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New therapy targets breast cancer metastases in brain

A new combination therapy targeting breast cancer tumors in the brain dramatically decreased tumor size and increased survival in a study with mice, reports a new Northwestern Medicine study. An estimated 75% of mice that had brain metastases from breast cancer were cured and cancer-free after the therapy.

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When breast cancer spreads to the brain, the prognosis is grim. Patients only have about six months to live.

Women with HER2-positive breast cancer tend to develop brain metastases in up to 55% of cases. Chemotherapy drugs targeting breast cancer cells in the brain aren’t effective, because they can’t cross the blood-brain-barrier.

But a new combination therapy targeting breast cancer tumors in the brain dramatically decreased tumor size and increased survival in a study with mice, reports a new Northwestern Medicine study. An estimated 75% of mice that had brain metastases from breast cancer were cured and cancer-free after the therapy.

“The new combination therapy we identified can cross the blood-brain barrier,” said lead study author Dr. Maciej Lesniak, Northwestern Medicine chair of neurological surgery and professor of neurosurgery at Northwestern University Feinberg School of Medicine. “The therapy also targets brain metastases and significantly improves survival.”

The paper is published Science Translational Medicine.

The two drugs are tubulin inhibitor, vinorelbine, approved by the U.S. Food and Drug Administration (FDA) and available in clinics, and bromodomain inhibitor, I-BET-762, FDA approved for clinical trials. The bromodomain inhibitor increased βIII-tubulin, a protein found in cancer cells that metastasize to the brain. Overexpression of βIII-tubulin sensitized cancer cells to be killed by vinorelbine.

“The findings of our work set the stage for a clinical trial, whereby patients with breast cancer brain metastases can be treated with the combination of these two drugs,” Lesniak said. “This will offer patients with breast cancer brain metastases, who have been systematically excluded from clinical trials, the chance to benefit from a new therapeutic regimen that has been proven to be strongly effective in experimental settings.”

Breast cancer spreads to other organs like brain, lung and bone. The metastasis of breast cancer to the brain is a terminal disease and the deadliest complication.

There is a lack of targeted therapies for breast cancer brain metastases, said first study author Deepak Kanojia, research associate in neurological surgery at Feinberg.

“Patients with brain metastases are often excluded from clinical trials due to their poor outcomes and dismal survival,” Kanojia said. “Regular systemic therapies, like Herceptin, do not cross the blood-brain-barrier efficiently, and offer no benefit in brain metastases,” he said.

How the study worked

Scientists developed a mouse model that can grow multiple brain metastases to simulate what happens in human patients. They injected tumor cells in the intracarotid artery, resulting in the formation of multiple brain tumors. After the tumors grew, scientists treated the mice with the combination therapy. Final results revealed that 75% of the mice that were treated with the combination were cured and cancer-free.

Other Northwestern authors include co-first author Wojciech Panek, Alex Cordero, Jawad Fares, Solomiia Savchuk, Krishan Kumar, Ting Xiao, Katarzyna Pituch, Jason Miska, Peng Zhang, Kwok-Ling Kam, Craig Horbinski, Irina Balyasnikova and Atique Ahmed.

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Men with sensory loss are more likely to be obese

The association between physical activity and obesity was higher in men with hearing loss, who were 2.319 times more likely to be obese than women who reported difficulty hearing. Obesity in those with sight loss was 1.556 times higher in inactive men than women.

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Photo by @blocks from Unsplash.com

Men who suffer sensory loss, particularly hearing loss, are more likely to be physically inactive and obese than women, according to a new study published in the European Journal of Public Health.

Researchers analysed data from more than 23,000 Spanish adults, and examined associations with physical inactivity and obesity in people with vision and hearing loss, and explored differences between men and women.

Results suggest inactive people with hearing loss were 1.78 times more likely to be obese compared to those who did not have any hearing loss. In people who had difficulty seeing, the odds ratio is slightly smaller, with a likelihood of obesity being 1.375 times higher than those who did not report vision loss.

The association between physical activity and obesity was higher in men with hearing loss, who were 2.319 times more likely to be obese than women who reported difficulty hearing. Obesity in those with sight loss was 1.556 times higher in inactive men than women.

Those with combined seeing and hearing difficulties had the highest prevalence of physical inactivity (44.8%) and obesity (26.1%). Analysis showed a significant association between physical inactivity and obesity in men with vision or hearing loss, but not in women.

Around 62% of adults in Spain are overweight, with 26% reporting as obese. In the UK, the figures are broadly similar at around 64% and 28% respectively, suggesting strong similarities between the countries.

A total of 11.04% of the people surveyed self-reported vision loss, 6.96% reported hearing loss, and 3.93% reported suffering both vision and hearing loss.

Lead author Professor Shahina Pardhan, Director of the Vision and Eye Research Institute at Anglia Ruskin University, said: “It is clear from our study that there are significant differences between genders.

“Although women were overall less physically active than men, we found an association between physical inactivity and obesity in men, but not in women. This indicates that, especially in people with vision and hearing losses, exercise and being active has a very important role in preventing obesity for men.

“Adults, especially those with sensory losses, should be encouraged to be as physically active as possible but there are obviously challenges, strongly suggesting that intervention and encouragement would play a very important role.

“An effective strategy to increase the levels of physical activity in this population group would be through targeted intervention programmes based on health awareness on the importance of physical activity.”

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Dad tips we take for granted but go a long way

With all the pressure that comes with responsibilities, dads also need to look after their own wellbeing too.

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Photo by @picsea from Unsplash.com

There is no one-size-fits all way to being a father, but most working dads want to do the best to support their loved ones. With all the pressure that comes with these responsibilities, dads also need to look after their own wellbeing too. 

Donato Avellana is the Health and Wellbeing Lead for the Vibe Team at Canva Philippines, and as a father himself, he acknowledges the importance of work-life balance. He has helped build programs at Canva that empower employees to have a healthy work-life balance, with holistic programs for all domains of wellness. Taking his learnings from this, he shares some helpful and practical tips to help dads to develop healthy habits that can boost their happiness at work and at home. 

1. Rest and recover well

Rest and relaxation is crucial to improve our overall health. Try your best to get at least 7 hours of sleep, go to bed an hour before you go to sleep, and stay away from your TV or mobile phone, as several studies show that the blue light from screens can disrupt sleep. Sleep is often a neglected component of overall well-being, but this is where the body repairs itself to get ready for another day. Remember that you deserve to rest.

2. Start your day with a cold shower 

Showering can also offer more benefits than many realise.  By using water that is a little cold, you can improve blood circulation, with the lower temperature causing blood to run to the skin’s surface. Good blood circulation plays an important role in our health for proper nutrient distribution throughout our body.

This is also a good time for dads to have their ‘me’ time. Breathing exercises are a great way to start the day, by offering the opportunity to regroup and reflect. 

3. Move more, make it a habit

The health benefits of movement have been scientifically proven time and time again. Your body is connected to your brain and your movement habits can positively impact how you think and feel. Inactivity can make you feel sluggish and tired, making it hard to find motivation and deliver on responsibilities.

Add regular walks, stand often, or follow stretching routines that you can commit to during the day. Taking time for a short 10-15-minute walk is a great way to have a mental and physical break.

4. Eat smart: practice a mindful eating habit. 

We have been educated about what healthy eating is since we were kids. Eating intuitively on a regular schedule is very important. Eating with no structure creates mindless eating that can lead to poor nutrition choices. Think of nourishing your body with healthy fuel for efficient performance instead of just eating. Eat a variety of whole foods, have fruits and vegetables, and hydrate smartly.

5. It’s okay to ask for help

This shortlist might not be easy for everyone, so I encourage dads to seek help when they need it. You might want to start at home with your spouse, ask for help from co-workers, peers, fellow fathers, professionals such as your doctor.

Showing appreciation to your father

If you’re still looking for heart-felt gift ideas for your dad, you can browse through Canva for free design ideas and inspiration. 

Make your dad, grandfather or any other special figure feel loved and appreciated by designing personalized cards. A wide variety of photos, customizable templates, and full-color professional layouts are available. You can also find Filipino templates by changing the language settings to Tagalog and searching for the word ‘tatay’.

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Sun Life Philippines holds ‘Tiny Habits’ workshop

The interactive event carried a fitness theme and was conducted by certified Tiny Habits Coaches TJ Agulto and Claire Limof AHA! Behavorial Design.They shared tips on creating tiny habits in a continuous period of two weeks and also emphasized the importance of celebrating small wins.

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Members of Sun Life Philippines’ Bright Habit Starters community were recently treated to an exclusive workshop on Tiny Habits, the breakthrough method for building habits by world-renowned Behavior Scientist Dr. BJ Fogg.

The interactive event carried a fitness theme and was conducted by certified Tiny Habits Coaches TJ Agulto and Claire Limof AHA! Behavorial Design.They shared tips on creating tiny habits in a continuous period of two weeks and also emphasized the importance of celebrating small wins.

The event was followed by one-on-one coaching sessions to help the participants commit to their habits. This was supervised through the Bright Habits Chatbot, which prompted them to perform daily check-ins for two weeks. This led to the participants achieving 93% success rate in practicing their Bright Tiny Habits.

Following the launch, a second batch of participants is now undergoing the same program, this time with the goal of creating habits to improve their relationships.

The Tiny Habits workshop is just one of the many perks enjoyed by the Bright Habit Starter community. Members are also provided with helpful tips, exclusive promos, and other activities designed to create a sustained behavior change in the present so they can reach their goals in the future. Launched just last March as part of Sun Life’s Ito Ang Araw Mo campaign, the community now has over 3,000 members.

Those interested to be a part of the Bright Habit Starters Community simply have to join via Facebook https://www.facebook.com/groups/itoangarawmo.

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