the placebo group. And after 28 days, 12% of patients in the acetaminophen group had died, compared to 21% in the placebo group, though this finding was not statistically significant.<\/p>\n\n\n\n

\u201cWhile the anticipated effects of acetaminophen therapy were not realized for all sepsis patients, this study shows that it still holds promise for the most critically ill\u201d said James Kiley. \u201cThough, more research is needed to uncover the mechanisms and validate these results.\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"

Intravenous acetaminophen was safe for all the sepsis patients, with no difference in liver injury, low blood pressure, or other adverse events compared to the placebo group. Among secondary outcomes, they also found that organ injury was significantly lower in the acetaminophen group, as was the rate of acute respiratory distress syndrome onset within seven days of hospital admission.<\/p>\n","protected":false},"author":18,"featured_media":9306,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4],"tags":[1785,842,1015],"class_list":["post-9305","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-newsmakers","tag-alternative-medicine","tag-future-of-medicine","tag-medicine"],"_links":{"self":[{"href":"http:\/\/zestmag.com\/online\/wp-json\/wp\/v2\/posts\/9305","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/zestmag.com\/online\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/zestmag.com\/online\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/zestmag.com\/online\/wp-json\/wp\/v2\/users\/18"}],"replies":[{"embeddable":true,"href":"http:\/\/zestmag.com\/online\/wp-json\/wp\/v2\/comments?post=9305"}],"version-history":[{"count":1,"href":"http:\/\/zestmag.com\/online\/wp-json\/wp\/v2\/posts\/9305\/revisions"}],"predecessor-version":[{"id":9307,"href":"http:\/\/zestmag.com\/online\/wp-json\/wp\/v2\/posts\/9305\/revisions\/9307"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/zestmag.com\/online\/wp-json\/wp\/v2\/media\/9306"}],"wp:attachment":[{"href":"http:\/\/zestmag.com\/online\/wp-json\/wp\/v2\/media?parent=9305"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/zestmag.com\/online\/wp-json\/wp\/v2\/categories?post=9305"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/zestmag.com\/online\/wp-json\/wp\/v2\/tags?post=9305"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}