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Popular prescription weight loss drugs linked to uncommon blinding condition

Patients prescribed semaglutide (as Ozempic or Wegovy) for diabetes or weight loss had a higher risk of having a potentially blinding eye condition called NAION than similar patients who had not been prescribed these drugs.

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A new study led by investigators from Mass Eye and Ear found that patients prescribed semaglutide (as Ozempic or Wegovy) for diabetes or weight loss had a higher risk of having a potentially blinding eye condition called NAION than similar patients who had not been prescribed these drugs.

Notably, the study found people with diabetes who had been prescribed semaglutide by their physician and then filled the prescription were more than four times more likely to be diagnosed with NAION. Those who were overweight or had obesity and prescribed this drug were more than seventimes more likely to get the diagnosis.

The study, which was led by Joseph Rizzo, MD, director of the Neuro-Ophthalmology Service at Mass Eye and Ear and the Simmons Lessell Professor of Ophthalmology at Harvard Medical School,  published July 3rd in JAMA Ophthalmology.

“The use of these drugs has exploded throughout industrialized countries and they have provided very significant benefits in many ways, but future discussions between a patient and their physician should include NAION as a potential risk,” said Rizzo, the study’s corresponding author. “It is important to appreciate, however, that the increased risk relates to a disorder that is relatively uncommon.” 

NAION is relatively rare, occurring up to 10 out of 100,000 people in the general population. NAION is the second-leading cause of optic nerve blindness (second only to glaucoma) and it is the most common cause of sudden optic nerve blindness. NAION is thought to be caused by reduced blood flow to the optic nerve head, with the consequence of permanent visual loss in one eye. According to Rizzo, the visual loss caused by NAION is painless and may progresses over many days before stabilizing, and there is relatively little potential for improvement. There are currently no effective treatments for NAION. 

The impetus for the study occurred in the late summer of 2023 when Rizzo, a resident (study co-author Seyedeh Maryam Zekavat, MD, PhD) and other Mass Eye and Ear neuro-ophthalmologists noticed a disturbing trend — three patients in their practice had been diagnosed with vision loss from this relatively uncommon optic nerve disease in just one week. The physicians observed all three were taking semaglutide.

This anecdotal recognition led the Mass Eye and Ear research team to run a backward-looking analysis of their patient population to see if they could identify a link between this disease and these drugs, which had been surging in popularity.

Semaglutide was developed to treat type 2 diabetes. The drug encourages weight loss, and its use has snowballed since its launch as Ozempic for diabetes in 2017. The drug was also approved for weight management, branded as Wegovy, and released in 2021.

The researchers analyzed the records of more than 17,000 Mass Eye and Ear patients treated over the six years since Ozempic was released and divided the patients in those who were diagnosed with either diabetes or overweight/ obesity. The researchers compared patients who had received prescriptions for semaglutide compared to those taking other diabetes or weight loss drugs. Then, they analyzed the rate of NAION diagnoses in the groups, which revealed the significant risk increases.

There are several limitations to the study. Mass Eye and Ear sees an unusually high number of people with rare eye diseases, the study population is majority white, and the number of NAION cases seen over the six-year study period is relatively small. With small case numbers, statistics can change quickly, Rizzo noted. The researchers also couldn’t determine if the patients actually took their medication or if they started and then stopped taking semaglutide at some point and how this might have impacted their risk.  

Importantly, the study does not prove causality, and the researchers don’t know why or how this association exists, and why there was a difference reported in diabetic and overweight groups.

“Our findings should be viewed as being significant but tentative, as future studies are needed to examine these questions in a much larger and more diverse population,” Rizzo said. “This is information we did not have before and it should be included in discussions between patients and their doctors, especially if patients have other known optic nerve problems like glaucoma or if there is preexisting significant visual loss from other causes.”

Authorship: In addition to Rizzo and Zekavat, other Mass General Brigham co-authors include Jimena Tatiana Hathaway, MD, MPH (MEE); Madhura P. Shah, BS (MEE); David B. Hathaway, MD (BWH); Drenushe Krasniqi, BA (MEE); John W. Gittinger Jr, MD (MEE); Dean Cestari, MD (MEE); Robert Mallery, MD (MEE); Bardia Abbasi, MD (MEE); Marc Bouffard, MD (MEE); Bart K. Chwalisz, MD (MEE) and Tais Estrela, MD (MEE).

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Watsons hosts PowHER Forum

This forum encouraged women to embrace their authentic selves while celebrating their strength, grit, and achievements.

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Watsons hosted its first-ever “Move with PowHER” Forum, an inspiring event dedicated to women’s wellness and empowerment. This forum encouraged women to embrace their authentic selves while celebrating their strength, grit, and achievements. It brought together women from diverse backgrounds—professionals, entrepreneurs, artists, community leaders, and more—to connect, share experiences, and uplift one another. Through engaging discussions on physical, emotional, and mental wellness, career growth, leadership, and advocacy, Watsons aimed to empower women to thrive in every aspect of their lives.

A Platform for Authentic Conversation and Empowerment

The event opened with a keynote speech by Lynn Pinugu, co-founder of She Talks Asia, an advocacy platform dedicated to sparking meaningful conversations about women’s strength, mental health, and gender equality. Drawing from her personal journey as a mother, wife, and advocate, Lynn shared how embracing authenticity has shaped her life and inspired her to drive change. She highlighted how She Talks Asia helps women redefine empowerment by breaking societal barriers and embracing their unique identities.

Lynn’s message resonated deeply with Watsons’ brand promise of “Look Good, Do Good, Feel Great,” which champions the uniqueness of every woman and celebrates both inner and outer beauty. She highlighted how She Talks Asia aligns with this vision by encouraging women to embrace their individuality, support one another, and actively contribute to their communities. Through initiatives such as scholarship programs, employee volunteerism, and sustainability efforts, Watsons inspires women to make a positive impact on society. Watsons aims to empower women to “Move with PowHER,” using their voices and talents to drive meaningful change, uplift one another, and confidently pursue their passions and achievements.

The forum featured insightful panel discussions that highlighted key areas where women are making a difference:

Physical & Mental Wellness:

Hazel Calawod, a sports occupational therapist, mental health professional, and coach of two-time gold Olympian Carlos Yulo, emphasized the importance of building physical and mental resilience. Drawing from her experience coaching elite athletes, she highlighted how mental toughness and physical strength are essential not only for peak performance in sports but also for navigating everyday challenges.

Women in Sports:

Nicole Dela Cruz, CEO of Women’s Run PH and an advocate for women in sports, discussed the significance of representation and resilience. She shared her journey of overcoming challenges in a male-dominated field, underscoring the vital role of mentorship and collaboration in empowering female athletes to pursue their passions.

Balancing Family & Work Life:

Sharon Decapia, SAVP of Watsons’ Marketing, PR & Sustainability, offered insights on balancing her roles as a corporate executive and mother. She emphasized that true empowerment involves embracing both family and career with purpose and confidence. Sharon provided practical advice on achieving personal and professional goals while prioritizing self-care and wellness, encouraging women to nurture themselves as they pursue their ambitions.

Women in Advocacy:

Lynn Pinugu returned to discuss the role of advocacy in driving social change. She emphasized how authentic conversations on mental health, gender equality, and self-empowerment break societal barriers, inspiring women to embrace their unique strengths and lead with purpose.

A key theme of the “Move with PowHER” forum was the importance of building supportive communities where women uplift one another. By nurturing these connections, Watsons continues to serve as a trusted partner, providing resources, products, and platforms that help women excel in all aspects of life.

The event redefined traditional notions of leadership, presenting it as a form of advocacy—whether for oneself, for other women, or for broader social issues. Attendees were inspired by stories of women leaders who are effecting meaningful change and discovered how they can also lead with purpose and passion. Through the “Move with PowHER” initiative, Watsons encouraged women to see leadership as a powerful opportunity to make a difference in their communities and beyond.

The forum also provided a vibrant atmosphere with interactive activities. Guests participated in a floral workshop where they created their own arrangements, reflecting the themes of growth and self-expression. Brand segments featured PH Care, Gynepro, Jeunesse, and partners like Modess, Charmee, Cleane, and Sisters, celebrating products that support women’s health and wellness.

“Move with PowHER” embodied Watsons’ brand promise, championing every woman’s right to look good, do good, and feel great. By celebrating individuality, Watsons inspires women to embrace their unique beauty and confidence. Through initiatives like scholarship programs, volunteerism, and sustainability efforts, Watsons encourages women to give back to their communities. By nurturing their success and well-being, Watsons fosters vibrant, empowered communities where women can thrive.

Visit your nearest Watsons store or shop through the Watsons App, available for download on the App Store and Google Play, to discover your favorite health, wellness, and beauty products.

As part of Watsons’ commitment to supporting women, Watsons offers a wide range of products and services designed to enhance their health, wellness, and beauty journeys. From skincare and cosmetics to vitamins and personal care essentials, Watsons provides everything women need to look good, do good, and feel great. For added convenience, customers can shop their favorite products through the Watsons App, available for download on the App Store and Google Play, or visit their nearest Watsons store.

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Not in the mood for sex after menopause?

Many women report a decline in sexual function, including desire, when transitioning through menopause. Such problems can contribute to poor self-image and negatively affect physical and emotional well-being.

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Many women report a decline in sexual function, including desire, when transitioning through menopause. Such problems can contribute to poor self-image and negatively affect physical and emotional well-being. A new study suggests that cognitive behavioral therapy may be a safe and effective treatment for mitigating sexual concerns during this period.  

Partially due to declining estrogen levels, 68% to 87% of peri- and postmenopausal women express sexual concerns. Despite such high prevalence and negative impacts, treatment options–particularly nonpharmacological ones–are quite limited. In response, researchers initiated a small study to evaluate the efficacy of a four-session individual cognitive behavioral therapy protocol for improving sexual functioning (eg, desire, arousal, pain, satisfaction). Secondary objectives included assessing body image, relationship satisfaction, menopause symptoms (such as hot flashes), depression, and anxiety during peri- and postmenopause.

The researchers found that participants in this study experienced a significant improvement in multiple areas of sexual functioning, body image and couple satisfaction, as well as a significant decrease in menopause symptoms, depression, and anxiety, and self-reported overall health. In addition, 100% of participants indicated they were very satisfied with the treatment and that it helped them cope with their symptoms more effectively.

“To our knowledge, this is the first study that has examined the efficacy of a cognitive behavioral therapy protocol specifically aimed to improve sexual concerns experienced during peri- and postmenopause,” says Dr. Sheryl Green, lead study author from McMaster University in Ontario, Canada. “Results suggest that this type of therapy leads to significant improvements across several important sexual concern domains, and we hope this study will provide the basis for larger randomized clinical trials in the future.”

“This study is important to women experiencing sexual health related issues and provides their healthcare professionals with another nonpharmacologic treatment option to discuss with their patients,” says Dr. Stephanie Faubion, medical director for The Menopause Society.

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LIFEST: InsuRUNce 2024 slated on Oct. 12

Held in its second year, LUAP Insurance Festival or LIFEST is being held to commemorate the Life Insurance Consciousness Week, per Proclamation No. 1059, which declares the first week of October for the said observance.

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On October 12, 2024, the Life Underwriters Association of the Philippines (LUAP) and the Insurance Commission (IC) is set to host the biggest gathering of life insurance companies and the general public through its LIFEST: InsuRUNce 2024, a night run that will be held at Bridgetowne Destination Estate in Pasig City. 

Held in its second year, LUAP Insurance Festival or LIFEST is being held to commemorate the Life Insurance Consciousness Week, per Proclamation No. 1059, which declares the first week of October for the said observance. 

“We recognize the importance of the general public being able to be aware of the benefits of life insurance, which is the main reason why we have partnered with LUAP for this activity this year,” said Atty. Reynaldo A. Regalado, Insurance Commissioner. “We believe that LUAP, together with us at the Insurance Commission, have the leverage and influence to gather and unify life insurance companies in a significant activity such as this one.”

The LIFEST: InsuRUNce 2024 is a night run that includes three categories: pet run, kiddie run, and a regular fun run for running enthusiasts. Each category will be inclusive of a race shirt, race bib, and goodie bag. For the 3Km, 5Km, and 10Km run, additional glow sticks and neon socks will be provided. Pet and kiddie run will only cover 1Km. The run is open to the public via RaceYa: https://register.raceya.fit/event/lifest-2024

Awards and prizes will be provided for the 1Km Kiddie Run, 3Km, 5Km, and 10Km categories: Medals for top 3 male and female and a Top Senior runner for the 10Km category. For the 1Km Pet Run, the awards that will be provided will be: Best Dressed Award, Most Glamorous Dog, and Best Instagram Post. 

“As an association composed of life insurance companies in the country, we at LUAP have seen collaboration beyond company colors. LUAP Insurance Festival or LIFEST is a testament of our commitment to foster camaraderie among financial advisors no matter what their company colors are,” said Nonna Medina, 2024 LUAP National President. “For the second year, we want financial advisors to take a breather, have fun, and celebrate life.”

Registration to the fun run will end on Thursday, October 10, 2024.

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