NewsMakers
Coffee doesn’t raise your risk for heart rhythm problems
Each additional daily cup of coffee consumed among several hundred thousand individuals was associated with a 3 percent lower risk of any arrhythmia occurring, including atrial fibrillation, premature ventricular contractions, or other common heart conditions.

In the largest study of its kind, an investigation by UC San Francisco has found no evidence that moderate coffee consumption can cause cardiac arrhythmia.
In fact, each additional daily cup of coffee consumed among several hundred thousand individuals was associated with a 3 percent lower risk of any arrhythmia occurring, including atrial fibrillation, premature ventricular contractions, or other common heart conditions, the researchers report. The study included a four-year follow up.
The paper is published in JAMA Internal Medicine.
“Coffee is the primary source of caffeine for most people, and it has a reputation for causing or exacerbating arrhythmias,” said senior and corresponding author Gregory Marcus, MD, professor of medicine in the Division of Cardiology at UCSF.
“But we found no evidence that caffeine consumption leads to a greater risk of arrhythmias,” said Marcus, who specializes in the treatment of arrhythmias. “Our population-based study provides reassurance that common prohibitions against caffeine to reduce arrhythmia risk are likely unwarranted.”
While some professional societies suggest avoiding caffeinated products to lower the risk for arrhythmia, this connection has not been consistently demonstrated – indeed, coffee consumption may have anti-inflammatory benefits and is associated with reduced risks of some illnesses including cancer, diabetes, and Parkinson disease.
In the new study, UCSF scientists explored whether habitual coffee intake was associated with a risk of arrhythmia, and whether genetic variants that affect caffeine metabolism could modify that association. Their investigation was conducted via the community-based UK Biobank, a prospective study of participants in England’s National Health Services.
Some 386,258 coffee drinkers took part in the coffee research, with an average mean age of 56 years; slightly more than half were female. It was an unprecedented sample size for this type of inquiry.
In addition to a conventional analysis examining self-reported coffee consumption as a predictor of future arrhythmias, the investigators employed a technique called “Mendelian Randomization,” leveraging genetic data to infer causal relationships. As those with the genetic variants associated with faster caffeine metabolism drank more coffee, this analysis provided a method to test the caffeine-arrhythmia relationship in a way that did not rely on participant self-report and should have been immune to much of the confounding inherent to most observational studies.
With a mean four-year follow up, data were adjusted for demographic characteristics, health and lifestyle habits.
Ultimately, approximately 4 percent of the sample developed an arrhythmia. No evidence of a heightened risk of arrhythmias was observed among those genetically predisposed to metabolize caffeine differently. The researchers said that higher amounts of coffee were actually associated with a 3 percent reduced risk of developing an arrhythmia.
The authors noted limitations including the self-reporting nature of the study, and that detailed information on the type of coffee – such as espresso or not – was unavailable.
“Only a randomized clinical trial can definitively demonstrate clear effects of coffee or caffeine consumption,” said Marcus. “But our study found no evidence that consuming caffeinated beverages increased the risk of arrhythmia. Coffee’s antioxidant and anti-inflammatory properties may play a role, and some properties of caffeine could be protective against some arrhythmias.”
Co-authors are Eun-jeong Kim, MD; Thomas J. Hoffmann, PhD; Gregory Nah, MA; Eric Vittinghoff, PhD; and Francesca Delling, MD, all of UCSF.
NewsMakers
Research suggests drinking coffee may reduce the risk of frailty
Habitual coffee consumption of 4-6 cups and over* (with one cup measuring at 125ml) per day is associated with a reduced risk of frailty.

A new study published in the European Journal of Nutrition has suggested that habitual coffee consumption of 4-6 cups and over* (with one cup measuring at 125ml) per day is associated with a reduced risk of frailty.
The study, funded by the Institute for Scientific Information on Coffee (ISIC) is the first to analyze the relationship between coffee consumption and the underlying components of frailty.
Coffee consumption has previously been linked to reducing the risk of some of the natural symptoms of ageing, such as improving cognitive function2 and mitigating against inflammatory related diseases. This latest research adds to the growing knowledge base within this area, exploring the benefits of regular coffee consumption over an extended period of time.
For this study, researchers conducted a detailed analysis over a long seven-year follow-up period, surveying 1,161 adults aged 55+ years through the Longitudinal Aging Study Amsterdam (LASA).
The relationship between coffee consumption and the presence and incidence of frailty was investigated. Frailty status was evaluated using Fried’s five-component frailty phenotype4,which is defined by the presence of three or more of the following symptoms: weight loss, weakness, exhaustion, slow gait (walking) speed, and low physical activity.
The results of this study indicate that higher habitual coffee consumption is associated with lower overall odds of frailty. These findings can be considered alongside the European Food Safety Authority’s (EFSA) scientific opinion that up to 400mg of caffeine (3-5 cups of coffee) per day is a moderate and safe amount5.
The researchers explain that coffee’s effect on reducing frailty can partly be attributed to the role of antioxidants in coffee, which may help to reduce inflammation, sarcopenia (muscle loss), and prevention of muscle damage. Coffee may also help to improve regulating insulin sensitivity and glucose uptake in older people.
The study’s lead author, Margreet R. Olthof, Associate Professor at the Amsterdam Public Health Research Institute, Vrije Universiteit Amsterdam, commented: “Drinking coffee is a key part of many people’s daily routine, and as people age they are constantly looking for ways to maintain their health. Our findings highlight the possible beneficial association between daily coffee consumption and reduced risk of frailty in later life in the older population. Coffee consumption may thus enhance healthy aging, but it is important we also explore further dietary interventions, to ensure older adults can continue to live fulfilling lives.”
* Moderate coffee consumption can be defined as 3–5 cups per day, based on the European Food Safety Authority’s review of caffeine safety.
NewsMakers
Landers opens first Cavite store in Vermosa
Landers Superstore, the fastest growing membership store in the country, proudly marks another milestone with the grand opening of Landers Vermosa – its first-ever store in the province and its 15th store nationwide.

Premium membership shopping has finally arrived in Cavite.
Landers Superstore, the fastest growing membership store in the country, proudly marks another milestone with the grand opening of Landers Vermosa – its first-ever store in the province and its 15th store nationwide.
Conveniently located inside Ayala Vermosa’s sprawling estate and lifestyle hub in Imus, Cavite, the newest Landers store offers a fresh and elevated way of shopping for Caviteños, complete with massive savings, world-class finds, and exclusive membership perks, all under one roof. It is also the largest Landers store to date at 12,900 sqm, promising a bigger and better experience for every member who walks through its doors.
Welcoming Landers in Cavite
Landers Vermosa opened with an exciting grand launch that brought together members of the media, content creators, and special guests for a first look at the newest and biggest Landers Superstore. The attendees were in high spirits as they explored the spacious store and enjoyed exclusive product samplings and guided tours.
During the event, Landers Deputy Chief Executive Officer Bill Cummings delivered heartfelt opening remarks, expressing his excitement for the new store and his appreciation for the warm welcome from the Cavite community, noting that over 60,000 members had already signed up prior to opening day – a clear sign of the anticipation surrounding the launch.
The celebration also highlighted the strong collaboration between Landers Superstore and Ayala Land, along with the support of the city government of Imus, led by Mayor Alex Advincula. The event underscored Landers’ commitment to bringing world-class shopping experiences to more Filipino families, starting with the vibrant and growing community in Cavite.
What to expect at Landers Vermosa
At Landers Vermosa, members can look forward to filling their carts with high-quality local and imported products—from daily essentials to unique international finds. Beyond shopping, the store offers a host of exclusive perks that make every visit more rewarding. Members can enjoy free haircuts or blow-dry services at Federal Barbers, low-priced medicine and wellness products at Capital Care Pharmacy, up to P10 off per liter at Landers-Caltex gas stations, and up to 50% off on Solane LPG refills.
Members of Landers Vermosa will gain access to all of Landers Superstore’s massive sale events like Super Crazy Sale and 50% Off Produce Sale, which offer unbeatable savings on a wide range of products. To complete the experience, members can enjoy regular in-store activities every month and free product samplings that are perfect for the whole family.
Sign up for Landers membership
Be among the first to explore this exciting new shopping destination and enjoy all the perks that come with being a Landers member.
If you’re not yet a member, now’s the perfect time to sign up! Memberships are currently on sale at 50% off—just P350 for a full year of exclusive savings and benefits. Promo runs until May 31.
Looking for even more value? Apply for the Landers Cashback Everywhere Credit Card and get up to 5% cashback on all Landers purchases, plus earn rewards wherever you shop.
Landers Vermosa is here with more perks, more savings, and more reasons to love shopping in the South. See you in-store.
NewsMakers
Cannabidiol therapy could reduce symptoms in autistic children and teenagers
The use of cannabidiol (CBD) cannabis extract can lead to meaningful benefits and improve the behaviour of children and adolescents with autism spectrum disorder.

New research presented at the 2025 European Congress of Psychiatry reveals that the use of cannabidiol (CBD) cannabis extract can lead to meaningful benefits and improve the behaviour of children and adolescents with autism spectrum disorder (ASD). ASD affects approximately 1 in 100 children around the world and symptoms can include difficulty interpreting language, difficulty expressing emotions, and repetitive behaviour and routines.1,2
The meta-analysis included randomised, placebo-controlled trials on the efficacy or safety of CBD cannabis extracts in children and adolescents with ASD. Three studies were used in total with 276 participants with a mean age of 10.5, ranging in age from 5 to 21. The dosage of CBD cannabis extract started at 1 mg/kg per day and was titrated up to 10 mg/kg.
Key findings from the study include:
- CBD cannabis extract use shows moderate improvements in social responsiveness and small yet notable reductions in disruptive behaviours.
- CBD cannabis extract significantly enhanced social responsiveness and reduced disruptive behaviour.
- The use of CBD cannabis extract has a favourable safety profile as it did not increase adverse events compared to placebo
- There were no significant differences between adverse events in CBD cannabis extract versus placebo
Lara Cappelletti Beneti Branco, Lead Investigator, São Camilo University Center, University of São Paulo, said: “The global population prevalence of ASD diagnosis amongst children and adolescents is growing, but many treatment pathways are not effective. It is promising to see the effect of CBD cannabis extract on the study participants. However, there still needs to be considerable focus on further research with larger trials to clarify its efficacy and safety in managing ASD.”
Professor Geert Dom, EPA President, said: “ASD can be extremely frustrating for all involved; parents of children and adolescents with the disorder, the treating clinicians and of course the children and adolescents themselves. A large part of this frustration is down to finding a viable treatment option that works to reduce symptoms. It is with delight that we see the results of this meta-analysis and we hope to see further research into this so we can move towards a solution to the unmet need within this community”.
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